A5087204880- Advanced Condensed Matter Physics
- Enzyme Production and Characterization
- Advanced Cellulose Research Studies
- Magnetic and transport properties of perovskites and related materials
- X-ray Diffraction in Crystallography
- Antioxidant Activity and Oxidative Stress
- Polysaccharides and Plant Cell Walls
- Studies on Chitinases and Chitosanases
- Protein Hydrolysis and Bioactive Peptides
- Crystallization and Solubility Studies
- Meat and Animal Product Quality
- Gastrointestinal motility and disorders
- Advanced Sensor and Energy Harvesting Materials
- Cancer-related gene regulation
- Perovskite Materials and Applications
- Electronic and Structural Properties of Oxides
- Microbial Metabolites in Food Biotechnology
- Polysaccharides Composition and Applications
- Transition Metal Oxide Nanomaterials
- Biofuel production and bioconversion
- Algal biology and biofuel production
- Proteins in Food Systems
- Organic and Molecular Conductors Research
- Microscopic Colitis
- Advanced Glycation End Products research
Ludong University
2018-2025
South China University of Technology
2016-2025
China National Petroleum Corporation (China)
2025
State Key Laboratory of Luminescent Materials and Devices
2024-2025
Luye Pharma (China)
2025
Northwestern University
2020-2024
Lurie Children's Hospital
2020-2024
Beijing University of Chemical Technology
2010-2024
Union Hospital
2022-2024
Huazhong University of Science and Technology
2022-2024
Abstract The over-expressed colonic brain-derived neurotrophic factor (BDNF) has been reported to be associated with abdominal pain in patients irritable bowel syndrome (IBS). However, the neuropathological mechanism is unclear. We here investigated involvement of enteroglial cells (EGCs) and enteric nerves IBS-like visceral hypersensitivity. showed that glial fibrillary acidic protein (GFAP), tyrosine receptor kinase B (TrkB) substance P (SP) were significantly increased mucosa IBS...
Abstract Background Eukaryotic protein translation elongation factor 1α2 ( EEF1A2 ) is an oncogene that promotes the progression of breast and pancreatic cancer. In this study, we aimed to elucidate oncogenic function in metastasis lung adenocarcinoma (LUAD). Methods Immunohistochemistry western blot were used study expression levels LUAD tissues cells, respectively. The role investigated vitro vivo. We identified potential EEF1A2-binding proteins by liquid chromatography-electrospray mass...
Bioactive peptides (BAPs) represent a unique class of known for their extensive physiological functions and role in enhancing human health. In recent decades, owing to notable biological attributes such as antioxidant, antihypertensive, antidiabetic, anti-inflammatory activities, BAPs have received considerable attention. Simulated gastrointestinal digestion (SGD) is technique designed mimic conditions by adjusting factors digestive enzymes concentrations, pH levels, duration, salt content....
This paper describes preparation of 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) mediated oxidized cellulose nanofibers (TOCNs) from corn husk.The process adopted for this work included alkaline treatment, TEMPO/NaBr/NaClO-mediated oxidation, and homogenization.The morphological investigation TOCNs was performed using atomic force microscopy (AFM) transmission electron (TEM).The chemical composition structure the material obtained after each stage treatments characterized through Fourier...
This study examined the prospective and reciprocal relationships among perceived parental control, self-criticism, nonsuicidal self-injury (NSSI). We also mediating effect of self-criticism in relationship between control NSSI. aimed to find out whether acted as risk factors for NSSI, or consequences both. A group 3,600 Chinese adolescents (mean age = 14.63 years, 56.6% female) completed questionnaires, with measures assessing control. cross-lag model was used test variables at 3 time points...
Abstract With the rapid development of wearable and portable electronic devices, it is increasingly important to develop conductive paper-like films (CPFs) with characteristics light, thin self-supporting. In this paper, nanofibrillated cellulose (NFC) was used as reinforcing phase film-forming combine graphene oxide (GO). Then graphene-based CPFs were prepared by directly reducing GO/NFC composite film without any additional adhesives, which effectively avoided difficulties dispersion...
This investigation sought to identify antioxidative peptides derived from Meretrix meretrix L. (MML) throughout simulated gastrointestinal digestion (SGD) via in vitro and silico strategies. The study demonstrated that hydrolysates MML captured at various SGD phases showcased robust activity. These also displayed a protective role against hydrogen peroxide-induced stress Raw 264.7 cells. Notably, sourced the intestinal phase of (MMLHs-I) markedly inhibited reduction cell viability, limited...
Cytotoxic enzymes often exist as zymogens containing prodomains to keep them in an inactive state. Protein-glutaminase (PG), which can enhance various functional characteristics of food proteins, is enzyme pro-PG and mature-PG (mPG). However, poor activity stability limit its application while tedious purification activation steps high-throughput engineering. Here, based on structural analysis, we replaced the linker sequence between mPG with HRV3C protease recognition then coexpressed it
Abstract Colonic brain-derived neurotrophic factor (BDNF) plays an essential role in pathogenesis of abdominal pain diarrhea-predominant irritable bowel syndrome (IBS-D), but regulation on its expression remains unclear. We investigated the fecal supernatants (FSN) from IBS-D patients regulating BDNF colonic epithelial cells human and mice. Using Caco-2 cells, we found that FSN significantly increased mRNA protein levels compared to control FSN, which were remarkably suppressed by serine...
The current study was designed to elucidate the cytoprotective effects and possible mechanisms of torulene torularhodin on hydrogen peroxide (H2O2)-induced oxidative stress damage in human prostate stromal cells (WPMY-1). After treated with H2O2, a notable decrease appeared cell viability, yet attenuated when were pretreated (0.5-10 μM) as evaluated by WST-1 assay. Pretreatment these two carotenoids significantly H2O2-induced apoptosis WPMY-1 through inhibition intracellular reactive oxygen...
With regard to important changes in chemical composition, germination can be considered a valuable processing technique for modifying nutrient components of legume seeds. In this study, the major composition peanut seeds were evaluated during short-term germination. The contents water, minerals, aspartic acid, methionine, proline, folic thiamine and total phenolics increased dramatically cotyledons sprouts after germination, while fat, riboflavin ascorbic acid decreased markedly. content...
The construction of an efficient multienzyme catalyst for dismantling recalcitrant polymers into high-value-added chemicals is appealing in sustainable biomanufacturing. Colocalization cascade enzymes has been broadly adopted by natural and synthetic systems chemical synthesis, while there rare research on the decomposition polymeric substrates. In this study, we constructed E. coli surface-assembly (ESA) system to colocalize a chitinosome composed two chitin hydrolases, BpChiA BlNagZ, via...
Clinical evidence indicates a connection between gut injuries, infections, inflammation, and an increased susceptibility to systemic inflammation. Nevertheless, the animal models designed replicate this progression are inadequate, fundamental mechanisms still largely unknown. This research explores relationship injuries inflammation using Dextran Sulfate Sodium (DSS)-induced colonic mucosal injury mouse model. Continuous treatment of adult mice with 4% DSS drinking water yielded remarkable...