A5102810524- Antiplatelet Therapy and Cardiovascular Diseases
- Coronary Interventions and Diagnostics
- Immune cells in cancer
- Atrial Fibrillation Management and Outcomes
- Antibiotics Pharmacokinetics and Efficacy
- Nanoplatforms for cancer theranostics
- Acute Myocardial Infarction Research
- Cancer Cells and Metastasis
- Cardiac electrophysiology and arrhythmias
- Cancer, Stress, Anesthesia, and Immune Response
- Vitamin D Research Studies
- Metabolism and Genetic Disorders
- Genetics and Neurodevelopmental Disorders
- Hippo pathway signaling and YAP/TAZ
- Histone Deacetylase Inhibitors Research
- Hemophilia Treatment and Research
- Cardiac Imaging and Diagnostics
- Prenatal Screening and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Immune Response and Inflammation
- Epigenetics and DNA Methylation
- Advanced biosensing and bioanalysis techniques
- Venous Thromboembolism Diagnosis and Management
- Asthma and respiratory diseases
- Viral Infections and Immunology Research
Lanzhou University
2021-2024
First Hospital of Lanzhou University
2021-2024
Hebei Medical University
2024
Second Hospital of Hebei Medical University
2024
Peking University
2013-2024
Chinese PLA General Hospital
2014-2024
Beijing Jishuitan Hospital
2021-2024
Capital Medical University
2024
Inner Mongolia University of Science and Technology
2023
Harbin Medical University
2019-2021
The yes-associated protein (YAP) transcription co-activator has been reported either as an oncogene candidate or a tumor suppressor. Liver tissue chips revealed that about 51.4% human hepatocellular carcinoma (HCC) samples express YAP and 32.9% HCC phosphorylated YAP. In this study, we found chemotherapy increased expression nuclear translocation in HepG2 cells, well p53 translocation. However, little is known functions during chemotherapy. Our results show overexpression of increases...
The relationship between tumor-associated macrophages (TAM) and epithelial-to-mesenchymal transition (EMT) during the initiation progression of metastasis is still unclear. Here, a role for vitamin D receptor (VDR) in was identified, as well TAMs EMT. First, expression level VDR examined clinical tissue from human patients with breast cancer or mouse model differential metastasis. These results revealed that negatively correlates cancer. Second, coculture VDR-overexpressing cells macrophage...
Objective: The aim of this study is to explore the cause miscarriage, providing risk assessment guide next pregnancy.Methods: Four hundred eighty-four products-of-conception (POC) samples were analyzed by single nucleotide polymorphism (SNP) array, and peripheral blood couples collected for karyotyping or fluorescence in situ hybridization (FISH) analysis.Results: sixty-eight 484 (96.7%) fresh POC successfully using SNP-array. rate clinically significant chromosomal abnormalities 58.3%...
JMJD3 (Jumonji domain containing-3), a histone H3 Lys27 (H3K27) demethylase, has been reported to be involved in the antigen-driven differentiation of germinal center B-cells. However, insight into mechanism DLBCL (Diffuse large B-cell lymphoma) progression remains poorly understood. In this study, we investigated subtype-specific JMJD3-dependent survival effects DLBCL. Our data showed that ABC subtype, silencing-down inhibited interferon regulatory factor 4 (IRF4) expression demethylase...
The staging system for patients with anaplastic thyroid cancer (ATC) was updated in the 8th edition of American Joint Committee on Cancer Staging Manual. A cut-off age 55 years stipulated as a prognostic factor differentiated cancer; however, not considered ATC patients. To this end, study investigated relationship between at diagnosis and prognosis patients.The clinical information acquired from Surveillance, Epidemiology, End Results Program public database. Youden's index X-tile analyses...
Objective To explore the relationship between outdoor lighting and sports development of myopia, to analyze effects exercise on diopter children with normal vision so as provide guidance for prevention treatment myopia in adolescents future. Methods A total 201 were divided into two groups according or not. Each group was randomly 4 groups: group, control indoor group. Among them, received moderate high intensity aerobic 3 times a week 60 min each time 12 months, while had study life during...
BACKGROUND Depression has gradually become a common psychological disorder among children and adolescents. in adolescents affects their physical mental development. Psychotherapy is considered to be one of the main treatment options for depressed However, our understanding global performance progress interventions depression (PIDCA) research limited. AIM To identify collaborative networks this field explore current status hotspots through bibliometrics. METHODS Articles reviews related PIDCA...
It has been reported that activating transcription factor 4 (ATF4) increases the processes of tumor growth, metastasis and drug resistance. However, role played by ATF4 in chemoresistance hepatocellular carcinoma (HCC) remains unknown. Clarification this HCC could greatly benefit efficacy clinical treatment HCC. In study, we found was overexpressed about 50.7% tissues. fact knockdown significantly increased cytotoxicity cisplatin both vitro vivo assays, while overexpression molecule...
Background: SH2B adaptor protein 2 (SH2B2, also named APS) is an implicated in the modulation of insulin signaling pathways and glucose metabolism. Its role colon adenocarcinoma (COAD) unknown. Methods: Data from The Cancer Genome Atlas Gene Expression Omnibus database were utilized to assess SH2B2 expression its clinical significance COAD. We investigated associations between with genomic instability, tumor mutational burden (TMB), DNA methylation, alternative splicing, immune infiltration,...
Currently, several gene-expression signatures that were used to predict survival of diffuse large B-cell lymphoma (DLBCL) patients, showed a restriction on the practical work for lack convenient operation. In this study, we screened inflammatory genes whose expression correlated with DLBCL and established predictive model including IL6, IL1A CSF3 through multivariate Cox regression based these three genes. We validated at protein level in our clinical serum cohort composed 101 patients 50...