A5101455408- Atrial Fibrillation Management and Outcomes
- Autoimmune Neurological Disorders and Treatments
- Cardiac Arrhythmias and Treatments
- Pancreatitis Pathology and Treatment
- Genetics and Neurodevelopmental Disorders
- Epilepsy research and treatment
- Stroke Rehabilitation and Recovery
- Peripheral Neuropathies and Disorders
- Ovarian function and disorders
- Liver Disease Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Genetic Neurodegenerative Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Transcranial Magnetic Stimulation Studies
- Sperm and Testicular Function
- Peroxisome Proliferator-Activated Receptors
- Hormonal and reproductive studies
- Cellular transport and secretion
- Reproductive Biology and Fertility
- Traditional Chinese Medicine Studies
- Ion Transport and Channel Regulation
- Sleep and Wakefulness Research
- Diabetes and associated disorders
First Affiliated Hospital of Xi'an Jiaotong University
2025
Capital Medical University
2019-2024
Chinese PLA General Hospital
2024
Chinese Institute for Brain Research
2024
Jilin Agricultural University
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Zhongshan Hospital
2024
Fudan University
2024
Sun Yat-sen University
2024
Sichuan University
2019-2022
<b><i>Background:</i></b> Not all adults with chronic insomnia respond to the recommended therapeutic options of cognitive behavioral therapy and approved hypnotic drugs. Transcranial alternating current stimulation (tACS) may offer a novel potential treatment modality for insomnia. <b><i>Objectives:</i></b> This study aimed examine efficacy safety tACS treating adult patients <b><i>Methods:</i></b> Sixty-two...
Abstract Mobile genetic elements play an important role in the acquisition of antibiotic and biocide resistance, especially through formation resistance islands bacterial chromosomes. We analyzed contribution Tn7-like transposons to island diversification nosocomial pathogen Acinetobacter baumannii identified four separate families that recognize different integration sites. One site is within comM gene coincides with previously described Tn6022 suggested account for AbaR island. established...
Some acute ischemic stroke (AIS) patients due to large-vessel occlusion, who underwent endovascular thrombectomy (EVT), continue experience unfavorable outcomes. Furthermore, the impact of internal carotid artery (ICA) tortuosity remains uncertain. This study aimed determine value ICA and clinical features in predicting 3-month outcome early neurological deterioration (END) after EVT AIS through nomograms. A total 313 treated with at First Affiliated Hospital Xi'an Jiaotong University were...
Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder prevalent in females of reproductive age; insulin resistance (IR) major pathogenic driver. Pharmacology a basic option for PCOS therapy; traditional Chinese medicine (TCM), as significant part complementary alternative medicine, has long history clinical management PCOS. Cangfudaotan decoction (CFD) been used clinically gynaecological diseases especially In this study, first, chemical components CFD were...
Abstract Background Ber, a Chinese herbal monomer has been reported to exhibit an array of pharmacological activities related the lowering blood glucose and treatment polycystic ovarian syndrome (PCOS). In present study, we aimed elucidate effect berberine (Ber) on rat model PCOS mediated via PI3K/AKT signaling pathway. Methods A animal was induced with administration letrozole, animals were then randomized into untreated or Ber metformin hydrochloride treated groups. After administration,...
Mutations in the Potassium channel subfamily T member 1 (KCNT1) gene have been reported a range of epileptic encephalopathies. Here we report case 12-year-old male suffering from multiple types seizures and cognitive decline age 10. The patient had four seizures, including tonic atypical absence myoclonic generalized tonic-clonic seizures. electroencephalogram showed slow spike-and-slow-waves, mutiple-spike-and-slow-waves, as well short-term fast rhythms bursts. Thus, he was diagnosed with...
Abstract Background The current evidence on the association between obesity-associated markers and semen quality, serum reproductive hormones lipids remains inconsistent. In this study, we tested hypothesis that, in infertile Chinese men, body mass index (BMI) negatively correlates with sperm concentration, total testosterone (TT), high-density lipoprotein cholesterol (HDL-C). relationship other quality parameters, hormones, leptin were also investigated. Methods 181 men recruited from...
The molecular mechanism of insulin resistance induced by high-fructose feeding is not fully understood. present study investigated the role downstream signaling molecules phosphatidylinositol 3-kinase (PI3K) in insulin-stimulated skeletal muscle high-fructose-fed rats. Rats were divided into chow-fed and fructose-fed groups. results euglycemic clamp (insulin infusion rates: 6 mU/kg BW/min) showed a significant decrease glucose rate (GIR) metabolic clearance (MCR) rats compared with In...
Erectile dysfunction (ED) is one of the significant complications diabetes mellitus (DM), and CASR plays an important role in cellular antiapoptosis NO production vascular endothelium by activating PKC. The present study was aimed to investigate efficacy Leech Centipede Granules (LCG) through CaSR/PLC/PKC signaling. Fifty male Sprague-Dawley rats were treated with streptozotocin induce DM model. After 10 weeks, apomorphine test used confirm DMED. Rats DMED administrated LCG U73122 for 4...
The crisis of male infertility is an issue human reproductive health worldwide. Wuzi Yanzong pill (WZYZP) a traditional Chinese medicine prescription that shows efficacy in kidney reinforcement and essence benefit to ameliorate dysfunctions. However, the pharmacological mechanisms WZYZP on have not been investigated clarified clearly. This study was designed investigate effects spermatogenesis disorder explore its underlying mechanisms. First, based network pharmacology study, 39 bioactive...
Abstract Background: Transcranial alternating current stimulation (tACS) offers a new approach for adult patients with major depressive disorder (MDD). The study is to evaluate the efficacy and safety of tACS treating MDD. Methods: This an 8-week, double-blind, randomized, placebo-controlled study. Ninety-two drug-naive MDD aged 18 65 years will receive 20 daily 40-min, 77.5-Hz, 15-mA sessions active or sham targeting forehead both mastoid areas on weekdays 4 consecutive weeks (week 4),...
Objective: To explore the efficacy, adverse reactions, feasibility, and acceptability of transcranial alternating current stimulation (tACS) treating drug-naive adult patients with major depressive disorder (MDD), provide basis for further study a large sample. Methods: The was performed in Neuromodulation laboratory, Department Neurology Xuanwu Hospital, Capital Medical University (Beijing, China) from July, 2017 to June, 2018. Thirty Eligible first-episode MDD outpatients were randomized...
Background Immune-mediated cerebellar ataxias (IMCAs) are common in paraneoplastic degeneration (PCD) but rarely occur patients with neuronal surface antibodies (NSAbs). Although (CAs) associated anti-NMDAR and anti-CASPR2 have been reported a few cases, they never studied systematically. This study aimed to analyze the characteristics of anti-NSAbs-associated CAs. Methods A retrospective investigation was conducted identify using keywords IMCAs NSAbs . We collected clinical data 14...