A5083853993- Ovarian function and disorders
- Sperm and Testicular Function
- Healthcare and Venom Research
- Reproductive System and Pregnancy
- Cancer-related molecular mechanisms research
- Reproductive Biology and Fertility
- Lipid metabolism and disorders
- Phytochemistry and biological activities of Ficus species
- Ginseng Biological Effects and Applications
- Natural Compounds in Disease Treatment
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Bariatric Surgery and Outcomes
- Morinda citrifolia extract uses
- Anesthesia and Neurotoxicity Research
- Genomics, phytochemicals, and oxidative stress
- Pharmacological Effects of Natural Compounds
- Medicinal Plant Pharmacodynamics Research
- Sunflower and Safflower Cultivation
- Sexual Differentiation and Disorders
- Reproductive Health and Technologies
- Diet, Metabolism, and Disease
- Hormonal and reproductive studies
- Liver Disease Diagnosis and Treatment
- Kruppel-like factors research
Integrated Chinese Medicine (China)
2014-2023
Zhejiang Hospital
2023
Hangzhou Red Cross Hospital
2009-2021
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2015
Aim: To explore the pattern of expression circulating miRNAs in patients with polycystic ovary syndrome (PCOS). Materials and methods: Microarray qRT-PCR were used to investigate PCOS during clinical diagnosis. The targets dys-regulated predicted using bioinformatics, followed by function pathway analysis databases Gene Ontology KEGG pathway. Results: BMI, triglyceride, HOMA-IR, Testosterone CRP levels significantly higher, while estradiol was lower than control groups. After SAM analysis, 5...
Objective: This study investigates the effects of CangFu Daotan Decoction (CDD) on m6A methylation and Wnt/β-catenin pathway in rats with polycystic ovary syndrome (PCOS).Methods: The PCOS rat model was established by letrozole gavage. were fed high-fat chow, their body weight blood glucose recorded. expressions follicle-stimulating hormone(FSH), luteinizing hormone(LH), testosterone(T) quantified ELISA. Chemical components CDD analyzed using UPLC-Q/TOF-MS. Based network pharmacology...
Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder prevalent in females of reproductive age; insulin resistance (IR) major pathogenic driver. Pharmacology a basic option for PCOS therapy; traditional Chinese medicine (TCM), as significant part complementary alternative medicine, has long history clinical management PCOS. Cangfudaotan decoction (CFD) been used clinically gynaecological diseases especially In this study, first, chemical components CFD were...
Abstract Background Ber, a Chinese herbal monomer has been reported to exhibit an array of pharmacological activities related the lowering blood glucose and treatment polycystic ovarian syndrome (PCOS). In present study, we aimed elucidate effect berberine (Ber) on rat model PCOS mediated via PI3K/AKT signaling pathway. Methods A animal was induced with administration letrozole, animals were then randomized into untreated or Ber metformin hydrochloride treated groups. After administration,...
Abstract Background The current evidence on the association between obesity-associated markers and semen quality, serum reproductive hormones lipids remains inconsistent. In this study, we tested hypothesis that, in infertile Chinese men, body mass index (BMI) negatively correlates with sperm concentration, total testosterone (TT), high-density lipoprotein cholesterol (HDL-C). relationship other quality parameters, hormones, leptin were also investigated. Methods 181 men recruited from...
The crisis of male infertility is an issue human reproductive health worldwide. Wuzi Yanzong pill (WZYZP) a traditional Chinese medicine prescription that shows efficacy in kidney reinforcement and essence benefit to ameliorate dysfunctions. However, the pharmacological mechanisms WZYZP on have not been investigated clarified clearly. This study was designed investigate effects spermatogenesis disorder explore its underlying mechanisms. First, based network pharmacology study, 39 bioactive...
Polycystic ovarian syndrome (PCOS) is a common disorder that leads to infertility in reproductive-aged females. HOTAIR highly expressed various gynecological diseases and associated with poor prognosis. We aimed explore the role of PCOS.First, PCOS rats were induced using dehydroepiandrosterone then treated si-HOTAIR. Next, mRNA expression serum hormone levels detected. HE staining was applied observe estrus cycle, morphology count number follicles. Apoptosis ovary detected by TUNEL....
Polycystic ovary syndrome (PCOS) is an endocrine disease associated with reproduction. The Cuscuta-Salvia formula has been widely used to treat for PCOS in clinic. However, its chemical and pharmacological properties remain unclear. We identified the active components related targets of using UHPLC-ESI-Q-TOF-MS TCMSP database. Disease were obtained from DisGeNET GeneCards databases. Subsequently, common between a Venn diagram. PPI network was established. Core genes selected Cytoscape...
Abstract Objective: Previous genome-wide sequencing revealed that Ras-related protein Rab-5B (RAB5B) is a susceptible target in patients with polycystic ovary syndrome (PCOS). Methods: Direct was performed to analyze the RAB5B gene rs1045435, rs11550558, rs34962186, rs705700, rs58717357, rs11171718, rs60028217, rs772920 loci genotypes 300 PCOS and healthy controls. The plasma microRNA (miRNA)-24, miR-320 levels were measured by reverse transcription fluorescent quantitative PCR (RT-qPCR)....
Abstract Kaempferol is the active ingredient of Er‐Xian decoction (EXD), a traditional Chinese medicine formula used clinically to treat ovarian dysfunction, but mechanism kaempferol relieving age‐related diminished reserve (AR‐DOR) still unclear. In this study, 36 volunteers and 78 DOR patients (37 with EXD treatment) were enrolled in clinical research. Meanwhile, 32‐week‐old female mice establish AR‐DOR model, these model intragastrically administered 100 mg/kg presence or absence 200...
Objective: Polycystic ovarian syndrome (PCOS) is a prevalent gynecologic disorder, often associated with abnormal follicular development. Cangfu Daotan decoction (CFD) traditional Chinese medicine formula that effective in alleviating PCOS clinically, but the specific mechanism remains unclear. Forkhead box K1 (FOXK1) cellular function. This study aimed to explore effects of CFD and FOXK1 on PCOS.Methods: High-fat diet letrozole were combined establish rat models. Next, primary GCs extracted...
Traditional Chinese Medicine (TCM) Cuscutae semen (SC, Tusizi from Cuscuta chinensis Lam.) and Lycii fructus (FL, Gouqi Lycium barbarum L.), are also used as a herb pair (SC-FL) to treat various ailments, including spermatogenic dysfunction (SD), disease responsible for low fertility in males. Herein, we will further determine the bioactive components, component targets partial molecular mechanisms of treatment SD. We employed traditional medicine systems pharmacology database combination...