A5101645316- Nutrition and Health in Aging
- Ovarian function and disorders
- Cancer, Hypoxia, and Metabolism
- Reproductive Biology and Fertility
- Acupuncture Treatment Research Studies
- Cancer Genomics and Diagnostics
- Healthcare and Venom Research
- Nuclear Structure and Function
- Lipid metabolism and disorders
- Reproductive Health and Technologies
- Metabolism, Diabetes, and Cancer
- Assisted Reproductive Technology and Twin Pregnancy
- Childhood Cancer Survivors' Quality of Life
- Lung Cancer Treatments and Mutations
- Cancer Treatment and Pharmacology
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Galectins and Cancer Biology
- Body Composition Measurement Techniques
- Advanced Breast Cancer Therapies
- Phytochemistry and biological activities of Ficus species
- Hereditary Neurological Disorders
- Cancer survivorship and care
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
Tianjin University of Traditional Chinese Medicine
2019-2025
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2017-2025
National Clinical Research
2025
Sorrento Therapeutics (United States)
2023
Beijing University of Chinese Medicine
2021-2022
Shangqiu First People's Hospital
2021
Helsinn Therapeutics (United States)
2012-2016
China Academy of Chinese Medical Sciences
2016
Hangzhou Hospital of Traditional Chinese Medicine
2015
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2015
<h3>Importance</h3> Acupuncture is used to induce ovulation in some women with polycystic ovary syndrome, without supporting clinical evidence. <h3>Objective</h3> To assess whether active acupuncture, either alone or combined clomiphene, increases the likelihood of live births among syndrome. <h3>Design, Setting, and Participants</h3> A double-blind (clomiphene vs placebo), single-blind (active control acupuncture) factorial trial was conducted at 21 sites (27 hospitals) mainland China...
Abstract Background Our study aims to evaluate the expression of TLR9 in glioma tissues, examine association between expression, clinicopathological variables, and patient outcome, we further characterized direct effects agonist CpG ODN upon proliferation invasion cells vitro . Methods RT-PCR immunofluorescence were used determine cell lines clinical samples. Tissue microarry immunohistochemistry applied evaluated 292 newly diagnosed 13 non-neoplastic brain tissues. We investigated effect on...
To observe the effect of acupuncture on oxeiptosis Kelch-like ECH-associated protein 1 (KEAP1)/phosphoglycerate mutase 5 (PGAM5)/mitochondrial apoptosis-inducing factor (AIFM1) signaling pathway in rats with diminished ovarian reserve (DOR), so as to explore possible mechanisms by which improves function DOR rats. Female SD were randomly divided into control group, model and 6 each group. The was established one-time intraperitoneal injection 75 mg/kg cyclophosphamide. After modeling, group...
// Parthasarathy Seshacharyulu 1 , Moorthy P. Ponnusamy Satyanarayana Rachagani Imayavaramban Lakshmanan Dhanya Haridas Ying Yan 2,3 Apar K. Ganti 4 and Surinder Batra 1,2 Department of Biochemistry Molecular Biology, University Nebraska Medical Center, Omaha, NE, USA 2 Fred Pamela Buffett Cancer Eppley Institute for Research in Allied Diseases, 3 Radiation Oncology, Internal Medicine, VA Nebraska-Western Iowa Health Care System Correspondence: Batra, email: Keywords : Afatinib, Canertinib,...
In randomized studies involving severely ill patients, functional outcomes are often unobserved due to missed clinic visits, premature withdrawal, or death. It is well known that if these not handled properly, biased treatment comparisons can be produced. this article, we propose a procedure for comparing treatments based on composite endpoint combines information both the outcome and survival. We further missing data imputation scheme sensitivity analysis strategy handle Illustrations of...
Does second-hand smoke (SHS) exposure from husbands have adverse effects on sex hormones, metabolic profiles, clinical phenotypes and fertility outcomes in women with polycystic ovary syndrome (PCOS) undergoing ovulation induction?SHS is associated worsened biochemical hyperandrogenism, higher incidence of reduced conception rates PCOS.Smoking impairs fecundity at some stages the reproductive process including folliculogenesis, embryo transport, endometrial angiogenesis uterine blood flow....
Cancer anorexia-cachexia syndrome (CACS) is common in advanced cancer patients and associated with weight loss, fatigue, impaired quality of life (QoL), poor prognosis. The goal this project was to identify the most responsive items from two QoL measures ROMANA 2 (NCT01387282) phase III global study evaluating anamorelin HCl treatment non-small cell lung (NSCLC) cachexia: Functional Assessment Chronic Illness Therapy-Fatigue (FACIT-F) Anorexia/Cachexia Therapy (FAACT).In trial, 477...
Abstract We explored the independent risk factors associated with cases of spontaneous abortion in infertile patients treated human-assisted reproductive technology (ART) and established a smooth curve fit perform threshold effect analysis can provide guidance valuable reference for predicting probability abortion. This was retrospective cohort study 16,097 successfully conceived ART Shangqiu First People's Hospital from June 2013 to December 2018. Overall, 2,378 (14.77%) had an 13,719...
Objective The objective of this study was to explore the risk factors ovarian hyperstimulation syndrome (OHSS) in patients with polycystic ovary (PCOS) undergoing vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) and establish a nomogram model evaluate probability OHSS PCOS patients. Methods We retrospectively analyzed clinical data from 4,351 receiving IVF/ICSI our reproductive medical center. cases were randomly divided into modeling group (3,231 cases) verification (1,120...
Purpose/Objective(s)Cancer anorexia-cachexia syndrome (CACS) is a multifactorial condition with high prevalence in non-small cell lung cancer (NSCLC). CACS characterized by decreased body weight (mainly lean mass; LBM), and associated worsened morbidity survival. Standard effective treatments are lacking. Anamorelin HCl (ANAM) novel, selective ghrelin receptor agonist appetite-enhancing anabolic activity.Materials/MethodsROMANA 1 (NCT01387269) was an international, double-blind, randomized...
e20715 Background: Cancer anorexia-cachexia syndrome is a multifactorial condition, characterized by decreased body weight (mainly loss of lean mass), which often occurs in patients with advanced non-small cell lung cancer (NSCLC) and associated poor prognosis impaired quality life. Anamorelin HCl (ANAM) novel, oral selective ghrelin receptor agonist appetite-enhancing anabolic activity. Methods: ROMANA 1 2 (NCT01387269 NCT01387282) are two global, double-blind, randomized, Phase 3 trials,...
TPS5106 Background: Abivertinib is a potent, small molecule third-generation tyrosine kinase inhibitor (TKI) of epidermal growth factor receptor (EGFR), Bruton (BTK) receptor, and bone marrow gene on chromosome X (BMX). irreversibly binds to the BTK preventing phosphorylation also BMX. The adrenal-permissive HSD3B1(1245C) allele, which present in upwards 50% men with prostate cancer, encodes 3βHSD1 enzyme missense that up-regulates rate-limiting step androgen biosynthesis from extragonadal...
6 Background: Cancer anorexia-cachexia syndrome (CACS), often observed in NSCLC patients, is characterized by decreased body weight, mainly lean mass (LBM), and associated with worse morbidity survival. Anamorelin HCl (ANAM), a novel selective ghrelin receptor agonist appetite-enhancing anabolic activity, development as treatment of CACS. Methods: ROMANA 2 was one two global, double-blind, Phase III trials assessing ANAM efficacy safety NSCLC. Patients unresectable stage III/IV NSCLC, ECOG...
Objective To investigate the effect of lead aVR on recent prognosis in patients with non-ST-elevation acutecoronary syndrome(NSTE-ACS). Methods 195 NSTE-ACS were divided into ST segment elevation group(n=54 cases) and non-ST group(n=141) according to admission; clinical data, laboratory index coronary artery lesion recorded, major adverse cardiac (MACE) hospitalization time also recorded. Results Compared group, heart rate group was faster[(85.4±12.0) beats per minute...
42 Background: Anamorelin HCl (ANA) is an oral ghrelin receptor agonist in development for non-small cell lung cancer (NSCLC)-associated anorexia/cachexia. Cancer cachexia a multifactorial syndrome, characterized by decreased body weight and muscle, worsened survival quality of life (QoL). Here we present Phase II data, including evaluation QoL using the MD Anderson Symptom Inventory (MDASI) to assess severity core symptoms patients their impact on daily life. Methods: An international,...
Abstract Anti-cancer drugs, either targeted therapies or cytotoxic chemotherapies, have proven to be effective in treating certain cancer patients. However, most cases, tumors recur and become resistant the treatment after a period of time. There are urgent needs understand underlying drug resistance mechanisms, discover targets biomarkers develop new combination tackle this widely occurring clinical problem. Currently main approaches study include analyzing samples developing models vitro....