A5101691273- Cancer-related Molecular Pathways
- Ginseng Biological Effects and Applications
- Ubiquitin and proteasome pathways
- Natural product bioactivities and synthesis
- Cancer-related molecular mechanisms research
- Developmental Biology and Gene Regulation
- Epigenetics and DNA Methylation
- Microtubule and mitosis dynamics
- DNA Repair Mechanisms
- Pharmacological Effects of Natural Compounds
- Hedgehog Signaling Pathway Studies
- Retinoids in leukemia and cellular processes
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- Genomics and Chromatin Dynamics
- Nerve injury and regeneration
- Cancer-related gene regulation
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Hippo pathway signaling and YAP/TAZ
- Chronic Lymphocytic Leukemia Research
- RNA Research and Splicing
- Ocular Oncology and Treatments
- Cellular transport and secretion
Nanjing Forestry University
2023-2025
Hebei Medical University
2015-2024
Fourth Hospital of Hebei Medical University
2015-2024
East China University of Science and Technology
2024
China National Institute of Standardization
2024
Guangxi University
2024
Guangxi University of Chinese Medicine
2024
Sun Yat-sen University
2024
Sun Yat-sen University Cancer Center
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Diffuse large B-cell lymphomas (DLBCLs) are phenotypically and genetically heterogeneous. Gene-expression profiling has identified subgroups of DLBCL (activated B-cell–like [ABC], germinal-center [GCB], unclassified) according to cell origin that associated with a differential response chemotherapy targeted agents. We sought extend these findings by identifying genetic subtypes based on shared genomic abnormalities uncover therapeutic vulnerabilities tumor genetics.
Genetic studies have shown that cyclin E and dE2F are critical regulators of S-phase entry during Drosophila embryogenesis. Whereas the ectopic expression activates dE2F-dependent transcription, it has been proposed does not act directly on but targets a negative regulator E2F activity. Such might be analogous to family RB-related proteins (pRB, p107, p130) associate with in humans; however, extensive efforts failed find such homologs Drosophila. We developed two-hybrid approach allows...
Soybean isoflavones have been used as a potential preventive agent in anticancer research for many years. Genistein is one of the most active flavonoids soybeans. Accumulating evidence suggests that genistein alters variety biological processes estrogen-related malignancies, such breast and prostate cancers. However, molecular mechanism prevention human colon cancer remains unclear. Here we attempted to elucidate anticarcinogenic cells. First evaluated growth inhibitory effect two other...
Diffuse large B cell lymphomas (DLBCLs) arise from proliferating cells transiting different stages of the germinal center reaction. In activated DLBCLs (ABC-DLBCLs), a class that respond poorly to current therapies, chromosomal translocations and amplification lead constitutive expression lymphoma 6 (BCL6) oncogene. The role BCL6 in maintaining these has not been investigated. Here, we designed small-molecule inhibitors display higher affinity for than its endogenous corepressor ligands...
Abstract The goal of the present study was to elucidate mechanism by which long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (lncRNA MALAT1) promotes inflammation in Parkinson’s disease (PD). 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) used induce PD development C57BL/6 mice, and tyrosine hydroxylase (TH) expression analysed immunohistochemical analysis. Western blot qPCR analyses were conducted assess protein mRNA levels, respectively....
Compound K (20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol, CK), an intestinal bacterial metabolite of ginseng protopanaxadiol saponins, has been shown to inhibit cell growth in a variety cancers. However, the mechanisms are not completely understood, especially colorectal cancer (CRC). A xenograft tumor model was used first examine anti-CRC effect CK vivo. Then, multiple vitro assays were applied investigate anticancer effects including antiproliferation, apoptosis and cycle distribution....
Tripyrrole molecules have received renewed attention due to reports of numerous biological activities, including antifungal, antibacterial, antiprotozoal, antimalarial, immunosuppressive, and anticancer activities. In a screen bacterial strains with known toxicities termites, red pigment-producing strain, HDZK-BYSB107, was isolated from Chamaecyparis lawsoniana, which grows in Oregon, USA. Strain HDZK-BYSB107 identified as Serratia marcescens subsp. lawsoniana. The pigment prodigiosin using...
Schwann cells are the main supportive of peripheral nerves. suffer inhibition autophagy under hyperglycemia treatment in diabetic neuropathy (DPN). However, exact mechanism is still not fully elucidated. We first observed decrease markers (LC3-II/LC3-I, P62) sciatic nerves mice vs. normal mice, accompanied with loss myelinated nerve fibers and abnormal myelin sheath. In line this, LC3-II/LC3-I P62 were also significantly reduced high glucose—treated rat cell 96 (RSC96) compared cells....
Medulloblastoma, the most common malignant brain tumor of childhood, is believed to derive from immature granule neuron precursors (GNPs) that normally proliferate in external layer before exiting cell cycle and migrating their mature location inner layer. In this study, we examined expression D type cyclins GNPs during cerebellar development showed early expressed only cyclin D1, whereas later both D1 D2. Coinciding with period D1-only expression, Ccnd1-/- mice reduced proliferation...
New genes can originate by the combination of sequences from unrelated or their duplicates to form a chimeric structure. These often evolve rapidly, suggesting that they undergo adaptive evolution and may therefore be involved in novel phenotypes. Their functions, however, are rarely known. Here, we describe phenotypic effects gene, sphinx , has recently evolved Drosophila melanogaster . We show knockout this gene leads increased male–male courtship D. although it leaves other aspects mating...
American ginseng (Panax quinquefolius L., Araliaceae) possesses anti-cancer potential and is one of the most commonly used herbal medicines in United States. Ginsenoside Rg3, saponins ginseng, has been shown to inhibit tumor growth. In this study, we sought characterize downstream genes targeted by extracts HCT-116 human colorectal cancer cells. We first demonstrated that content Rg3 steamed at 120°C for 2 h (referred as S2h) was significantly increased when compared with unsteamed ginseng....