A5024729038- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Circadian rhythm and melatonin
- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Natural product bioactivities and synthesis
- Contact Dermatitis and Allergies
- Transgenic Plants and Applications
- Eicosanoids and Hypertension Pharmacology
- Eating Disorders and Behaviors
- Cancer, Lipids, and Metabolism
- Child Nutrition and Feeding Issues
- Urticaria and Related Conditions
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Sleep and related disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood Pressure and Hypertension Studies
- Viral gastroenteritis research and epidemiology
- Pediatric health and respiratory diseases
- Amphibian and Reptile Biology
- Respiratory and Cough-Related Research
- Health, psychology, and well-being
Lurie Children's Hospital
2016-2025
Northwestern University
2015-2024
Beth Israel Deaconess Medical Center
2019-2020
Harvard University
2019-2020
Center for Vascular Biology Research
2019-2020
Hadassah Medical Center
2020
Circadian (United States)
2018
Georgetown University
2017
Philipps University of Marburg
2015
Hospital Doctor José Molina Orosa
2015
Atopic dermatitis (AD) is associated with chronic itch, allergic disease and sleep disturbance, all of which might increase the risk attention deficit (hyperactivity) disorder (ADD/ADHD). Previous analyses have found a consistent association between AD ADD/ADHD, although underlying factors contributing to such an remain underexplored. Additionally, relationship has been underexplored in adults. To determine if childhood adult severity are ADD/ADHD delineate association. We analysed data on...
Cancer therapy is a double-edged sword, as surgery and chemotherapy can induce an inflammatory/immunosuppressive injury response that promotes dormancy escape tumor recurrence. We hypothesized these events could be altered by early blockade of the inflammatory cascade and/or accelerating resolution inflammation. Preoperative, but not postoperative, administration nonsteroidal antiinflammatory drug ketorolac resolvins, family specialized proresolving autacoid mediators, eliminated...
Little is known about the impact of sleep disturbances (SD) or sleep-related impairment (SRI) in adults with AD their relationship severity and itch other predictors.
Significance Eicosanoid and cytokine storms are poorly characterized in cancer. Our study demonstrates the environmental carcinogen aflatoxin B 1 (AFB ) promotes hepatocellular carcinoma (HCC) by triggering a debris-stimulated proinflammatory proangiogenic “eicosanoid storm” tumor microenvironment. The dual COX-2/sEH inhibitor PTUPB prevents AFB -stimulated HCC growth increasing macrophage phagocytosis of debris suppressing eicosanoid storm, thus promoting resolution inflammation. Enhancing...
We report the development of a skin-conformable wireless sensor capable assessing scratching for quantification itch.
Food allergy affects approximately 6-8% of children, and increasing in prevalence. Some children naturally outgrow their food without intervention, but the mechanisms by which this occurs remain poorly understood. We sought to investigate role regulatory T cells development acquired tolerance.Fifty-eight (1-18 years) with either egg or peanut allergy, recent acquisition natural tolerance peanut, no were studied. Peripheral blood mononuclear (PBMC) from these groups stimulated relevant...
Abstract The chemical constituents and antiproliferative effects on SW480 human colorectal cancer cells of different plant parts P. notoginseng were evaluated. contents saponins in extracts from root, rhizome, flower berry determined using high performance liquid chromatography. proportions among the four parts. Using cell counting method, evaluated results indicated all extracts, at 0.05–1.0 mg/mL, showed concentration‐related cells. extract had stronger compared with other three extracts;...
In this study, we evaluated the effects of Panax notoginseng root extract (NGRE) and its major constituents on SW480 human colorectal cancer cells. We used high performance liquid chromatography to determine contents saponins in NGRE. The anti-proliferative were by cell counting method, concentration-related observed. At 1.0 mg/ml, NGRE inhibited growth 85.8% (P<0.01), probably linked higher concentration ginsenosides Rb1 Rg1. pharmacologic activities notoginsenoside R1 Rg1 cells...