A5085720122- Pulsed Power Technology Applications
- Ginseng Biological Effects and Applications
- Laser-Plasma Interactions and Diagnostics
- Gyrotron and Vacuum Electronics Research
- Pharmacological Effects of Natural Compounds
- Silicone and Siloxane Chemistry
- Electromagnetic Launch and Propulsion Technology
- Electrostatic Discharge in Electronics
- Gut microbiota and health
- Proteins in Food Systems
- Particle accelerators and beam dynamics
- Phytochemicals and Antioxidant Activities
- Natural product bioactivities and synthesis
- Marine Biology and Environmental Chemistry
- High voltage insulation and dielectric phenomena
- Collagen: Extraction and Characterization
- Iron Metabolism and Disorders
- Advanced Chemical Sensor Technologies
- Lipid metabolism and disorders
- Particle Accelerators and Free-Electron Lasers
- Plant Micronutrient Interactions and Effects
- Trace Elements in Health
- Lightning and Electromagnetic Phenomena
- Dye analysis and toxicity
- Protein Hydrolysis and Bioactive Peptides
Northwest University
2016-2025
Institute of Vegetables and Flowers
2022-2025
Chinese Academy of Agricultural Sciences
2022-2025
China University of Mining and Technology
2008-2025
Chinese Academy of Engineering
2004-2025
Tsinghua University
2002-2024
North Sichuan Medical University
2024
Sichuan Mianyang 404 Hospital
2014-2024
Sichuan University
2024
West China Second University Hospital of Sichuan University
2024
Plant polyphenols play an essential role in human health. The bioactivity of depends not only on their content but also bioavailability food. processing techniques, especially non-thermal processing, improve the retention and polyphenolic substances. However, there are limited studies summarizing relationship between polyphenols, potential mechanisms. This review aims to summarize effects techniques fruits vegetables. Importantly, disruption cell walls membranes, inhibition enzyme...
Background and Purpose Nuciferine, an alkaloid found in Nelumbo nucifera leaves, alleviates dyslipidemia vivo . However, whether it improves liver injury diabetic conditions the underlying mechanism is unclear. The present study aimed to investigate effects of nuciferine on lipid glucose metabolism a murine model Type 2 diabetes mellitus (T2DM) determine mechanisms these effects. Experimental Approach A T2DM was induced by high‐fat diet (HFD) feeding combined with streptozocin (STZ)...
Ginsenoside Rk3 (G-Rk3) is a main active ingredient of ginsenosides. Several recent studies demonstrated that ginsenosides have potential anti-type 2 diabetes mellitus (T2DM) properties. To evaluate the anti-T2DM effect G-Rk3 and verify its mechanism, high-fat-diet/streptozocin (HFD/STZ) induced model T2DM in C57BL/6 mice high glucose insulin resistance HepG2 cells were applied this research. Our analysis indicated reduced HFD/STZ hyperglycemia, serum inflammation levels, ameliorated...
Procyanidins, commonly found in plant natural sources, are polymerized forms of flavanols, which a subclass flavonoids. They have been reported to exhibit broad benefits human health and used the prevention cancers, cardiovascular diseases, diabetes, etc. Bioactivities procyanidins depend on many factors including structures procyanidins. Differences composition monomers degree polymerization (DP) contribute variation The basic sources summarized detail. Importantly, structure-activity...
Dysbiosis of the gut microbiota is emerging as a pivotal factor in pathogenesis colorectal cancer (CRC). Ginsenoside Rh4 (Rh4) an active compound isolated from ginseng with beneficial effects modulating intestinal inflammation and dysbiosis, but how regulates to alleviate CRC remains underexplored. We investigated impact on mechanism its action inhibiting via modulation microbiota. used AOM/DSS model employed transcriptomics, genomics metabolomics techniques explore inhibitory CRC....
Ginsenoside is a major active component of ginseng, which exhibits various pharmacological properties such as hepatoprotection, tumor suppression and diabetes resistance. In this study, the anti-diabetic effects protopanaxadiol (PPD) protopanaxatriol (PPT)-type saponins were explored compared in high-fat diet/streptozocin-induced type 2 mellitus (T2DM) mice. Our results showed that low or high dose (50 mg/kg bodyweight 150 bodyweight) PPD PPT significantly reduced fasting blood glucose,...
Significance Eicosanoid and cytokine storms are poorly characterized in cancer. Our study demonstrates the environmental carcinogen aflatoxin B 1 (AFB ) promotes hepatocellular carcinoma (HCC) by triggering a debris-stimulated proinflammatory proangiogenic “eicosanoid storm” tumor microenvironment. The dual COX-2/sEH inhibitor PTUPB prevents AFB -stimulated HCC growth increasing macrophage phagocytosis of debris suppressing eicosanoid storm, thus promoting resolution inflammation. Enhancing...
In this study, we aimed to investigate the influence of ginsenoside Rg5 (Rg5) on gut microbiota in diabetic db/db mice. Our data indicated that not only improved symptoms hyperglycemia, repaired intestinal barrier function, and relieved metabolic endotoxemia-related inflammation but also reversed dysbiosis colon with significantly decreased Firmicutes/Bacteroidetes ratios. More importantly, effects were further confirmed by partial changes induced broad-spectrum antibiotics. These findings...
STING is a core adaptor in innate nucleic acid sensing mammalian cells, on which different pathways converge to induce type I interferon (IFN) production. Particularly, activated by 2′3′-cGAMP, cyclic dinucleotide containing mixed phosphodiester linkages and produced cytoplasmic DNA sensor cGAS. Here, we reported novel transcript isoform of designated STING-β that dominantly inhibits sensing. without transmembrane domains was widely expressed at low levels various human tissues viral...
Obesity-induced colonic inflammation-stimulated colitis is one of the main causes colorectal cancer. Dietary phytochemicals are considered to be an effective strategy for relieving obesity-induced inflammatory diseases such as diabetes and colitis. Ginsenoside Rk3 (Rk3) bioactive component ginseng. Our previous study has demonstrated that can effectively alleviate type 2 diabetes, but whether it plays a beneficial role in remains poorly understood. Here, we found intervention repaired...