We extend the analysis of a physical model within standard cosmology that robustly predicts high star-formation efficiency (SFE) in massive galaxies at cosmic dawn due to feedback-free starbursts (FFBs). This implies an excess bright $z 10$ compared models based on low SFE later epochs, is indicated by JWST observations. Here we provide observable predictions galaxy properties analytic FFB scenario. These can be with simulations and use approximate as function redshift mass, assuming maximum...

Red Asian ginseng ( Panax C. A. Meyer, Araliaceae) is used in many Oriental countries. In this study, the saponin constituents and anticancer activities of steamed American quinquefolius L.) roots were evaluated. The contents 12 ginsenosides determined using high performance liquid chromatography (HPLC). After steaming treatment (100 - 120 degrees C for 1 h 0.5 4 h), quantity 7 decreased that 5 others increased. content ginsenoside Rg3, a previously recognized compound, increased...

This study was designed to determine the changes in saponin content American ginseng berries after treatment by heating and assess anticancer effects of extracts. After steaming (100−120 °C for 1 h, 120 0.5−4 h), seven ginsenosides, Rg1, Re, Rb1, Rc, Rb2, Rb3, Rd, decreased; five Rh1, Rg2, 20R-Rg2, Rg3, Rh2, increased. a previously identified ginsenoside, increased significantly. Two hours at ginsenoside Rg3 greater degree than other tested ginsenosides. When human colorectal cancer cells...

Valerian is a medicinal herb that produces anxiolytic and sedative effects. It was suggested valerian acts via gamma-aminobutyric acid (GABA)ergic mechanisms. Previous studies showed binding of extract to GABA receptors, but the functional effect has not been demonstrated. In this study we evaluated GABAergic one its major constituents, valerenic acid, on brainstem neuronal activity in an vitro neonatal rat preparation. We first observed muscimol, GABA(A) receptor agonist, decreased firing...

ABSTRACT We study the effects of Kelvin–Helmholtz Instability (KHI) on cold streams that feed massive haloes at high redshift, generalizing our earlier results to include radiative cooling and heating from a UV background, using analytic models resolution idealized simulations. currently do not consider self-shielding, thermal conduction, or gravity. A key parameter in determining fate is ratio time turbulent mixing layer which forms between stream background following onset instability,...

We forecast the number of galaxy clusters that can be detected via thermal Sunyaev-Zeldovich (tSZ) signals by future cosmic microwave background (CMB) experiments, primarily wide area survey CMB-S4 experiment but also CMB-S4's smaller delensing and proposed CMB-HD experiment. predict will detect 75,000 with its $f_{\rm sky}$ = 50% 14,000 deep 3%. Of these, approximately 1350 at $z \ge 2$, a regime is difficult to probe optical or X-ray surveys. assume same sky as S4-Wide{}, find $\times3$...

We study the effects of Kelvin-Helmholtz instability (KHI) on cold streams that feed high-redshift galaxies through their hot haloes, generalizing our earlier analyses a 2D slab to 3D cylinder, but still limiting analysis adiabatic case with no gravity. combine analytic modeling and numerical simulations in linear non-linear regimes. For subsonic or transonic respect halo sound speed, is qualitatively similar 2D, progresses at faster pace. supersonic streams, grows much can be different due...

Abstract The chemical constituents and antiproliferative effects on SW480 human colorectal cancer cells of different plant parts P. notoginseng were evaluated. contents saponins in extracts from root, rhizome, flower berry determined using high performance liquid chromatography. proportions among the four parts. Using cell counting method, evaluated results indicated all extracts, at 0.05–1.0 mg/mL, showed concentration‐related cells. extract had stronger compared with other three extracts;...

ABSTRACT Recent advances in simulations and observations of galaxy clusters suggest that there exists a physical outer boundary massive cluster-size dark matter (DM) haloes. In this work, we investigate the locations boundaries DM gas around haloes, by analysing sample 65 haloes extracted from Omega500 zoom-in hydrodynamical cosmological simulations. We show location accretion shock is offset splashback radius, contrary to prediction self-similar models. The radius larger than all...

In this study, we evaluated antihyperglycemic effects of American ginseng berry extract in diabetic ob/ob mice. Animals received daily intraperitoneal (IP) injections the 150 mg/kg for 12 days. On days 5 and 12, extract-treated mice had significantly lower fasting blood glucose levels compared to day 0 (both p < 0.05). Glucose tolerance improved significantly, which was shown by overall excursion, calculated as area under curve (AUC) during two-hour IP test. The AUC decreased 31.8% on (p...

ABSTRACT: Diabetes is a serious chronic metabolic disease and has significant impact on patients' lives the health care system. We previously observed that organic solvent extract of American ginseng berry possessed antidiabetic effects in obese diabetic ob / mice after intraperitoneal injection. If useful as dietary supplement, simple preparation oral intake would be convenient, safe, practical means for consumers. In this study, simply prepared juice was first analyzed using...

We present an analytic toy model for the radiation produced by interaction between cold streams thought to feed massive halos at high redshift and their hot CGM. begin deriving cosmologically motivated parameters as they enter halo virial radius, $R_{\rm v}$, a function of mass redshift. For $10^{12}M_{\odot}$ $z=2$, we find Hydrogen number density in be $n_{\rm H,s}\sim (0.1-5)\times 10^{-2}{\rm cm}^{-3}$, factor $\delta \sim (30-300)$ times denser than CGM density, while stream radii are...

Pain is considered the most common complaint worldwide for which patients seek treatment. Conventional analgesic agents play an important role in modern pain therapy, but they cause several adverse effects. Therefore, newer and better analgesics continue to be investigated. In this controlled clinical trial, authors evaluated effects of 2 herbal medicines, Corydalis yanhusuo Angelicae dahuricae. They used cold-pressor test-a simple, reliable, widely model humans-for induction tonic pain....

In this study, we evaluated the effects of Panax notoginseng root extract (NGRE) and its major constituents on SW480 human colorectal cancer cells. We used high performance liquid chromatography to determine contents saponins in NGRE. The anti-proliferative were by cell counting method, concentration-related observed. At 1.0 mg/ml, NGRE inhibited growth 85.8% (P<0.01), probably linked higher concentration ginsenosides Rb1 Rg1. pharmacologic activities notoginsenoside R1 Rg1 cells...

The phase space structure of dark matter halos can be used to measure the mass halo, infer accretion rates, and probe effects modified gravity. Previous studies showed that splashback radius measured in position using slope density profile. Using N-body simulations, we show halo does not end at this radius. Instead, there exists a region where infalling, splashback, virialized are mixed spatially. We model distribution three kinematically distinct populations an "edge radius" beyond which...