Kai Zhang

ORCID: 0000-0002-5289-3619
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Research Areas
  • Prostate Cancer Diagnosis and Treatment
  • Prostate Cancer Treatment and Research
  • Radiomics and Machine Learning in Medical Imaging
  • Lung Cancer Diagnosis and Treatment
  • Spine and Intervertebral Disc Pathology
  • Microbial Inactivation Methods
  • Gallbladder and Bile Duct Disorders
  • Spinal Fractures and Fixation Techniques
  • Lung Cancer Treatments and Mutations
  • Medical Imaging and Analysis
  • Gastric Cancer Management and Outcomes
  • MRI in cancer diagnosis
  • Pediatric Hepatobiliary Diseases and Treatments
  • Sarcoma Diagnosis and Treatment
  • Advanced Breast Cancer Therapies
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Musculoskeletal pain and rehabilitation
  • Pancreatic and Hepatic Oncology Research
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Aortic Disease and Treatment Approaches
  • Metastasis and carcinoma case studies
  • Cancer Mechanisms and Therapy
  • Aortic aneurysm repair treatments
  • Lung Cancer Research Studies
  • Urologic and reproductive health conditions

First Affiliated Hospital of Guangzhou Medical University
2025

Guangzhou Medical University
2025

Shandong University of Finance and Economics
2022-2025

Northwestern University
2024-2025

Zhengzhou University
2021-2025

The Fourth People's Hospital
2025

Inner Mongolia People's Hospital
2023-2024

Beijing United Family Hospital
2018-2024

Beijing Tian Tan Hospital
2018-2024

Capital Medical University
2018-2024

Adding radiotherapy (RT) to systemic therapy improves progression-free survival (PFS) and overall (OS) in oligometastatic non-small cell lung cancer (NSCLC). Whether these findings translate epidermal growth factor receptor (EGFR)-mutated NSCLC remains unknown. The SINDAS trial (NCT02893332) evaluated first-line tyrosine kinase inhibitor (TKI) for EGFR-mutated synchronous randomized upfront RT vs no RT; we now report the prespecified interim analysis at 68% accrual.Inclusion criteria were...

10.1093/jnci/djac015 article EN cc-by-nc-nd JNCI Journal of the National Cancer Institute 2022-01-25

We report final results with extended follow-up from a global, expanded-access trial that pre-regulatory approval provided sunitinib to metastatic renal cell carcinoma (mRCC) patients, ineligible for registration-directed trials. Patients ⩾18 years received oral 50 mg per day on 4-weeks-on–2-weeks-off schedule. Safety was assessed regularly. Tumour measurements were scheduled local practice. A total of 4543 patients sunitinib. Median treatment duration and 7.5 13.6 months. Objective response...

10.1038/bjc.2015.196 article EN cc-by British Journal of Cancer 2015-06-01

Abstract Background Irreversible electroporation (IRE) is a novel technique to treat localized prostate cancer with the aim of achieving oncological control while reducing related side effects. We present outcomes treated IRE from multi-center prospective registry. Methods Men histologically confirmed were recruited receive IRE. All patients proposed for biopsy at 1-year post-IRE ablation. The functional measured by International Prostate Symptom Score (IPSS) and Index Erectile Function...

10.1038/s41391-023-00783-y article EN cc-by Prostate Cancer and Prostatic Diseases 2024-01-09

Influenced by the hydrogeological structure and other factors, change in groundwater depth shows seasonal fluctuation characteristics. Human activities have disrupted long-term stable pattern of change, which makes short-term prediction important. To cope with emergence scenarios, for first time, a discrete grey model fractional order accumulation is proposed this paper (FDGSM(1,1)). First, DGM(1,1) model, has relative advantage over fluctuating data, was chosen as basis transformation...

10.3390/fractalfract9020117 article EN cc-by Fractal and Fractional 2025-02-13

To investigate the prognostic potential of preoperative blood neutrophil to lymphocyte ratio (NLR), hematocrit (HCT) and Fibrinogen (FIB) level in patients with colorectal cancer (CRC). The data 268 CRC who underwent radical surgery from March 2013 August 2017 First Affiliated Hospital Guangzhou Medical University (Guangzhou, China) were retrospectively collected. correlations between NLR, HCT FIB clinicopathologic features prognosis explored by Cox regression CRC. Univariate multivariate...

10.1080/17520363.2025.2473310 article EN Biomarkers in Medicine 2025-03-04

This study aimed to investigate the effects of total antioxidant capacity (T-AOC), superoxide dismu-tase (SOD), and malondialdehyde (MDA) in blood on postoperative wound healing process patients with severe burns treated by Meek micrografting. In total, 154 who underwent micrografting treatment were selected as observation group, 80 healthy people taken control group. General clinical data collected, serum T-AOC, SOD, MDA analyzed biochemical analysis. The group further divided into high...

10.7754/clin.lab.2024.240816 article EN Clinical Laboratory 2025-01-01

To investigate the diagnostic value of magnetic resonance imaging (MRI) for persistent prostate cancer after irreversible electroporation (IRE) therapy. This is a post hoc analysis from multicentre randomised trial, in which men with localised low- to intermediate-risk were receive either focal or extended IRE ablation. All patients underwent repeat MRI scans at 6 and 12 months transperineal template mapping biopsy (TMB) post-IRE. The sensitivity, specificity, positive predictive (PPV)...

10.1111/bju.16720 article EN BJU International 2025-04-04

Giant cell arteritis (GCA) is a systemic vasculitis of elderly individuals associated with significant morbidity, including blindness, stroke, and myocardial infarction. Previous studies have investigated whether GCA increased mortality, conflicting results. The objective this study to determine GCA, mortality. Forty-four cases were identified from the University Utah Health Sciences Center, major tertiary care center for Intermountain West. Population Database, unique biomedical information...

10.1093/gerona/gln030 article EN The Journals of Gerontology Series A 2009-02-04

Purpose: To determine the diagnostic value of individual image post-processing techniques in a series patients who underwent extratemporal operations for histologically proven, MRI-negative focal cortical dysplasia (FCD). Methods: The morphometric analysis program (MAP), PET/MRI co-registration and statistical parametric mapping (SPM) PET (SPM-PET) were analyzed 33 consecutive patients. epileptogenic zone (EZ) assumed by MAP, PET/MRI, SPM-PET was compared with location FCD lesions determined...

10.3389/fneur.2018.00450 article EN cc-by Frontiers in Neurology 2018-06-14

Abstract Background Three‐dimensional reconstruction of chest computerized tomography (CT) excels in intuitively demonstrating anatomical patterns for pulmonary segmentectomy. However, current methods are labor‐intensive and rely on contrast CT. We hereby present a novel fully automated algorithm based noncontrast CT assess its performance both independently combination with surgeons. Methods A retrospective pilot study was performed. Patients between May 2020 to August who underwent...

10.1111/1759-7714.14322 article EN cc-by Thoracic Cancer 2022-02-09

We compare Prostate Health Index, Index density, and PSA density in predicting clinically significant prostate cancer MRI-guided biopsy.This is a multicenter evaluation of prospectively maintained biopsy databases at 10 urology centers. Men with targeted systematic performed without prior diagnosis were included. The additional value to MRI PI-RADS (Prostate Imaging Reporting & Data System) score was evaluated multivariable analyses, area under the curve, decision curve analyses. proportion...

10.1097/ju.0000000000003450 article EN The Journal of Urology 2023-04-10

Compare the efficacy and safety of minimally invasive open transforaminal lumbar interbody fusion (TLIF) in treatment single segmental spondylolisthesis.From 2010-01 to 2015-10, total, 167 patients with spondylolisthesis treated by TLIF were included, 79 cases (MI-TLIF) group 88 group. The peri-operative parameters operative time, estimated blood loss length postoperative hospital stay was recorded, as well complications. Visual Analogue Scale (VAS) low back pain leg pain, Oswestry...

10.21037/atm.2018.02.11 article EN Annals of Translational Medicine 2018-03-01
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