A5101877814- Urticaria and Related Conditions
- Ruminant Nutrition and Digestive Physiology
- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Cancer, Lipids, and Metabolism
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Asthma and respiratory diseases
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Research Studies
- Genetic and phenotypic traits in livestock
- Animal Nutrition and Physiology
- Lung Cancer Treatments and Mutations
- Allergic Rhinitis and Sensitization
- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
- RNA Research and Splicing
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Meat and Animal Product Quality
- Ocular Surface and Contact Lens
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
China Agricultural University
2022-2024
Zhongnan Hospital of Wuhan University
2020-2024
Wuhan University
2020-2024
AbbVie (United States)
2022-2024
Southwest Medical University
2024
Guangxi University
2023-2024
Second Xiangya Hospital of Central South University
2022-2023
Central South University
2022-2023
Sichuan Cancer Hospital
2022
Chongqing Medical University
2022
Adding radiotherapy (RT) to systemic therapy improves progression-free survival (PFS) and overall (OS) in oligometastatic non-small cell lung cancer (NSCLC). Whether these findings translate epidermal growth factor receptor (EGFR)-mutated NSCLC remains unknown. The SINDAS trial (NCT02893332) evaluated first-line tyrosine kinase inhibitor (TKI) for EGFR-mutated synchronous randomized upfront RT vs no RT; we now report the prespecified interim analysis at 68% accrual.Inclusion criteria were...
The pathogenesis of atherosclerosis is closely related to endothelial cell injury caused by lipid peroxidation-induced ferroptosis. Tanshinone IIA (TSA) protects tissues from damage. In this study, we investigated whether TSA exerts its protective effect on cells inhibiting Ferroptosis was induced in human coronary artery (HCAECs), and were treated with TSA. Morphological examination indicated that exerted a significant the HCAECs. This further confirmed LDH release death detection assays....
Indocyanine green (ICG) fluorescence imaging technology is increasingly widely used in laparoscopic hepatectomy. However, whether it can provide long-term survival benefits to patients with liver malignancies remains unclear. This study investigated the clinical effect of hepatectomy for hepatocellular carcinoma (HCC) using ICG technology. We retrospectively analyzed HCC who underwent at Zhongnan Hospital Wuhan University from January 2016 December 2020. Propensity score matching (PSM) was...
BackgroundCharacterization of upadacitinib use and switching from dupilumab to among patients with moderate-to-severe atopic dermatitis (AD) is needed.ObjectiveTo evaluate the long-term safety efficacy continuous 30 mg after 24 weeks dupilumab.MethodsAdults who completed phase 3b clinical trial oral vs injectable 300 (Heads Up) entered a 52-week open-label extension (OLE) (NCT04195698) were included. All received 30-mg during period. We report results prespecified interim OLE 16-week...
Abstract Background This study aimed to isolate the rumen-derived bacteria with ability degrade free gossypol (FG), and evaluate probiotic potential in vitro for ensuring safe utilization. Methods The strains were anaerobically isolated from fresh rumen fluid of sheep long-term fed cottonseed meal (CSM) screening agar medium containing as sole carbon source. Afterwards, strain incubated CSM was subjected determination FG degradation evaluation characteristics. Results target labeled Lact....
Centromere protein U (CENPU), a centromere-binding required for cellular mitosis, has been reported to be closely associated with carcinogenesis in multiple malignancies; however, the role of CENPU hepatocellular carcinoma (HCC) is still unclear.Herein, we investigated its biological and molecular mechanism development HCC.High expression HCC tissue was observed correlated positively poor prognosis patients.CENPU knockdown inhibited proliferation, metastasis, G1/S transition cells vivo...
Abstract Background Dysregulated ubiquitination modification occupies a pivotal role in hepatocellular carcinoma (HCC) tumorigenesis and progression. The ubiquitin aldehyde binding 1 (OTUB1) was aberrantly upregulated exhibited the pro-tumorigenic function HCC. However, underlying mechanisms responsible targets of OTUB1 remain unclear. Methods First, bioinformatics analysis, western blot immunohistochemistry staining were applied to analyze expression HCC specimens. Then, immunoprecipitation...
MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression through the endogenous RNA interference machinery. Treatments with combination of chemotherapy surgery essential for advanced-stage colorectal cancer. However, development chemoresistance is a major obstacle clinical application anticancer drugs. In this study, we report miR-203-SIK2 axis involves in regulation Taxol sensitivity colon cancer cells. MiR-203 downregulated human tumor specimens and cell lines compared...
Therapeutic targeting of advanced or metastatic non-small-cell lung cancer (NSCLC) represents a major goal clinical treatment. Polo-like kinase 1 (PLK1) is an essential mitotic in cell cycle progression and associated with oncogenesis large spectrum types, including NSCLC. Volasertib (BI 6727) potent, selective, PLK1 inhibitor that currently under phase 2 trials modest antitumor activity against solid tumors. As the combination volasertib pemetrexed does not improve efficacy for NSCLC...
Background Hepatocellular carcinoma is the third most deadly malignant tumor in world with a poor prognosis. Although immunotherapy represents promising therapeutic approach for HCC, overall response rate of HCC patients to less than 30%. Therefore, it great significance explore prognostic factors and investigate associated immune microenvironment features. Methods By analyzing RNA-seq data TCGA-LIHC cohort, set cuproptosis related genes was extracted via correlation analysis as...
The inflammatory response induced by fine particulate matter (PM2.5), a common class of air pollutants, is an important trigger for the development pulmonary fibrosis. However, specific mechanisms responsible this phenomenon are yet to be fully understood. To investigate behind onset and progression lung fibrosis owing PM2.5 exposure, both rats human bronchial epithelial cells were subjected varying concentrations PM2.5. involvement PPARG/HMGB1/NLRP3 signaling pathway in developing caused...
Abstract Despite of advances in treatment options, hepatocellular carcinoma (HCC) remains nearly incurable and has been recognized as the third leading cause cancer-related deaths worldwide. As a deubiquitinating enzyme, antitumor effect ubiquitin-specific peptidase 53 (USP53) demonstrated on few malignancies. In this study, we investigated potential role USP53 HCC. The results showed that was downregulated HCC tissues well cell lines using both silico data patient samples. Furthermore,...
Recently, near-infrared (NIR) excitation has been suggested for PDT improvement and therapy of cancer.
Cysteamine (CS) is a vital antioxidant product and nutritional regulator that improves the productive performance of animals. A 2 × 4 factorial in vitro experiment was performed to determine effect CS supplementation levels 0, 20, 40, 60 mg/g, based on substrate weight, ruminal fermentation, capacity, microorganisms high-forage (HF, forage:corn meal = 7:3) Statistical Analysis System Institute. After 48 h incubation, dry matter disappearance gas production LF group were higher when compared...
The aim of this study was to investigate whether guanidine acetic acid (GAA) yields a response in rapid-growing lambs depending on forage type. In study, seventy-two small-tailed Han (initial body weights = 12 ± 1.6 kg) were used 120-d feeding experiment after 7-d adaptation period. A 2 × 3 factorial experimental design applied the lambs, which fed total mixed ration with two types (OH: oaten hay; OHWS: hay plus wheat silage) and three forms additional GAA (GAA: 0 g/kg; UGAA: Uncoated GAA, 1...
Upadacitinib, an oral selective Janus kinase (JAK) inhibitor, is used to treat moderate-to-severe atopic dermatitis (AD). Acne the most common treatment-emergent adverse event in patients with AD treated upadacitinib. In this post hoc analysis, we describe acne events Japanese who received upadacitinib during Rising Up study.In phase 3, double-blind, 3-year trial evaluating safety and efficacy of 15 mg or 30 AD, were randomized 1:1:1 receive mg, placebo for up 16 weeks. At week 16,...
Guanidine acetic acid (GAA) is increasingly considered as a nutritional growth promoter in monogastric animals. Whether or not such response would exist rapid-growing lambs unclear yet. The objective of this study was to investigate whether dietary supplementation with uncoated GAA (UGAA) and coated (CGAA) could alter performance, nutrient digestion, serum metabolites, antioxidant capacity lambs. Seventy-two small-tailed Han initially weighed 12 ± 1.6 kg were randomly allocated into six...
Background: The liver's regenerative capacity allows it to repair itself after injury. Extracellular vesicles and particles (EVPs) in the interstitial space are crucial for signal transduction, metabolism, immune regulation. Understanding role mechanism of liver-derived EVPs regeneration is significant, particularly partial hepatectomy, where mechanisms remain unclear. Methods: A 70% hepatectomy model was established mice, were isolated characterized using electron microscopy,...