A5016691634- MicroRNA in disease regulation
- RNA modifications and cancer
- Extracellular vesicles in disease
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Liver Disease and Transplantation
- Cancer, Hypoxia, and Metabolism
Zhongnan Hospital of Wuhan University
2022-2025
Wuhan University
2022-2025
Abstract Background Hepatocellular carcinoma (HCC) is one of the most prevalent cancers in world, with a high likelihood metastasis and dismal prognosis. The reprogramming glucose metabolism critical development HCC. Warburg effect has recently been confirmed to occur variety cancers, including However, little known about molecular biological mechanisms underlying HCC cells. In this study, we sought better understand how methyltransferase 5, N6‐adenosine (METTL5) controls effect. Methods...
ABSTRACT Background Early‐stage pancreatic ductal adenocarcinoma (PDAC) is frequently misdiagnosed, contributing to its high mortality rate. Exosomal microRNAs (miRNAs) have emerged as potential biomarkers for the early detection of PDAC. Aims This study aimed evaluate feasibility using exosomal miRNAs from PDAC tissues and serum prognosis. Materials & Methods Exosomes were isolated healthy individuals patients via tissue samples, then identified by analyzing their particle size protein...
Background: The liver's regenerative capacity allows it to repair itself after injury. Extracellular vesicles and particles (EVPs) in the interstitial space are crucial for signal transduction, metabolism, immune regulation. Understanding role mechanism of liver-derived EVPs regeneration is significant, particularly partial hepatectomy, where mechanisms remain unclear. Methods: A 70% hepatectomy model was established mice, were isolated characterized using electron microscopy,...
Abstract Cholangiocarcinoma (CCA) is the second most common hepatobiliary cancer, and its incidence has increased significantly in recent years. CCA poor prognosis owing to limited diagnosis treatment options. The tumor immune microenvironment (TIME), which comprises cells, cytokines, chemokines, plays a significant role cancer progression, evasion of surveillance, therapeutic responses. Immunotherapeutic strategies targeting TIME offer potential for recognition eradication CCA. This review...