Chemotherapy drug resistance frequently happens in more than 50% of bladder cancer patients and is the major obstacle for therapy. Recent studies have shown that long noncoding RNA (lncRNA) involved development chemoresistance. In this study, we reported hypoxia inducible factor 1α-antisense 2 (HIF1A-AS2), as a subtype-specific lncRNA, upregulated cells tissue after cisplatin (Cis) treatment. The induction HIF1A-AS2 rendered to Cis-induced apoptosis. Silencing Cis-resistant was re-sensitized...

Pneumonia is a lower respiratory disease caused by pathogens or other factors. This study aimed to explore the roles and mechanism of long noncoding RNA HAGLROS in lipopolysaccharides (LPS)-induced inflammatory injury pneumonia. The expression serum patients with acute stage pneumonia was detected. To induce pulmonary injury, WI-38 human lung fibroblasts were stimulated (LPS). expressions LPS-treated cells effects knockdown on viability, apoptosis, autophagy LPS-induced Moreover, regulatory...

Metformin, a common therapeutics for type 2 diabetics, was recently demonstrated to possess antitumor activity in various cancer types.However, its therapy effect renal cell carcinoma (RCC) still remains controversial.In this study, we found that metformin treatment RCC cells lead activation of AMPK, which suppressed the proliferation under normal condition, but enhanced glucose deprivation (GD) condition.Depletion AMPK by siRNA abolished MF GD condition.Mechanistic investigations revealed...

Development of hybrid nanozymes with high catalytic efficiency is critical importance for enzyme mimics in biological fields. Herein, we reported a polydopamine (PDA) surface modification-assisted pyrolysis strategy preparing CoO nanoparticles/N-doped carbon sheets/reduced graphene oxide composites (CoO/N-CS-rGO). In this strategy, PDA abundant amines and imines could serve as an eco-friendly N-contained precursor connecting agent between GO matrix CoO. Due to the superior conductivity...

MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression through the endogenous RNA interference machinery. Treatments with combination of chemotherapy surgery essential for advanced-stage colorectal cancer. However, development chemoresistance is a major obstacle clinical application anticancer drugs. In this study, we report miR-203-SIK2 axis involves in regulation Taxol sensitivity colon cancer cells. MiR-203 downregulated human tumor specimens and cell lines compared...

Papillary thyroid carcinoma (PTC) is a differentiated type of malignancy with high incidence. Long non-coding RNA (lncRNA) DUXAP8 has been reported to participate in the proliferation, migration, and invasion several cancer types. However, its association PTC not yet reported. The current study aimed investigate role revealed underlying mechanisms. expression was knocked down two cell lines effects on biological behavior were examined by counting kit-8 (CCK-8), wound healing, transwell...

In this study, we aimed to investigate how MORC family CW-type zinc finger 2 (MORC2) affects tumor progression of lung cancer.The MORC2 level was analyzed by real-time RT-PCR and immunohistochemistry (IHC) in normal control tissues cancers. LL/2 cells overexpressing were used study expression influences cancer progression. The effects on cell viability, migration invasion assessed MTT assay, Western blotting, transwell assays, respectively. Afterwards, the activation Wnt/β-catenin pathway...

Abstract Background: Long non-coding RNA taurine up-regulated gene 1 (TUG1) was reportedly involved in initiation and development of several cancers. However, its function molecular mechanisms multiple myeloma (MM) are still unclear. The present study aimed to determine the expression status, biological function, potential TUG1 progression MM. Materials methods: levels were examined MM samples cell lines by real-time quantitative PCR. effects on cells proliferation apoptosis assessed using...

Abstract Rupture of atherosclerotic plaques constitutes the major cause thrombosis and acute ischemic coronary syndrome. Bone marrow‐derived mesenchymal stem cells microvesicles (BMSCs‐MVs) are reported to promote angiogenesis. This study investigated role BMSCs‐MVs in stabilizing plaques. mice were isolated identified. The mouse model atherosclerosis was established, injected with via tail vein. macrophage high glucose oxidative damage established then incubated BMSCs‐MVs. Nod‐like receptor...

Abstract Female gender has been identified as one of the risk factors closely linked to perioperative anxiety and a lower level satisfaction. A successful preoperative anesthesia education may improve such negative outcomes. The aim this study was investigate whether via an Anesthesia Service Platform (ASP) could reduce levels in female patients scheduled for laparoscopic cholecystectomy under general anesthesia, accelerate rehabilitation. total 222 elective were randomly assigned control...

Supramolecular nanoparticles with enhanced aggregation-induced emission are prepared by taking advantage of pillar[5]arene-based host–guest complexation, and sophisticated nanocarriers for imaging-guided drug delivery.

There is evidence that angiotensin II (Ang II) may impair the functions of endothelial progenitor cells (EPCs). It was revealed DJ-1 could resist oxidative stress. In this study, we investigated whether protect EPCs against Ang II-induced cell damage. The proliferation and migration were strongly reduced in group increased by overexpression DJ-1. Western blotting indicated expression senescence marker β-galactosidase decreased adhesion molecules (ICAM-1, VCAM-1) induced reversed after...

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). retracted at the request of Editor-in-Chief. Given comments Dr Elisabeth Bik regarding this “… Western blot bands in all 400+ papers are very regularly spaced and have a smooth appearance shape dumbbell or tadpole, without any usual smudges stains. All placed similar looking backgrounds, suggesting they were copy/pasted from other...

Histone H4 acetylation at lysine 12 (H4K12ac) has been reported to be associated with the poor prognosis of pancreatic cancer. The study intends whether H4K12ac participates in regulating carcinogenic effect Ras-ERK1/2 on osteosarcoma (OS). plasmids pEGFP-N1, pEGFP-RasWT and pEGFP-K-RasG12V/T35S were transfected into MG-63 cells, protein levels ERK1/2 analyzed by Western blot. Effects cell proliferation migration cells tested 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2Htetrazolium bromide...

Scope Alzheimer's disease (AD) has been a challenge and hotspot in the field of neuroscience research due to high morbidity. As we all know, walnut kernel (WK) ingestion linked benefits brain health function improving memory. This study follows AD model induced by scopolamine reveal active fractions substances treatment AD. Methods results The histopathological analysis tissue biochemistry assay are revealed WK, this result determines that organic acids have significant therapeutic effect on...

Abstract Osteosarcoma (OS) is a conversant malignant bone tumor, commonly occurs in children and adolescents. Nimotuzuma an epidermal growth factor receptor (EGRF) monoclonal antibody agent, which has been exploited varied solid tumors. Nevertheless, the functions of OS remain blurry. We attempted to disclose impacts on cells proliferation apoptosis. MG‐63 U2OS were stimulated with disparate doses Nimotuzuma. Then, cell viability, cycle, apoptosis appraised through executing CCK‐8 flow...

To investigate the effect of gastrointestinal function on incidence ventilator-associated pneumonia (VAP) in critically ill patients.From August 2012 to June 2016, 160 patients ICU (Intensive Care Unit) our hospital were selected as research group; divided equally into an observation group and a control group, 80 each based random draw envelope principle. The was given nasogastric tube for gastric feeding, dual lumen enteral device feeding; two groups' nutrition time 7d; any changes patient...