A5073269968- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- Cancer-related Molecular Pathways
- CAR-T cell therapy research
- Cancer-related gene regulation
- DNA Repair Mechanisms
- Genetic factors in colorectal cancer
- Prostate Cancer Treatment and Research
- Wnt/β-catenin signaling in development and cancer
- RNA modifications and cancer
- Spinal Cord Injury Research
- Cancer Genomics and Diagnostics
- Connective tissue disorders research
- Signaling Pathways in Disease
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Plasmonic and Surface Plasmon Research
- Cancer Research and Treatments
- Ubiquitin and proteasome pathways
- BRCA gene mutations in cancer
- Cancer Cells and Metastasis
- Protease and Inhibitor Mechanisms
- Melanoma and MAPK Pathways
- Cancer, Hypoxia, and Metabolism
- Metamaterials and Metasurfaces Applications
Jilin University
2016-2025
Union Hospital
2018-2025
Union Hospital
2016-2024
Qiannan Normal College For Nationalities
2017-2023
Guangxi University of Science and Technology
2021-2022
Computer Algorithms for Medicine
2020
Louisiana State University Health Sciences Center New Orleans
2008-2018
Sun Yat-sen University
2016-2017
Jilin Medical University
2015
Institut Gustave Roussy
2014
Earlier studies of invasive breast tumors have shown that 60–80% are aneuploid and ≈80% exhibit amplified centrosomes. In this study, we investigated the relationship centrosome amplification with aneuploidy, chromosomal instability, p53 mutation, loss differentiation in human tumors. Twenty seven normal tissues were analyzed by fluorescence situ hybridization centromeric probes to chromosomes 3, 7, 17. We these for both aneuploidy unstable karyotypes as determined instability. The results...
The excess production of reactive oxygen species (ROS) after traumatic spinal cord injury (TSCI) has been identified as a leading cause secondary injury, which can significantly exacerbate acute damage in the injured cord. Thus, scavenging ROS emerged an effective route to ameliorate injury.Selenium-doped carbon quantum dots (Se-CQDs) with ability scavenge were prepared and used for efficiently ameliorating TSCI.Water-soluble Se-CQDs easily synthesized via hydrothermal treatment...
The microenvironment after traumatic spinal cord injury (SCI) involves complex pathological processes, including elevated oxidative stress, accumulated reactive aldehydes from lipid peroxidation, excessive immune cell infiltration, etc. Unfortunately, most of current neuroprotection therapies cannot cope with the intricate pathophysiology SCI, leading to scant treatment efficacies. Here, we developed a facile in situ reaction-induced self-assembly method prepare aldehyde-scavenging...
The human acid ceramidase gene, that causes Farber disease, is located in 8p22, a region frequently altered several cancers, including prostate cancer. Acid catalyzes the hydrolysis of ceramide, potent lipid second messenger molecule promotes apoptosis and inhibits cellular proliferation. It not known whether this or its expression, Here, we report structural organization expression tissues, identification single nucleotide polymorphisms. No cancer-related mutations were found gene panel...
The mitochondrial transcription factor A (TFAM) is required for DNA (mtDNA) replication and transcription. Disruption of TFAM results in heart failure premature aging mice. But very little known about the role cancer development. Here, we report identification frequent frameshift mutations coding mononucleotide repeat sporadic colorectal (CRC) cell lines primary tumors with microsatellite instability (MSI), but not stable (MSS) CRC tumors. presence truncating mutation, cells MSI, reduced...
Androgen signaling through androgen receptor (AR) is critical for prostate tumorigenesis. Given that AR-mediated gene regulation enhanced by AR coregulators, inactivation of those coregulators emerging as a promising therapy cancer (PCa). Here, we show the N -acetyltransferase arrest-defect 1 protein (ARD1) functions unique regulator in PCa cells. ARD1 up-regulated human cell lines and primary tumor biopsies. The expression was augmented treatment with synthetic (R1881) unless deficient or...
Disulfide-containing nanoparticles are promising vehicles for anticancer drug delivery. However, the preparation of disulfide-containing usually relies on complex synthetic procedures. In present work, a PEGylated poly(α-lipoic acid) (mPEG-PαLA) copolymer was facilely synthesized and used pH reduction dual responsive Poly(α-lipoic prepared by thermal polymerization α-lipoic acid without any catalyst or solvent then conjugated with methoxy poly(ethylene glycol) to form mPEG-PαLA copolymer....
The Marfan database is a software that contains routines for the analysis of mutations identified in FBN1 gene encodes fibrillin-1. Mutations this are associated not only with syndrome but also spectrum overlapping disorders. third version 137 entries. has been modified to accommodate four new and now accessible on World Wide Web at http://www.umd.necker.fr
Background Expression level of many genes shows abundant natural variation in human populations. The variations gene expression are believed to contribute phenotypic differences. Emerging evidence has shown that microRNAs (miRNAs) one the key regulators expression. However, past studies have focused on miRNA target and used loss- or gain-of-function approach may not reflect association between mRNAs. Methodology/Principal Findings To examine regulatory effect global under endogenous...
Abstract Aberrant activation of the Wnt/β-catenin signaling pathway is a critical event in advanced prostate cancer, but genetic alterations that activate Wnt many other cancers are rarely observed cancer. Other molecular mechanisms regulate cancer remain to be identified. Here, it demonstrated KIF3a, subunit kinesin-II motor protein, functions as an agonist KIF3a upregulated majority human cell lines and primary tumor biopsies. The expression levels correlate with higher Gleason score,...
Microenvironments of various solid tumors are characterized by hypoxia. Herein, we report a novel nanoparticle that can selectively release loaded drugs in hypoxic environments. The was prepared using hypoxia-responsive amphiphilic polymer aqueous media. synthesized conjugating hydrophobic small molecule, 4-nitrobenzyl (3-azidopropyl) carbamate, to the side chains an mPEG-PPLG copolymer. Doxorubicin (DOX) could be into nanoparticles with high efficiency 97.8%. generated drug-loaded micellar...