A5102959020- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammasome and immune disorders
- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- RNA modifications and cancer
- Axon Guidance and Neuronal Signaling
- Lung Cancer Treatments and Mutations
- MicroRNA in disease regulation
- NF-κB Signaling Pathways
- Adenosine and Purinergic Signaling
- Medical Imaging and Pathology Studies
- Nerve injury and regeneration
- Extracellular vesicles in disease
- Bone Metabolism and Diseases
- Toxic Organic Pollutants Impact
- Epigenetics and DNA Methylation
- Complement system in diseases
- Thyroid Cancer Diagnosis and Treatment
- Virus-based gene therapy research
- Coenzyme Q10 studies and effects
- Acute Kidney Injury Research
- RNA and protein synthesis mechanisms
- Pain Mechanisms and Treatments
Jilin University
2014-2024
Third Affiliated Hospital of Sun Yat-sen University
2022-2024
Sun Yat-sen University
2022-2024
Qilu Hospital of Shandong University
2016-2024
Children's Hospital of Chongqing Medical University
2024
Union Hospital
2024
University of Jinan
2024
Shanghai University of Traditional Chinese Medicine
2024
Tianjin Tianhe Hospital
2024
Tianjin Medical University
2021-2024
Cognitive impairment has been associated with an age-related decline in adult hippocampal neurogenesis (AHN). The molecular basis of declining the aging hippocampus remains to be elucidated. Here, we show that pleiotrophin (PTN) expression is decreased neural stem and progenitor cells (NSPCs). Mice lacking PTN exhibit impaired AHN accompanied by poor learning memory. Mechanistically, find engages protein tyrosine phosphatase receptor type Z1 (PTPRZ1) promote NSPC proliferation...
Cognitive dysfunction is a feature in multiple sclerosis (MS), chronic inflammatory demyelinating disorder. A notable aspect of MS brains hippocampal demyelination, which closely associated with cognitive decline. However, the mechanisms underlying this phenomenon remain unclear. Chitinase-3-like (CHI3L1), secreted by activated astrocytes, has been identified as biomarker for progression. Our study investigates CHI3L1's function within hippocampus and demonstrates correlation between CHI3L1...
Abstract Background Human discs large-associated protein 5 (DLGAP5) is reported to play a pivotal role in regulating the cell cycle and implicate tumorigenesis progression of various cancers. Our current research endeavored explore prognostic value, immune implication, biological function targeting strategy DLGAP5 LUAD through approaches including bioinformatics, network pharmacology analysis experimental study. Methods Multiple databases, TCGA, GEO, CPTAC Protein Atlas, were utilized...
Chitinase-3–like protein 1 (CHI3L1) is primarily secreted by activated astrocytes in the brain and known as a reliable biomarker for inflammatory central nervous system (CNS) conditions such neurodegeneration autoimmune disorders like neuromyelitis optica (NMO). NMO an astrocyte disease caused autoantibodies targeting astroglial aquaporin 4 (AQP4) leads to vision loss, motor deficits, cognitive decline. In this study examining CHI3L1’s biological function neuroinflammation, we found that...
Distant metastasis (DM) is a rare event and has negative effect on the prognosis for papillary thyroid carcinoma (PTC). The relationship between cervical lymph node DM complicated unclear. This study aimed to evaluate impact of N stage subclassification different distant sites based age stratification, especially patients with microcarcinoma.
Abstract Neuromyelitis optica (NMO) is a severe autoimmune inflammatory disease of the central nervous system that affects motor function and causes relapsing disability. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have been used extensively in treatment various diseases, due to their potent regulatory roles can mitigate inflammation repair damaged tissues. However, use NMO currently limited, mechanism underlying beneficial effects hUC-MSCs on remains unclear. In this...
Proper activation of Toll-like receptor (TLR)-mediated signaling and production proinflammatory cytokines are critical for the initiation innate immunity, while specific mechanism maintaining inflammatory homeostasis remains mostly unknown. Here, we show that Ets2 is upregulated following LPS VSV stimulation. knockdown or knockout leads to increased IL-6, TNF-α, IFN-β in macrophages. Consistently, Ets2-deficient mice exacerbated cytokine more susceptible CLP-induced sepsis. Mechanistically,...
Abstract Rupture of atherosclerotic plaques constitutes the major cause thrombosis and acute ischemic coronary syndrome. Bone marrow‐derived mesenchymal stem cells microvesicles (BMSCs‐MVs) are reported to promote angiogenesis. This study investigated role BMSCs‐MVs in stabilizing plaques. mice were isolated identified. The mouse model atherosclerosis was established, injected with via tail vein. macrophage high glucose oxidative damage established then incubated BMSCs‐MVs. Nod‐like receptor...
Abstract Neuromyelitis optica spectrum disorder (NMOSD) is a severe inflammatory autoimmune disease of the central nervous system that manifested as secondary myelin loss. Oligodendrocyte progenitor cells (OPCs) are principal source myelinating oligodendrocytes (OLs) and abundant in demyelinated regions NMOSD patients, thus possibly representing cellular target for pharmacological intervention. To explore therapeutic compounds enhance myelination due to endogenous OPCs, we screened candidate...
Osteoporosis is characterized by systemic microarchitecture impairment and bone loss, which ultimately lead to fragility fractures. This disease most common in older people, especially postmenopausal women. Cancellous affected osteoporosis earlier than cortical bone, DNA methylation microarray analysis of the hip cancellous patients with osteoarthritis revealed differential methylation. In view important role development, we examined genome‐wide profiles from versus healthy women using...
Tissue specificity of gene expression sheds light on the tissue-selective manifestation hereditary disease despite same DNA across all tissues. The evolutionary path such tissue provides essential information about tissue-specific function genes and validity animal models. With recent improvements sequencing technology, more large-scale transcriptomics studies have been conducted among different species multiple In this study, we exploit existing resources humans, cynomolgus macaques, rats,...
Cyclooxygenase-2 (COX-2) is an enzyme that plays a pivotal role in peripheral inflammation and pain via the prostaglandin pathway. In central nervous system (CNS), COX-2 implicated neurodegenerative psychiatric disorders as potential therapeutic target biomarker. However, clinical studies with have yielded inconsistent results, partly due to limited mechanistic understanding of how activity relates CNS pathology. Therefore, developing positron emission tomography (PET) radiotracers for human...
Mammalian mitochondrial ribosomal proteins are a group of protein factors encoded by nuclear genes, responsible for the synthesis in mitochondria.As member proteins, MRPL42 (mitochondrial L42) belongs to 28S and 39S subunits.The current literature showed that its role lung adenocarcinoma (LUAD) was not clear.We found highly expressed early-stage LUAD tissues cell lines, remarkably related prognosis patients.Knockdown could reduce proliferation colonization, promote cycle arrest G1/S phase,...
To enable long-term survival, mammalian adult neurons exhibit unique apoptosis competence. Questions remain as to whether and how globally reprogram the expression of apoptotic genes during development. We systematically examined in vivo 1923 apoptosis-related associated histone modifications at eight developmental ages mouse brains. Most displayed consistent temporal patterns across forebrain, midbrain, hindbrain, suggesting ubiquitous robust reprogramming. Although both anti- pro-apoptotic...