A5019529432- Mesenchymal stem cell research
- Neurogenesis and neuroplasticity mechanisms
- Neonatal and fetal brain pathology
- Hematopoietic Stem Cell Transplantation
- Neonatal Respiratory Health Research
- Anesthesia and Neurotoxicity Research
- Pluripotent Stem Cells Research
- MicroRNA in disease regulation
- Acute Myeloid Leukemia Research
- Cerebral Palsy and Movement Disorders
- Neurogenetic and Muscular Disorders Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- Transplantation: Methods and Outcomes
- Metabolism and Genetic Disorders
- Nerve injury and regeneration
- Circular RNAs in diseases
- Cytomegalovirus and herpesvirus research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological Disease Mechanisms and Treatments
- Pregnancy and preeclampsia studies
- Lysosomal Storage Disorders Research
- Immune Cell Function and Interaction
- Neonatal Health and Biochemistry
- Birth, Development, and Health
Chinese PLA General Hospital
2019-2025
Fourth People's Hospital of Liaocheng
2024
Shandong First Medical University
2024
PLA Navy General Hospital
2011-2022
Guangxi Medical University
2020-2022
Southern Medical University
2020-2021
Third Affiliated Hospital of Southern Medical University
2018
Pediatrics and Genetics
2017
Alibaba Group (China)
2015
In-Q-Tel
2015
Cerebral palsy (CP) is a chronic nervous system disease that severely damages the physical and developmental health of children. Traditional treatment brings about only improvement mild to moderate CP, but severe CP still lacks effective interventions. To explore safety efficacy using neural progenitor cells (NPCs) treat in children, we performed NPC transplantation 45 patients with by injecting NPCs derived from aborted fetal tissue into lateral ventricle. Gross motor function measures...
We investigated the efficacy of allogeneic hematopoietic stem cell transplantation (alloHSCT) in pediatric patients with mucopolysaccharidosis (MPS). A retrospective analysis data from 34 cases MPS China Children Transplant Group, treated between December 2004 and September 2015, was conducted. Among cases, 12 were type I, II, 4 IV, VI, 2 an unknown type. The median age at 3.75 years (range, 1 to 7 years); follow-up time 14 months 119 months). Eleven underwent unrelated cord blood 23...
The secretome of mesenchymal stem cell (MSC) offers a series immunoregulatory properties and is regarded as an effective method mitigating secondary neuroinflammation induced by traumatic brain injury (TBI). adipose-derived MSCs (ASC-ST) was collected under hypoxia conditions. Proteomics data were analyzed liquid chromatography–tandem mass spectrometry (LC-MS/MS), concentrations major components tested. After the TBI caused electric cortical contusion impactor, rats injected ASC-ST through...
Cell therapy has been shown to be a key clinical therapeutic option for central nervous system diseases or damage. Standardization of cell procedures is an important task professional associations devoted therapy. The Chinese Branch the International Association Neurorestoratology (IANR) completed first set guidelines governing application neurorestoration in 2011. IANR and (CANR) collaborated propose current version "Clinical Therapy Guidelines Neurorestoration (IANR/CANR 2017)". council...
In premature newborn infants, preterm white matter injury (PWMI) causes motor and cognitive disabilities. Accumulating evidence suggests that PWMI may result from defected differentiation of oligodendrocyte precursor cells (OPCs) impaired maturation oligodendrocytes. However, the underlying mechanisms remain unclear. Using RNAscope, we analyzed expression level RNA-binding protein LIN28A in individual OPCs. Knockout one or both alleles Lin28a OPCs was achieved by administrating tamoxifen to...
Summary Haploidentical haematopoietic stem cell transplantation (haplo‐ HSCT ) used to be a third‐line treatment option for childhood severe aplastic anaemia ( SAA ). We conducted this retrospective study of 36 children (38 transplants) who received haplo‐ from human leucocyte antigen HLA )‐mismatched related donors between July 2002 and November 2013 at five centres in China, including 17 cases that were 5/6 matched (Group 1) 21 4/6 or 3/6 2). Although patients Group 2 had higher incidence...
The role and potential efficacy of antithymocyte globulin (ATG) in patients receiving cord blood transplantation (CBT) remain controversial. We retrospectively evaluated the effect ATG on patient outcomes 207 children with high-risk or advanced hematological malignancies at 8 child disease centers China. cumulative incidence platelet recovery day 100 was significantly lower cohort compared non-ATG (77.3% versus 89.8%) (P = .046). There no significant difference grade II to IV acute chronic...
Abstract Human neural stem cells (NSCs) are self-renewing, multipotent of the central nervous system (CNS). They characterized by their ability to differentiate into a range cells, including oligodendrocytes (OLs), neurons, and astrocytes, depending on exogenous stimuli. An efficient easy directional differentiation method was developed for obtaining large quantities high-quality human OL progenitor (OPCs) OLs from NSCs. RNA sequencing, immunofluorescence staining, flow cytometry, western...
Oligovascular niche mediates interactions between cerebral endothelial cells and oligodendrocyte precursor (OPCs). Disruption of OPC-endothelium trophic coupling may aggravate the progress white matter injury (WMI) because could not provide sufficient support under diseased conditions. Endothelial progenitor (EPCs) have been reported to ameliorate WMI in adult brain by boosting oligovascular remodeling. It is necessary clarify role conditioned medium from hypoxic preconditioned EPCs...
Background: Preterm white matter injury (PWMI) is a common brain and leading cause of life-long neurological deficits in premature infants; however, no effective treatment available yet. This study aimed to investigate the fate effectiveness transplanted human oligodendrocyte progenitor cells (hOPCs) rat model PWMI. Methods: Hypoxia-ischemia was induced rats at postnatal day 3, hOPCs (6 × 105 cells/5 μL) were intracerebroventricularly 7. Neurobehavior assessed 12 weeks post-transplant using...
The purpose of this study was to investigate the clinical efficacy neural stem/progenitor cell (NS/PC) transplantation treat severe cortical visual impairment (CVI), a sequela neonatal brain injury. Fifty-two patients with cerebral injury and CVI were randomly divided into two groups: treatment group (n = 25, median age 18 months) control 27, 19.5 months). received intracerebroventricular human NS/PCs rehabilitation training. only. function assessed by Holt's method at various time points...
Abstract Background The dual inhibitors of receptor interacting protein kinase-1 and -3 (RIP1 RIP3) play an important role in cell death processes inflammatory responses. White matter injury (WMI), a leading cause neurodevelopmental disabilities preterm infants, which is characterized by extensive myelination disturbances demyelination. Neuroinflammation, leads to the loss differentiation-inhibition oligodendrocyte precursor cells (OPCs), represents major barrier myelin repair. Whether novel...
Stem cell administration via the intranasal route has shown promise as a new therapy for hypoxic-ischemic encephalopathy (HIE). In this study, we aimed to improve delivery of stem cells brain.Human neural (hNSCs) were identified using immunofluorescence, morphological, and flow cytometry assays before transplantation, migration capacity was examined transwell assay. Cerebral hypoxia-ischemia (HI) induced in 7-day-old rats, followed by transplantation CM-Dil-labeled hNSCs. We various...
Adipose-derived mesenchymal stem cell (ADMSC) therapy can promote recovery from cerebral ischemia; however, more information regarding appropriate sources of ADMSCs is required. This study was aimed at analyzing the immunogenicity rat by comparing immunological effects intraparenchymal administration allogeneic (allo-ADMSCs) and autologous (auto-ADMSCs) after acute phase middle artery occlusion (MCAO) in rats.Allo- or auto-ADMSCs rats (1 × 106 cells) were transplanted into Lewis 8 days post...
A total of 24 children with cerebral palsy were enrolled in this study and underwent ultrasound guided transplantation neural stem cells through the lateral ventricle. Neural (3.8 × 10(6)-7.3 10(7)) injected into ventricles. Mild injury ventricular blood vessels occurred only two cases (8.3%). Seven (29.2%) experienced a fever. Clinical manifestations improved to varying degrees eight (28.0%) within 3 months after transplantation. Patient condition did not worsen, no patient severe adverse reactions.
β-Thalassemia major (β-TM) has become a public health problem in mainland China. Hematopoietic stem cell transplantation (HSCT) remained the only cure for β-TM China since 1998. This multicenter retrospective study provides comprehensive review of outcomes 50 pediatric patients with who received HSCT between 1998 and 2009 at five centers Both related (n = 35) unrelated donors 15) complete human leukocyte antigen matches were included. The sources included bone marrow (BM), peripheral blood...
Abstract The success of treating a wide variety pediatric diseases with HSCT , hematologic malignancies in particular, has resulted an increased number long‐term survivors. This study is the first large‐scale, multicentre report that describes evolution s C hina during period 1998–2012. Of all 1052 patients, 266 cases were treated autologous HSC and 786 used allogeneic s. disease indications for mainly included leukemias, lymphoma, solid tumors, non‐malignant disorders. total s, especially...
Abstract In a multicenter study, we have conducted retrospective study on 73 pediatric AML patients who were primary refractory or in greater than CR 1 and investigated MSD (or MMSD ) (n = 20), URD 23), UCB 30) HCT between January 1998 October 2009. The median day to neutrophil engraftment was similar all groups. platelet longer the group. number of HLA mismatch higher group (p 0.034); however, cumulative incidence grade III–IV aGVHD not different among groups 0.125); furthermore, cGVHD...