A5024604872- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Polyomavirus and related diseases
- Acute Lymphoblastic Leukemia research
- Cytomegalovirus and herpesvirus research
- Platelet Disorders and Treatments
- Hemophilia Treatment and Research
- COVID-19 Clinical Research Studies
- Transplantation: Methods and Outcomes
- Mesenchymal stem cell research
- Blood groups and transfusion
- Chronic Myeloid Leukemia Treatments
- Neutropenia and Cancer Infections
- Retinoids in leukemia and cellular processes
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Childhood Cancer Survivors' Quality of Life
- Chronic Lymphocytic Leukemia Research
- Multiple Myeloma Research and Treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Histone Deacetylase Inhibitors Research
- Blood Coagulation and Thrombosis Mechanisms
- Glioma Diagnosis and Treatment
- Herpesvirus Infections and Treatments
University of Science and Technology of China
2018-2025
Duke Kunshan University
2021-2025
Anhui Provincial Hospital
2015-2024
Anhui Medical University
2012-2023
Wannan Medical College
2021-2023
University of Hong Kong
2021
First Affiliated Hospital of Henan University of Science and Technology
2020
Shandong University
2013
Key Points We report the first case of coronavirus disease 2019 (COVID-19) in a multiple myeloma patient successfully treated with tocilizumab. Although tocilizumab was effective treatment COVID-19 this case, randomized controlled trials are needed.
Coronavirus disease (COVID-19), caused by a novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly developed into pandemic since it was first reported in December 2019. Nucleic acid testing is the standard method for diagnosis of viral infections. However, this reportedly low positivity rate. To increase sensitivity COVID-19 diagnoses, we an IgM-IgG combined assay and tested patients with suspected SARS-CoV-2 infection. In total, 56 were enrolled...
The induction of inflammation and cytokine storm was proposed to play a critical role in COVID-19. This study is aimed at investigating the relationship between glucose metabolism inflammatory state inpatients with 71 COVID-19 were classified into nondiabetes mellitus (NDM) group, impaired fasting (IFG) diabetes (DM) group. average hospitalization days significantly shorter DM patients when compared IFG group NDM CD4+ T cell percentage higher while CD8+ cells lower than those serum levels...
Abstract Background Hetrombopag, a novel thrombopoietin receptor agonist, has been found in phase I studies to increase platelet counts and reduce bleeding risks adults with immune thrombocytopenia (ITP). This III study aimed evaluate the efficacy safety of hetrombopag ITP patients. Methods Patients who had not responded or relapsed after previous treatment were treated an initial dosage once-daily 2.5 5 mg (defined as HETROM-2.5 HETROM-5 group) matching placebo randomized, double-blind,...
Allogeneic hematopoietic stem cell transplantation (HSCT) is an effective therapy for children with high‐risk acute lymphoblastic leukemia (ALL). Human leukocyte antigen (HLA)‐haploidentical HSCT (haplo‐HSCT) or umbilical cord blood (UCBT) are both important alternative sources of cells those without HLA‐identical sibling donor unrelated matched donor. We aimed to compare the therapeutic effects single UCBT and unmanipulated haplo‐HSCT in ALL ( n = 129). Hematopoietic recovery was...
<sec><title>Background</title> Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is spreading worldwide. Measuring the prevention and control of disease has become a matter requiring urgent focus. </sec><sec><title>Objective</title> Based on 2019 (COVID-19) clinical data from Wuhan, we conducted an in-depth analysis to clarify some pathological mechanisms identify simple measures predict its severity early on. </sec><sec><title>Methods</title> A total 230 patients with...
The SARS-CoV-2 Omicron variant, since its initial detection, has rapidly spread across the globe, becoming dominant strain. It is important to study immune response of variant due remarkable ability escape majority existing neutralizing antibodies. surge in infections among most Chinese residents by end 2022 provides a unique opportunity understand system's populations with limited exposure prior variants. We tested levels IgG, IgA, and IgM specific prototype RBD (receptor-binding domain)...
The use of cosmetic Botox (BoNT/A) has become increasingly prevalent among women, even during the post-pregnancy breastfeeding period. However, there is currently a limited understanding extent enters breastmilk and its potential effect on infant. In this study, samples were acquired from five women aged between 28 45. Three sample sets ranged 1 h to year after facial treatments (64 U), whereas remaining two who never received Botox. BoNT/A concentrations in detected using standard...
<title>Abstract</title> Building on promising phase 1 pilot results demonstrating safety and efficacy of BBM-H901 (AAV-mediated FIX Padua gene therapy) in restoring factor IX activity (FIX:C) among 10 patients with haemophilia B, we conducted current studies to verify its larger Chinese B patients. A multicentre, single-arm, open-label study (phase 1/2: dose-escalation, n = 6; 3: fixed-dose, 26) a long- term study(n 10) were conducted. Eligible participants received 5×10¹² vg/kg...
It is crucial to differentiate critically ill patients exhibiting thrombocytopenia and hemolytic anemia alongside organ damage enable rapid identification of thrombotic thrombocytopenic purpura (TTP) TTP-like syndrome, which allows for targeted emergency interventions such as plasma exchange. This study retrospectively analyzed clinical data from with TTP syndrome further elucidate the potential differences between these conditions. We also established a new predictive model facilitate early...
Natural killer (NK) cell-based immunotherapy holds promise for cancer treatment; however, its efficacy remains limited, necessitating the development of alternative strategies. Here, we report that venetoclax, an FDA-approved BCL-2 inhibitor, directly activates NK cells, enhancing their cytotoxicity against acute myeloid leukemia (AML) both in vitro and vivo, likely independent inhibition. Through comprehensive approaches, including bulk single-cell RNA sequencing, avidity measurement,...
The role and potential efficacy of antithymocyte globulin (ATG) in patients receiving cord blood transplantation (CBT) remain controversial. We retrospectively evaluated the effect ATG on patient outcomes 207 children with high-risk or advanced hematological malignancies at 8 child disease centers China. cumulative incidence platelet recovery day 100 was significantly lower cohort compared non-ATG (77.3% versus 89.8%) (P = .046). There no significant difference grade II to IV acute chronic...
Reduced doses of emicizumab improve the affordability among patients in developing countries. However, relationship between variant dose selection and efficacy real world China is still unclear.
Although previous studies have demonstrated improved outcomes in umbilical cord blood transplantation (UCBT) by omitting antithymocyte globulin (ATG) the conditioning regimen, this approach has not been comparatively studied unrelated peripheral stem cell (UPBSCT). To compare risks and benefits between UCBT without ATG UPBSCT patients with acute leukemia (AL), we conducted a multicenter retrospective study of 79 who underwent (myeloablative ATG) 96 ATG). The were graft failure, neutrophil...
Abstract Background The PLASMIC score was recently published to aid in the early identification of thrombotic thrombocytopenic purpura (TTP) patients. This study aims evaluate whether this is suitable for Chinese suspected TTP patients and find utility patients' other characteristics predicting severe ADAMTS13 deficiency. Methods We retrospectively studied a cohort 38 consecutive hospitalized with TTP, test results, clinical data from September 2016 May 2018. predictive power our evaluated,...
The impact of pretransplant minimal residual disease (MRD) on outcome myeloablative cord blood transplant (CBT) for acute myeloid leukemia (AML) in complete remission (CR) has not been reported. Seventy-two AML patients were assessed MRD before CBT, and the majority (84.7%) these received single-unit CBT. All intensified conditioning with BUCY2 or TBICY plus high-dose cytarabine, graft-versus-host (GVHD) prophylaxis consisted cyclosporine mycophenolate mofetil. cumulative incidences...
This retrospective study examined risk factors for cytomegalovirus (CMV) infection after umbilical cord blood transplantation (UCBT) and the impact of CMV on patient survival.In all 176 patients, plasma DNA was negative prior to transplantation, twice a week 100 d, then once weekly additional 300 d. Preemptive antiviral therapy (ganciclovir or foscarnet) started in patients with >1,000/mL copies but no full-blown disease, discontinued upon two consecutive reports test. The survival disease...
This is the first report to present a clinical comparison of unrelated cord blood transplantation (CBT) and HLA-matched sibling allogeneic hematopoietic stem cell for patients with chronic myeloid leukemia (CML) in advanced stage (accelerated phase or blast crisis). A total 32 consecutive CML received CBT (n = 16) peripheral bone marrow (allo-PBSCT/BMT) between 2002 2011. The median day neutrophil engraftment platelet were longer group. cumulative incidence grades 1 2 acute graft-versus-host...
Hyperleukocytic acute myeloid leukemia (AML) (initial white blood cell count ≥ 100 × 109/L) is a clinical emergency often accompanied by leukostasis syndrome, tumor lysis syndrome (TLS), and disseminated intravascular coagulation (DIC), with poor prognosis. The aim of this study retrospectively analyzed the features hyperleukocytic AML, focusing on high-risk factors affecting prognosis, selection initial induction therapy, impact hematopoietic stem transplantation (HSCT) prognosis.A total...
Background: Primary immune thrombocytopenia (ITP) is defined as an acquired autoimmune disease characterized by isolated thrombocytopenia. This work to further clarify the relationship between T cell dysfunction and pathogenesis of ITP. Methods: 37 adult patients with ITP were selected classified into newly diagnosed (nITP, n = 13), persistent (pITP, 6) chronic (cITP 18). The frequency cytotoxic lymphocytes (Tc1, Tc2, Tc17) helper cells (Th1, Th2, Th17), Tregs, expression chemokine receptors...