A5102002474- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Platelet Disorders and Treatments
- Immune Cell Function and Interaction
- Blood groups and transfusion
- Phagocytosis and Immune Regulation
- Neutropenia and Cancer Infections
- Hematological disorders and diagnostics
- Lymphoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Histone Deacetylase Inhibitors Research
- Immune cells in cancer
- Monoclonal and Polyclonal Antibodies Research
- Protein Degradation and Inhibitors
- Retinoids in leukemia and cellular processes
- Erythrocyte Function and Pathophysiology
- Epigenetics and DNA Methylation
- CAR-T cell therapy research
- Glycosylation and Glycoproteins Research
- Gut microbiota and health
First Affiliated Hospital of Zhengzhou University
2016-2025
Zhengzhou Children's Hospital
2024
Fifth Affiliated Hospital of Zhengzhou University
2024
Soochow University
2024
First Affiliated Hospital of Soochow University
2024
Fujian Medical University
2024
Union Hospital
2024
Zhengzhou University
2013-2024
New York Blood Center
2024
Henan Provincial People's Hospital
2023
Approximately 8-9% of the world's population is affected by autoimmune diseases, and yet mechanism autoimmunity trigger largely understudied. Two unique cell death modalities, ferroptosis pyroptosis, provide a new perspective on mechanisms leading to development treatment strategies.Using scRNA-seq datasets, aberrant trend pyroptosis-related genes were analyzed in several representative diseases (psoriasis, atopic dermatitis, vitiligo, multiple sclerosis, systemic sclerosis-associated...
Abstract As a newly identified checkpoint, T cell immunoreceptor with immunoglobulin and tyrosine-based inhibitory motif (ITIM) domain (TIGIT) is highly expressed on CD4 + cells, CD8 natural killer (NK) regulatory cells (Tregs), tumor-infiltrating lymphocytes (TILs). TIGIT has been associated NK exhaustion in vivo individuals various cancers. It not only modulates survival but also mediates exhaustion. the primary ligand of humans, CD155 may be main target for immunotherapy due to its...
The small, heavily glycosylated protein CD24 is primarily expressed by many immune cells and highly mostly in cancer cells. As one of the most crucial biomarkers cancers, frequently solid tumors, while tumor-associated macrophages express Siglec-10 at high levels, can interact on innate to lessen inflammatory responses a variety disorders. Inhibiting inflammation brought SHP-1 and/or SHP-2 phosphatases as well cell phagocytosis macrophages, binding prevent toll-like receptor-mediated...
Knowledge of immune cell phenotypes, function, and developmental trajectory in acute myeloid leukemia (AML) microenvironment is essential for understanding mechanisms evading surveillance immunotherapy response targeting special components.Using a single-cell RNA sequencing (scRNA-seq) dataset, we analyzed the bone marrow (BM) samples from 16 AML patients 4 healthy donors, but not blasts.We observed significant difference between normal BM cells. Here, defined diversity dendritic cells (DC)...
BCMA CAR-T is highly effective for relapsed/refractory multiple myeloma(R/R-MM) and significantly improves the survival of patients. However, short remission time high relapse rate MM patients treated with remain bottlenecks that limit long-term survival. The immune microenvironment bone marrow (BM) in R/R-MM may be responsible this. present study aims to an in-depth analysis resistant mechanisms explore potential novel therapeutic targets treatment via single-cell RNA sequencing (scRNA-seq)...
In this study, we retrospectively summarized the differences of molecular gene mutations between MDS and AML patients, as well young older age groups patients. We also analyzed response newly diagnosed patients to standard DA or IA induction chemotherapy relationship outcome frequency different mutation abnormalities.NGS assay covering 43 genes was studied in 93 de novo 325 non-M3 Bone marrow samples from all underwent mutational analysis by NGS.At least one non-synonymous detected 279...
Abstract Background Hetrombopag, a novel thrombopoietin receptor agonist, has been found in phase I studies to increase platelet counts and reduce bleeding risks adults with immune thrombocytopenia (ITP). This III study aimed evaluate the efficacy safety of hetrombopag ITP patients. Methods Patients who had not responded or relapsed after previous treatment were treated an initial dosage once-daily 2.5 5 mg (defined as HETROM-2.5 HETROM-5 group) matching placebo randomized, double-blind,...
Abstract Myeloid sarcoma is a rare manifestation of acute myeloid leukemia (AML) and associated with poor overall survival (OS). The optimal treatment remains unclear. study retrospectively evaluated 118 patients who were treated at the First Affiliated Hospital Zhengzhou University from January 2010 to July 2021. All cases diagnosed by tissue biopsy. 41 underwent genetic mutation analysis. most frequent mutations KIT (16.6%), followed TET2 (14.6%), NRAS (14.6%). median time was 4 months...
The intestinal microbiome plays an important role in the development of acute graft-versus-host disease (aGVHD). However, whether microbiota can predict aGVHD has been reported only rarely. Here we conducted a prospective study 141 patients after allogeneic hematopoietic stem cell transplantation. We found lower diversity group compared with non-aGVHD at day 0 and 15 ± 1 (P = .018 .009, respectively). Diversity was negatively associated conditioning intensity .017, 0; P .045, 15) β-lactam...
We report the generation of a novel anti-LAG-3/TIGIT bispecific IgG4 antibody, ZGGS15, and evaluated its anti-tumor efficacy in mouse models as monotherapy or combination with PD-1 antibody. ZGGS15 exhibited strong affinities for human LAG-3 TIGIT, KDs 3.05 nM 2.65 nM, respectively. has EC50s 0.69 1.87 binding to TIGIT on CHO-K1 cells, competitively inhibited MHC-II (IC50 = 0.77 nM) CD155 0.24 nM). does not induce ADCC, CDC, obvious cytokine production. In vivo results showed that had better...
Isocitrate dehydrogenase 1 (IDH1) is the key enzyme that was involved in modulation of cellular metabolism, epigenetic modification and redox states homeostasis. Gain-of-function mutations decreased expression IDH1 have been demonstrated to be tightly associated with pathogenesis various myeloid malignancies characterized by ineffective erythropoiesis, such as acute leukemia (AML) myelodysplastic syndrome (MDS). However, function mechanism human erythropoiesis still remains further explored....
Although studies have reported that intestinal microbiota are associated with acute graft-versus-host disease (aGVHD), they lacked a satisfactory method for predicting aGVHD. We collected stool and blood samples at day 15 posttransplant from 150 patients two centers who underwent myeloablative conditioning allogeneic hematopoietic stem cell transplantation (allo-HSCT). Stool were detected by 16S ribosomal RNA gene sequencing; inflammatory factors T lymphocytes multiplex immunoassays flow...
Abstract This study was designed to explore whether exosomal sphingosine 1‐phosphate (S1P) from mesenchymal stem cells (MSCs) regulate the Treg/Th17 balance in aplastic anemia (AA) patients and validate underlying mechanism. To address this, exosomes human bone marrow MSCs (MSCs‐Exos) were co‐cultured with CD4 + T AA (AA cells), which transfected si‐S1PR1, si‐S1PR3, or not. The proportion of Th17 Treg evaluated by flow cytometry. levels Th17‐associated interleukin‐17 (IL‐17), Treg‐associated...
Abstract The mutational spectrum and prognostic factors of NRAS- mutated ( NRAS mut ) acute myeloid leukemia (AML) are largely unknown. We performed next-generation sequencing (NGS) in 1,149 cases de novo AML discovered 152 (13%). Of the AML, 89% had at least one companion gene. DNA methylation-related genes confer up to 62% incidence. TET2 highest mutation frequency (51%), followed by ASXL1 (17%), NPM1 (14%), CEBPA (13%), DNMT3A FLT3-ITD (11%), KIT IDH2 (9%), RUNX1 (8%), U2AF1 (7%) SF3B1...