A5001632689- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Multiple Myeloma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Hematological disorders and diagnostics
- Body Composition Measurement Techniques
- Chronic Lymphocytic Leukemia Research
- Heat shock proteins research
- Immune cells in cancer
- Nutrition and Health in Aging
- RNA Interference and Gene Delivery
- Cytokine Signaling Pathways and Interactions
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Lung Cancer Treatments and Mutations
- Histone Deacetylase Inhibitors Research
- Reproductive System and Pregnancy
- Scoliosis diagnosis and treatment
- interferon and immune responses
- Cancer-related molecular mechanisms research
- IL-33, ST2, and ILC Pathways
- Immunotherapy and Immune Responses
- Phagocytosis and Immune Regulation
- Immune Cell Function and Interaction
First Affiliated Hospital of Zhengzhou University
2016-2025
Shandong University of Science and Technology
2024
Dalian Medical University
2021-2022
Second Affiliated Hospital of Fujian Medical University
2018-2021
Fujian Medical University
2018-2021
Shenzhen Luohu People's Hospital
2020
Shenzhen University
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2018
Zhengzhou University
2014
Hebei Medical University
2014
Knowledge of immune cell phenotypes, function, and developmental trajectory in acute myeloid leukemia (AML) microenvironment is essential for understanding mechanisms evading surveillance immunotherapy response targeting special components.Using a single-cell RNA sequencing (scRNA-seq) dataset, we analyzed the bone marrow (BM) samples from 16 AML patients 4 healthy donors, but not blasts.We observed significant difference between normal BM cells. Here, defined diversity dendritic cells (DC)...
Abstract Myeloid sarcoma is a rare manifestation of acute myeloid leukemia (AML) and associated with poor overall survival (OS). The optimal treatment remains unclear. study retrospectively evaluated 118 patients who were treated at the First Affiliated Hospital Zhengzhou University from January 2010 to July 2021. All cases diagnosed by tissue biopsy. 41 underwent genetic mutation analysis. most frequent mutations KIT (16.6%), followed TET2 (14.6%), NRAS (14.6%). median time was 4 months...
Intermittent hypoxia (IH), a typical character of obstructive sleep apnea (OSA), is related to atherogenesis. However, the role IH on atherosclerosis (AS) progression and mechanisms involved remains poorly understood. In present study, high-fat fed ApoE−/− mice were treated with recombinant shRNA-TLR4 lentivirus exposed IH. Atherosclerotic lesions en face aorta cross-sections aortic root examined by Oil-Red O staining. The content lipids collagen plaques detected staining Sirius red...
Objective Abdominal adipose is closely related to many endocrine and metabolic diseases. The aim of this study was analyze the distribution abdominal tissue in a healthy population northern China determined by computed tomography (CT). Methods Data for were obtained from multicenter, retrospective, cross-sectional that collected CT scans 1787 individuals 4 representative cities China. Areas visceral (VATA) subcutaneous (SATA) measuring images at level 3rd lumbar vertebra. Visceral index...
Abstract This study was designed to explore whether exosomal sphingosine 1‐phosphate (S1P) from mesenchymal stem cells (MSCs) regulate the Treg/Th17 balance in aplastic anemia (AA) patients and validate underlying mechanism. To address this, exosomes human bone marrow MSCs (MSCs‐Exos) were co‐cultured with CD4 + T AA (AA cells), which transfected si‐S1PR1, si‐S1PR3, or not. The proportion of Th17 Treg evaluated by flow cytometry. levels Th17‐associated interleukin‐17 (IL‐17), Treg‐associated...
Abstract Anemia is a significant complication of chronic inflammation and may be related to dysregulated activities among erythroblastic island (EBI) macrophages. GM-CSF was reported upregulated attracted as therapeutic target in many inflammatory diseases. Among EBIs, we found that the receptor preferentially highly expressed EBI macrophages but not erythroblasts. treatment significantly decreases human formation vitro by decreasing adhesion molecule expression CD163. RNA-sequence analysis...
Abstract Silicon dioxide nanoparticles (SiO 2 NPs) are widely utilized in biomedicine due to their controllable size and biocompatibility. While previous studies have demonstrated that prenatal exposure SiO NPs can traverse the placental barrier induce neurotoxicity offspring. However, reproductive toxicity remains unclear. Here, it is found led subfertility female offspring, evidenced by decreased ovulation potential, ovarian reserve, litter size. In contrast, male offspring maintained...
To investigate the U2AF1 gene mutation site, load and co-mutations genes in patients with myelodysplastic syndrome (MDS) their effects on prognosis. Gene detection by next-generation sequence related clinical data of 234 MDS were retrospectively collected analyzed for relationship between characteristics, treatment efficacy prognosis mutation. Among patients, rate was 21.7% (51 cases), median variant allele frequency 39.5%. Compared wild type, mutant had a higher incidence chromosome 8...
Post-transplant relapse remains a principal leading cause of failure after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with adult acute lymphoblastic leukemia (ALL). The aim this study was to investigate the efficacy and safety low-dose decitabine on prevention ALL allo-HSCT.In prospective study, we enrolled 34 who underwent allo-HSCT from August 2016 April 2020 received maintenance treatment transplantation. primary objectives were cumulative incidence rate...
Abstract Background To investigate the correlation between triglyceride glucose index (TyG) and collateral circulation in patients with chronic total occlusion (CTO) of coronary arteries different metabolic states. Methods A 681 who underwent angiography January 2020 December 2021 to determine presence CTO lesions at least one major artery were retrospectively included this study. Patients categorized into a group poor formation (Rentrop grade 0–1, n = 205) good 2–3, 476) according Rentrop...
To the Editor: Allogeneic hemopoietic stem cell transplantation (allo-HSCT) represents only long-term survival treatment choice for patients with myelodysplastic syndromes (MDS) and MDS/myeloproliferative neoplasm (MPN). Unfortunately, post-hemopoietic (HSCT) relapse remains a cause of failure results salvage treatments are poor. Developing better conditioning regimens is urgently needed. Previous studies have shown synergistic antileukemic effects between decitabine (DEC) idarubicin...
6510 Background: Patients diagnosed with higher-risk myelodysplastic syndrome (MDS) have poor prognosis. Azacitidine (Aza) has been shown to prolong survival in patients treatment-naive, MDS compared a menu of standard care options. IMM01 is fusion protein comprising recombinant signal regulatory α (SIRPα) and IgG1, exerting anti-tumor effects by inhibiting the "Don't eat me" activating "Eat signal, leading robust antibody-dependent cellular phagocytosis (ADCP). Methods: This an open-label,...
Background The role of alprostadil and statins in contrast-induced acute kidney injury (CI-AKI) is controversial. purpose this study was to explore the efficacy combined therapy with protecting renal function preventing nephropathy (CIN) patients undergoing coronary angiography. Methods A total 156 consecutive mild moderate failure who underwent angiography were enrolled our study, randomly categorized into two groups. In group, 80 treated before after plus 76 Serum creatinine (SCr), serum...
Background: Atherosclerosis is closely associated with proliferation of the adventitial vasa vasorum, leading to atherosclerotic plaque progression and vulnerability. In this report, we investigated role Ginsenoside Rb 1 (Rb ) on stabilization vasorum (VV) along mechanisms involved. Methods Results: Apolipoprotein E-deficient (ApoE −/− mice were fed a high-fat diet for 20 weeks, then (50 mg/kg/d, intraperitoneal) was given 4 weeks. treatment significantly inhibited VV proliferation,...