A5100453415- SARS-CoV-2 and COVID-19 Research
- Retinoids in leukemia and cellular processes
- Acute Myeloid Leukemia Research
- Immunotherapy and Immune Responses
- Histone Deacetylase Inhibitors Research
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- Chronic Myeloid Leukemia Treatments
- Cancer Immunotherapy and Biomarkers
- Advanced biosensing and bioanalysis techniques
- Chronic Lymphocytic Leukemia Research
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Immune cells in cancer
- HIV Research and Treatment
- Protein Degradation and Inhibitors
- Hematopoietic Stem Cell Transplantation
- Estrogen and related hormone effects
- HIV/AIDS drug development and treatment
- Blood Coagulation and Thrombosis Mechanisms
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- Erythrocyte Function and Pathophysiology
- RNA Interference and Gene Delivery
Union Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2025
Fujian Medical University
2025
Soochow University
2023-2025
Duke University
2017-2024
Shandong First Medical University
2023-2024
Shanxi Medical University
2008-2024
Dian Diagnostics (China)
2024
Shandong Provincial Hospital
2024
Shanxi Academy of Medical Sciences
2024
BACKGROUND. Since December 2019, an outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) emerged in Wuhan, and is now becoming a global threat. We aimed to delineate compare the immunological features moderate COVID-19.
Limitation of infarct size is a major goal therapy for acute coronary syndromes, and research has focused on achieving rapid patency infarct-related vessels. However, new understandings epigenetic modifications during ischemia suggest additional targeted approaches that have not been extensively explored. Here, we show induces histone deacetylase (HDAC) activity in the heart with deacetylation histones H3/4 vitro vivo. We show, utilizing standard murine model ischemia-reperfusion, chemical...
As the COVID-19 pandemic rages on, new SARS-CoV-2 variants have emerged in different regions of world. These newly mutations their spike (S) protein that may confer resistance to vaccine-elicited immunity and existing neutralizing antibody therapeutics. Therefore, there is still an urgent need safe, effective, affordable agents for prevention/treatment its variant infection.We demonstrated green tea beverage (GTB) or major ingredient, epigallocatechin gallate (EGCG), were highly effective...
BMS-378806 is a recently discovered small-molecule human immunodeficiency virus type 1 (HIV-1) attachment inhibitor with good antiviral activity and pharmacokinetic properties. Here, we demonstrate that the compound targets viral entry by inhibiting binding of HIV-1 envelope gp120 protein to cellular CD4 receptors via specific competitive mechanism. binds directly at stoichiometry approximately 1:1, affinity similar soluble CD4. The potential target site was localized region within pocket...
Abstract Although fully MHC-mismatched murine cardiac allografts are rapidly rejected, mismatched at only MHC class I or II alleles survive long term; the immunologic basis for long-term survival of I- II-mismatched is unknown. We examined roles two recently described inhibitory receptors, B and T lymphocyte attenuator (BTLA) programmed death-1 (PD-1), in partially using gene-deficient recipients as well through use blocking mAbs wild-type hosts. Partially showed strong induction BTLA, but...
Tumor-infiltrating lymphocytes are considered to represent a host immune response against tumor. This study was carried out analyze the effect of both FoxP3+ regulatory T cells (Tregs) and CD8+ in prognostic value hepatocellular carcinoma (HCC) patients.Expressions FoxP3, CD4, CD8 CD34 patient-matched tumors peritumoral tissues were assessed by immunohistochemistry for 54 HCC patients. The groups with high low numbers evaluated Kaplan-Meier Cox model analysis using median values as...
The testis is an immunoprivileged site, where the local cell-initiated testicular innate immune responses play a crucial role in defense against microbial infections. Mechanisms modulating cell-built system remain to be clarified. In this article, we demonstrate that Leydig cells, major cell population interstitium, initiate immunity through activation of Toll-like receptors (TLRs). Several TLRs are expressed mouse cells; among these, TLR3 and TLR4 at relatively high levels compared with...
Elemene (C15H24) is a sesquiterpene compound extracted from the rhizome of Curcuma herbs. In past decades, anti-tumor activity elemene has been observed in vitro and some clinical practices. However, pharmacological mechanisms are not demonstrated adequately, which may lead to improper applications. This study aimed investigate effect nanoemulsion mouse model triple-negative breast cancer (TNBC) reveal underlying mechanisms.The ESR measurement quantum mechanics simulation were used...
Two HER2-specific mAbs, trastuzumab and pertuzumab (T+P), combined with chemotherapy comprise standard-of-care treatment for advanced HER2+ breast cancers (BC). While this antibody combination is highly effective, its synergistic mechanism-of-action (MOA) remains incompletely understood. Past studies have suggested that the synergy underlying occurs through different mechanisms elicited by these antibodies, suppressing HER2 heterodimerization inducing antitumor immunity. However, in vivo...
Cellulose sulfate, a polyanionic compound derived from cotton, has been proposed as topical microbicide to reduce the sexual transmission of HIV. However, phase III clinical trial vaginal gel formulation cellulose sulfate (Ushercell) had be prematurely closed after early data indicated users higher rate HIV infection than women using placebo. The unexpected results trail prompted us reexamine and attempt replicate available preclinical for this other polyanions. We show here that biphasic...
ER+ breast cancers (BC) are characterized by the elevated expression and signaling of estrogen receptor alpha (ESR1), which renders them sensitive to anti-endocrine therapy. While these therapies clinically effective, prolonged treatment inevitably results in therapeutic resistance, can occur through emergence gain-of-function mutations ESR1. The central importance ESR1 development mutated forms suggest that vaccines targeting proteins could potentially be effective preventing or treating...
Relapsed/refractory acute myeloid leukemia (rrAML) is a malignant blood cancer with an extremely poor prognosis, largely ascribed to the drug-resistant stem cells (LSCs). Most patients suffer from risk of difficult-to-cure as well severe systemic toxicity when receiving standard chemotherapies. As hyaluronic acid (HA) specific ligand CD44 highly expressed by LSCs, we had HA self-assembled cisplatin and daunorubicin form dual chemodrug nanogel (HA/Cis/Dau) afford targeted therapeutic...
Abstract Background Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spreads rapidly and has a high case-mortality rate. The nucleocapsid protein (NP) of SARS-CoV may be critical for pathogenicity. This study sought to discover the host proteins that interact with NP. Results Using surface plasmon resonance biomolecular interaction analysis (SPR/BIA) matrix-assisted laser desorption/ionization time flight (MALDI-TOF) mass spectrometry, we found only proteasome subunit p42...
The testis is an immunoprivileged site where local cell-initiated innate immunity plays a crucial role in antimicrobial responses. Toll-like receptors (TLRs) mediate immune responses testicular somatic cells. Although several TLRs are expressed some stages of male germ cells, the potential triggering cells has yet to be exclusively studied. current study demonstrates that TLR3 constitutively spermatogonia and spermatocytes can activated by synthetic double-strained RNA analog,...