A5100414609- Nanoparticles: synthesis and applications
- RNA Interference and Gene Delivery
- Acute Myeloid Leukemia Research
- Graphene and Nanomaterials Applications
- Chronic Myeloid Leukemia Treatments
- Electrospun Nanofibers in Biomedical Applications
- Heavy Metal Exposure and Toxicity
- Advanced biosensing and bioanalysis techniques
- Retinoids in leukemia and cellular processes
- Retinal Diseases and Treatments
- Nanoparticle-Based Drug Delivery
- Erythrocyte Function and Pathophysiology
- Retinal Imaging and Analysis
- Tissue Engineering and Regenerative Medicine
- Immunotherapy and Immune Responses
- Lanthanide and Transition Metal Complexes
- Nanoplatforms for cancer theranostics
- Curcumin's Biomedical Applications
- MicroRNA in disease regulation
- Advanced Nanomaterials in Catalysis
- Antimicrobial Peptides and Activities
- Estrogen and related hormone effects
- Histone Deacetylase Inhibitors Research
- Drug Transport and Resistance Mechanisms
- Cancer, Lipids, and Metabolism
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Merck & Co., Inc., Rahway, NJ, USA (United States)
2024
United States Military Academy
2024
Chongqing Medical University
2023
Central Hospital of Zibo
2023
Guangzhou University
2021-2022
Peking Union Medical College Hospital
2014-2022
Peking University
2022
Peking University People's Hospital
2022
University of Bristol
2022
Drug discovery for malaria has been transformed in the last 5 years by of many new lead compounds identified phenotypic screening. The process developing these as drug leads and studying cellular responses they induce is revealing targets that regulate key processes Plasmodium parasites cause malaria. We disclose herein clinical candidate (+)-SJ733 acts upon one targets, ATP4. ATP4 thought to be a cation-transporting ATPase responsible maintaining low intracellular Na(+) levels parasite....
Based on the molecular stent concept, a series of tough double-network hydrogels (St-DN gels) made from components proteoglycan aggregates – chondroitin sulfate proteoglycans (1), (2), and sodium hyaluronate (3) are successfully developed in combination with neutral biocompatible polymer. This work demonstrates promising method to create biopolymer-based for biomedical applications.
Administration of silver nanoparticles (AgNPs) to mice could result in their distribution and accumulation multiple organs, with notable prominence liver, lungs, kidneys. However, how AgNPs transport through blood vesicular system reach the target organs is unclear, precise differences mechanisms toxicity between ions still remain elusive. In present research, pathological changes on these a focus inter-endothelial junction was investigated gain new insight by comparing action AgNO3. We...
Macular subretinal fibrosis is the end-stage complication of neovascular age-related macular degeneration (nAMD). We previously developed a mouse model two-stage laser-induced that mimics closely dynamic course in nAMD patients. This study was aimed to understand molecular mechanism fibrosis.Subretinal induced C57BL/6J mice using protocol. Twenty days later, eyes were collected and processed for RNA sequencing (RNA-seq) analysis. DESeq2 used determine differentially expressed genes (DEGs)....
Silver nanoparticles (NPs) have been widely explored as antibacterial and antifungal agents in households, cosmetics, food packaging, medical devices even various wound care products. With the application of silver NPs biomedicine expanding, safety issue is attracting ever-growing attention. Although increasing literatures evidenced that induce reactive oxygen species (ROS) mammalian cells thus resulted cell damage, mechanisms how these initiate ROS accumulation are open questions. In this...
Elemene (C15H24) is a sesquiterpene compound extracted from the rhizome of Curcuma herbs. In past decades, anti-tumor activity elemene has been observed in vitro and some clinical practices. However, pharmacological mechanisms are not demonstrated adequately, which may lead to improper applications. This study aimed investigate effect nanoemulsion mouse model triple-negative breast cancer (TNBC) reveal underlying mechanisms.The ESR measurement quantum mechanics simulation were used...
Retinal fibrosis affects 40-70% of neovascular age-related macular degeneration patients. This study investigated the effect ageing on subretinal secondary to choroidal neovascularization and mechanism action.Subretinal was induced in young (2.5-month) aged (15-16-month) C57BL/6J mice using two-stage laser protocol. Five 30 days later, eyes were collected stained for CD45 collagen-1 observed by confocal microscopy. Fibrocytes (CD45+collagen-1+) detected bone marrow (BM), blood fibrotic...
Aberrant arachidonic acid metabolism by cyclooxygenase (COX)-2 and 12-lipoxygenase (LOX) has implicated in carcinogenesis. Genetic polymorphisms COX-2 12-LOX might therefore affect susceptibility to colorectal cancer (CRC). To examine this hypothesis, genotypes of -1290A>G, -1195G>A, -765G>C 261Arg>Gln were determined 1000 CRC patients 1300 controls. Increased risk developing was associated with the -1195GA [adjusted odds ratio (OR) = 1.24, 95% confidence interval (CI) 1.00-1.54] -1195AA...
The aim of this work was to probe the biodistribution and toxic effects silver nanoparticles (NPs) with powerful anti-bacterial anti-virus activities. For purpose, novel NPs gold nanorod (NR) core shell (Au@Ag NRs) were developed employed as a model material. inner provided an excellent internal reference for tracking NRs in vivo. After subcutaneous injection Au@Ag NRs, contents subcutis organs examined by inductively coupled plasma mass spectrometry at different time points within 28 days....
Most of the existing scaffolds for guiding tissue regeneration do not provide direct mechanical stimulation to cells grown on them. In this work, we used nanofibrous superparamagnetic with applied magnetic fields build a "dynamic" scaffold platform and investigated modulating effects phenotypes fibroblasts. The results enzyme-linked immunosorbent transwell assays indicated that fibroblasts cultivated in secreted significantly higher type I collagen, vascular endothelial growth factor A,...
Iron oxide nanoparticles (IONPs) have been extensively studied in different biomedical fields. Recently, the non-cytotoxic concentration of IONPs induced cell-specific response raised concern their safety. Endothelial cell exposure was unavoidable applications, while whether affect phenotype vascular endothelial cells is largely unknown. In this work, effect on endothelial-to-mesenchymal transition (EndMT) investigated vitro and vivo. The incubation with γ-Fe2O3 modified polyglucose sorbitol...
Effective and quick screening cardiotoxicity assessment are very crucial for drug development. Here, a novel composite hydrogel composed of carbon fibers (CFs) with high conductivity modulus polyvinyl alcohol (PVA) is reported. The the PVA/CFs similar to that natural heart tissue, elastic close tissue during systole, due incorporation CFs. remarkably enhance maturation neonatal rat cardiomyocytes (NRCM) in vitro by upregulating expression α-actinin, troponin T, connexin-43, activating...
Effects of different nanoparticles (NPs) exposure at acutely non-cytotoxic concentrations are particularly worthy to figure out, compare, and elucidate.To investigate compare the effect a small library NPs concentration on adherens junction human umbilical vein endothelial cells (HUVECs), obtaining new insights safety evaluation.The HUVECs layer was exposed including gold (Au), platinum (Pt), silica (SiO2), titanium dioxide (TiO2), ferric oxide (Fe2O3), oxidized multi-walled carbon...
As4S4 is a mineral drug that can be administrated orally and has been applied in the treatment of myeloid leukemia. The aim this work to investigate therapeutic effect highly metastatic triple-negative breast cancer animal model, as not yet. To overcome poor solubility original As4S4, formulation hydrophilic nanoparticles (e-As4S4) developed previously was mouse cells well tumor-bearing mice. It shown e-As4S4 much more cytotoxic than r-As4S4, strongly inhibiting proliferation scavenging...
Here we demonstrated that the stiffness of cationized gelatin nanoparticles determined efficiency RNAi in myeloid leukemia cells when particle size and surface charges were kept constant. The siRNA delivery system with an elastic modulus 0.87 MPa showed largest uptake for hard-to-transfect suspension cells.
Acute myeloid leukemia (AML) is the most common adult acute with very low survival rate due to drug resistance and high relapse rate. The C-X-C chemokine receptor 4 (CXCR4) highly expressed by AML cells, actively mediating chemoresistance reoccurrence. Herein, a chemically synthesized CXCR4 antagonistic peptide E5 fabricated micelle formulation (M-E5) applied refractory mice, its therapeutic effects pharmacokinetics are investigated. Results show that M-E5 can effectively block surface in...