A novel nanofibrous composite scaffold composed of super-paramagnetic γ-Fe2O3 nanoparticles (MNP), hydroxyapatite (nHA) and poly lactide acid (PLA) was prepared using electrospinning technique. The well responds extern static magnetic field with typical saturation magnetization value 0.049 emu/g as possesses architecture. scaffolds were implanted in white rabbit model lumbar transverse defects. Permanent magnets are fixed the cages to provide for rabbits post surgery. Results show that MNP...

Abstract Multidrug resistance (MDR) is a major impediment to cancer treatment. A promising strategy for treating MDR the joint delivery of combined anticancer agents tumor cells in single nanocarrier. Here, first time, Resveratrol (Res) was co-encapsulated with paclitaxel (PTX) PEGylated liposome construct carrier-delivered form combination therapy drug-resistant tumors. The composite had an average diameter 50 nm encapsulated efficiencies above 50%. studies demonstrated that could generate...

MUC1 protein is an attractive target for anticancer drug delivery owing to its overexpression in most adenocarcinomas. In this study, a reported aptamer exploited as the targeting agent of nanoparticle-based system. Paclitaxel (PTX) loaded poly (lactic-co-glycolic-acid) (PLGA) nanoparticles were formulated by emulsion/evaporation method, and aptamers (Apt) conjugated particle surface through DNA spacer. The (Apt-NPs) are about 225.3 nm size with stable vitro release profile. Using MCF-7...

Administration of silver nanoparticles (AgNPs) to mice could result in their distribution and accumulation multiple organs, with notable prominence liver, lungs, kidneys. However, how AgNPs transport through blood vesicular system reach the target organs is unclear, precise differences mechanisms toxicity between ions still remain elusive. In present research, pathological changes on these a focus inter-endothelial junction was investigated gain new insight by comparing action AgNO3. We...

The potential applications of superparamagnetic iron oxide nanoparticles (SPIONs) in several nanomedical fields have attracted intense interest based on the cell-nano interaction. However, mechanisms underlying cell uptake, intracellular trail, final fate and biological effects SPIONs not yet been clearly elucidated. Here, we showed that multiple endocytic pathways were involved internalization process RAW264.7 macrophage. internalized biocompatible used three different metabolic pathways:...

Abstract The biomedical applications of carbon nanotubes (CNTs) have attracted deep interest in recent years. Antitumor immunotherapy has the potential to improve prognosis cancer treatment but efficacy current generally needs further improvement. Multi‐walled CNTs conjugated tumor lysate protein are investigated as whether they would enhance an employing a tumor‐cell vaccine mouse model bearing H22 liver cancer. cure rate is found be markedly improved by protein. cellular antitumor immune...

In this work, a paramagnetic nanofibrous composite film was fabricated with poly lactide, hydroxyapatite and γ-Fe(2)0(3) nanoparticles using the electrospinning technique. The significantly enhanced proliferation, differentiation ECM secretion of osteoblast cells under static magnetic field, which offers promising application potentials in bone tissue engineering regeneration therapy.

Biomedical application potentials of carbon nanotubes-based materials have been investigated intensively in recent years; however, characterization and metrology are still facing great technical challenges when the intended to be used as carriers for therapeutics aqueous solutions. Systematic on dispersing nanotubes is urgently required therefore significance. In this paper multiwalled (MWCNTs) with different average lengths or oxidation degrees were dispersed water characterized...

Silver nanoparticles (NPs) have been widely explored as antibacterial and antifungal agents in households, cosmetics, food packaging, medical devices even various wound care products. With the application of silver NPs biomedicine expanding, safety issue is attracting ever-growing attention. Although increasing literatures evidenced that induce reactive oxygen species (ROS) mammalian cells thus resulted cell damage, mechanisms how these initiate ROS accumulation are open questions. In this...

The potential of carbon nanotubes (CNTs) in medical applications has been attracting constant research interest as well raising concerns related to toxicity. immune system serves the first line defense against invasion. In this work, interactions oxidized multiwalled (MWCNT) with macrophages were investigated unravel activation profile macrophages, using cytokine array, ELISA assay, transwell confocal microscopy, and reactive oxygen species examination. Results show that MWCNT initiate...

Elemene (C15H24) is a sesquiterpene compound extracted from the rhizome of Curcuma herbs. In past decades, anti-tumor activity elemene has been observed in vitro and some clinical practices. However, pharmacological mechanisms are not demonstrated adequately, which may lead to improper applications. This study aimed investigate effect nanoemulsion mouse model triple-negative breast cancer (TNBC) reveal underlying mechanisms.The ESR measurement quantum mechanics simulation were used...

Abstract Blood compatibility has been an occlusion for biomaterials used in the cardiovascular system. In this work, a multiwalled carbon nanotubes‐polyurethane composite (MWNT‐PU) was prepared through controlled co‐precipitation. The surface chemical composition of treated nanotubes analyzed with XPS and thermal behaviors were characterized by DSC. platelet adhesion activation caused evaluated using SEM flow cytometric analysis, respectively, disruption red blood cells measuring absorbance...

The advancement in nanotechnology has produced technological and conceptual breakthroughs but the effects nanomaterials have on organisms at cellular level are poorly understood. Here we report that carboxyl-terminated multi-walled carbon nanotubes (MWCNTs) act as antagonists of three types potassium channels assessed by whole-cell patch clamp electrophysiology undifferentiated pheochromocytoma (PC12) cells. Our results showed MWCNTs suppress current densities Ito, IK IK1 a time-dependent...

Gold nanorods (AuNRs) have been largely investigated driven by their promising potentials in drug delivery, imaging, and photodynamic therapy because of distinctive physicochemical properties. It is widely known that AuNRs can be taken up different cells, however, the trafficking cells are less known. In this work, behaviors fate human breast cancer cell line MDA-MB-231 were intensively probed transmission electron microscopy (TEM) with detailed time resolution, together induced couple...

This study focused on the potential toxicity of silver nanoparticles (AgNPs) cardiac electrophysiology which is rarely investigated. We found that AgNPs (10-9-10-6 g/ml) concentration-dependently depolarized resting potential, diminished action and finally led to loss excitability in mice papillary muscle cells vitro. In cultured neonatal cardiomyocytes, (10-9-10-7 decreased Na+ currents (INa), accelerated activation, delayed inactivation recovery channels from within 5 min. at 10-8 g/ml...

Pimavanserin is a new non-dopamine neurotransmitter antipsychotic drug. This study aimed to conduct post-marketing pharmacovigilance of pimavanserin, through data mining technology using the FDA Adverse Event Reporting System (FAERS) database. We analyzed adverse event reports for patients pimavanserin. Data were classified systematic organ classification (SOC) and preferred term (PT) Medical Dictionary Regular Activities (MedDRA). Four signal algorithms [reporting odds ratio (ROR),...

Relapsed/refractory acute myeloid leukemia (rrAML) is a malignant blood cancer with an extremely poor prognosis, largely ascribed to the drug-resistant stem cells (LSCs). Most patients suffer from risk of difficult-to-cure as well severe systemic toxicity when receiving standard chemotherapies. As hyaluronic acid (HA) specific ligand CD44 highly expressed by LSCs, we had HA self-assembled cisplatin and daunorubicin form dual chemodrug nanogel (HA/Cis/Dau) afford targeted therapeutic...

Carbon nanotubes have attracted intensive interests in biomedical research recent years. In this study, a novel type of carbon material so called nonwoven single-walled (SWNTs) with nanotopographic structure and macroscopic volume was used as cell growing scaffold. The morphology surface chemistry SWNTs were observed characterized through scanning electron microscopy X-ray photoelectron spectroscopy, respectively. cells cultivated other types substrate control. growth behaviors including...

The immunological responses induced by oxidized water-soluble multi-walled carbon nanotubes on a hepatocarcinoma tumor-bearing mice model via local administration of subcutaneous injection were investigated. Experimental results show that the subcutaneously injected significant activation complement system, promoted inflammatory cytokines' production and stimulated macrophages' phagocytosis activation. All these increased general activity host immune system inhibited progression tumor growth.

Abstract In this work, the effect of nanofibrous structure and multiwalled carbon nanotubes (MWNTs) incorporation in polyurethane (PU) on fibroblasts growth behavior was studied. The scaffold composite (MWNT/PU) with an average fiber diameter 300–500 nm fabricated by electrospinning technique. PU, smooth film MWNT/PU were also prepared as controls. Cell viability assay, laser confocal microscopy, scanning electron microscopy applied to evaluate cell adhesion, proliferation, cytoskeletal...