A5085326258- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Nanocluster Synthesis and Applications
- Covalent Organic Framework Applications
- Metal-Organic Frameworks: Synthesis and Applications
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Carbon and Quantum Dots Applications
- Luminescence and Fluorescent Materials
- MicroRNA in disease regulation
- Graphene and Nanomaterials Applications
- Salmonella and Campylobacter epidemiology
- Bone and Dental Protein Studies
- Bone Tissue Engineering Materials
- Parallel Computing and Optimization Techniques
- Biopolymer Synthesis and Applications
- Chemokine receptors and signaling
- PI3K/AKT/mTOR signaling in cancer
- Mesoporous Materials and Catalysis
- Skin Protection and Aging
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Cancer, Lipids, and Metabolism
Hangzhou Medical College
2024
Zhejiang Sci-Tech University
2023-2024
Shanghai Jiao Tong University
2022-2024
Shandong Normal University
2020-2023
Southeast University
2020-2022
State Key Laboratory of Digital Medical Engineering
2020-2022
Fudan University
2016-2021
State Key Laboratory of Genetic Engineering
2020-2021
California Maritime Academy
2021
Qufu Normal University
2019
As pioneering Fe
Anthracycline-induced liver injury (AILI) is becoming an increasingly serious and potential clinical complication linked to reactive oxygen species (ROS) production subsequent inflammatory response. Herein, we demonstrated that artificial Prussian blue nanozymes (PBZs) prevented daunorubicin-induced injury, a prototype of AILI, by attenuating ROS regulating inflammation. PBZs exhibited multienzyme activity could scavenge free radicals. At the cellular level, effectively eliminate ROS,...
Imaging-guided phototherapy, including photothermal therapy and photodynamic therapy, has been emerging as a promising avenue for precision cancer treatment. However, the utilization of single laser to induce combination phototherapy multiple-model imaging remains great challenge. Herein, we report, first its kind, covalent–organic framework (COF)-based magnetic core–shell nanocomposite, Fe3O4@COF-DhaTph, that is used multifunctional nanoagent theranostics under 660 nm NIR irradiation....
Mesoporous silica nanoparticles (MSN) have been widely applied for drug delivery systems. To investigate the effects of pore size on anticancer efficacies, MSN with different sizes but similar particle and surface charges were synthesized via a microemulsion method. The structures characterized by transmission electron microscopy (TEM), small-angle X-ray scattering (SAXS), N2 adsorption-desorption isotherms. Doxorubicin loaded (DOX/MSN) prepared minimum loading capacity was detected in...
Despite the progress made to improve therapeutic outcomes for acute myeloid leukemia (AML), many unmet clinical needs remain be resolved. Unlike existing anti-AML strategies, here we developed a biomimetic nanocomposite efficiently eliminate cells in bone marrow and prevent homing of AML. To fulfill our design, ultra-small nanozyme was conjugated onto surface an oxygen-carrying nanoparticle, which further coated with stromal cell membrane. After entering blood, this got actively internalized...
We report a Cu(<sc>ii</sc>)-porphyrin-derived COF which can be H<sub>2</sub>S triggered nanoagent to achieve collaborative PDT and PTT against colon cancer.
We summarize and illustrate the recent developments of MOF- COF-based nanomedicines for PDT its combined antitumor treatments. Furthermore, major challenges future development prospects in this field are also discussed.
Illustration of HMPBs(DNR + AraC)@PEI-ZS-E5 for targeted and synergetic chemo-photothermal treatment AML. The nanoplatform showed excellent photothermal effects, reduced protein adsorption remarkable targeting/chemo/photothermal effects.
External light-independent antitumor PDT is successfully realized with a covalent organic framework (COF)-based host-guest nanosystem. Its highly effective behavior fully demonstrated by both H2O2-overexpressed 4T1 and H2O2-less expressed HCT116 MCF-7 xenograft models.
A novel, rapid and sensitive lateral flow fluorescent immunoassay combined with strand exchange amplification (SEA-LFIA) for the quantitative detection of<italic>Salmonella</italic>spp. was developed.
Benzylguanidine, a small cationic and amphiphilic molecule, exhibits high affinity to C-X-C chemokine receptor type 4 (CXCR 4) membrane penetration ability. It has not been used as functional moiety of nanocarriers for the systemic delivery chemotherapeutic drugs in tumor therapy. In this study, we investigated benzylguanidine-conjugated their efficiency safety targeted doxorubicin (DOX) CXCR positive tumors. We conjugated benzylguanidine bearing guanidinobenzoic acid onto cystamine...
The targeted delivery of drugs to tumor cells and prevention premature release before reaching the target is one key challenges developing nanomedicines. In this paper, galactose decorated trimethyl chitosan (GT)-camptothecin (CPT) prodrug nanoparticles (GT-ss-CPT NPs) were prepared from GT-CPT conjugates linked by dithiodipropionic acid. obtained GT-ss-CPT NPs spherical with a particle size 184.1 nm. displayed low drug under physiological conditions, whereas efficient was triggered high GSH...
The main reasons for the difficulty in curing and high recurrence rate of glioblastoma multiforme (GBM) include: 1. chemotherapy drugs penetrating blood-brain barrier (BBB) to target tumor cells; 2. presence glioma stem cells (GSCs) leading resistance. Therefore, breaking through limitations BBB overcoming drug resistance caused by GSCs are strategies address this problem. This study presents our results on development lactoferrin (Lf)/CD133 antibody conjugated nanostructured lipid carriers...