A5101472963- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Spine and Intervertebral Disc Pathology
- RNA modifications and cancer
- Circular RNAs in diseases
- Medical Imaging and Analysis
- Autophagy in Disease and Therapy
- Spinal Fractures and Fixation Techniques
- Advanced biosensing and bioanalysis techniques
- CRISPR and Genetic Engineering
- Biochemical effects in animals
- Insect and Arachnid Ecology and Behavior
- Selenium in Biological Systems
- Liver Disease Diagnosis and Treatment
- RNA and protein synthesis mechanisms
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- HER2/EGFR in Cancer Research
- Bone fractures and treatments
- Monoclonal and Polyclonal Antibodies Research
- Neonatal Respiratory Health Research
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
Fudan University
2025
Huadong Hospital
2025
China Medical University
2018-2024
Zhongkai University of Agriculture and Engineering
2024
Shanghai Municipal Center For Disease Control Prevention
2024
Eye & ENT Hospital of Fudan University
2021-2024
Shanghai Clinical Research Center
2024
University School
2017-2023
Case Western Reserve University
2016-2023
Gansu Academy of Agricultural Sciences
2023
Significance Pressure overload triggers responses in cardiomyocytes and noncardiomyocytes, leading to pressure hypertrophy (POH). Here, we show that cardiac resident macrophages regulate compensatory myocardial adaptation POH, while nonresident infiltrating are detrimental. At early-phase induces macrophage proliferation, which is regulated by Kruppel-like factor 4. late-phase also Ly6C hi monocyte infiltration, its blockade improves angiogenesis preserves function. Mechanistically, the...
Immunostimulatory antibody conjugates (ISACs) as a promising new generation of targeted therapeutic antibody-drug (ADCs), that not only activate innate immunity but also stimulate adaptive immunity, providing dual effect to eliminate tumor cells. However, several ISACs are still in the early stages clinical development or have already failed. Therefore, it is crucial design more effectively overcome their limitations, including high toxicity, strong immunogenicity, long time, and poor...
A cure for heart failure remains a major unmet clinical need, and current therapies targeting neurohomonal hemodynamic regulation have limited efficacy. The pathological remodeling of the myocardium has been associated with stereotypical gene expression program, which had long viewed as consequence not driver disease until very recently. Despite advance, there is no therapy available to reverse already committed program. Here, we demonstrate that transcriptional repressor REV-ERB binds near...
Abstract Neurons within the cerebellum form temporal–spatial connections through cerebellum, and entire brain. Organoid models provide an opportunity to model early differentiation of developing human which is difficult study in vivo, affords neurodegenerative neurodevelopmental diseases cerebellum. Previous cerebellar organoid focused on neuron generation single cell activity. Here, we modify previous protocols generate more mature organoids that allow for establishment several classes...
Background: Markers of aging hold promise in the context colorectal cancer (CRC) care.Utilizing high-resolution metabolomic profiling, we can unveil distinctive age-related patterns that have potential to predict early CRC development.Our study aims unearth a panel markers and delve into alterations associated with CRC.Methods: We assembled serum cohort comprising 5,649 individuals, consisting 3,002 healthy volunteers, 715 patients diagnosed advanced precancerous lesions (APL), 1,932...
Fullerenes C60 shows great potential for drug transport. generates large amounts of singlet oxygen upon photoexcitation, which has a significant inhibitory effect on tumor cells, so the photosensitive properties were exploited photodynamic therapy tumors by laser irradiation. In this study, C60-NH2 was functionalized introducing amino acids surface C60, coupled with 5-FU to obtain acid-derived drugs (C60AF, C60GF, C60LF), and activated (C60AFL, C60GFL, C60LFL) obtained The...
Abstract Phenotypic screening of cell-cell and cell-matrix interactions is critical yet challenging for drug discovery disease modeling. In this study, a scalable 3D tissue platform was developed by co-laying extracted natural insoluble collagen fibers, mesenchymal stem cells, endothelial neural progenitor cells phenotypic screening. Cell growth were enhanced in the co-laid platform, evident through increased cell proliferation, viability, vascularization. Dense vascular networks rapidly...
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality, particularly due to advanced-stage metastasis. P-cadherin (CDH3), potential therapeutic target, is highly expressed in CRC tissues and associated with poor prognosis However, the mechanisms underlying its role progression translational remain poorly understood. This study integrated multiple public databases (TCGA, HCMDB, UALCAN, HPA, UniProt, cBioPortal, GEO) evaluate CDH3 expression, construct prognostic model,...
To investigate whether sequestosome 1/p62 (p62), a key cargo adaptor protein involved in both the ubiquitin-proteasome system and autophagy-lysosome system, could directly regulate autophagy vitro. HEK 293 cells or HeLa were transfected with p62-expressing plasmids siRNA targeting p62. The cell lysates subsequently subjected to immunofluorescence assay, immunoprecipitation immunoblot analysis. In vitro pulldown assay was used study interaction of p62 Bcl-2. Overexpression significantly...
Drosophila Polycomb (PC), a subunit of repressive complex 1 (PRC1), is well known for its role in maintaining repression the homeotic genes and many others binding to trimethylated histone H3 on Lys 27 (H3K27me3) via chromodomain. Here, we identify novel activity PC: inhibition acetylation CREB-binding protein (CBP). We show that PC mammalian CBX orthologs interact directly with acetyltransferase (HAT) domain CBP, previously identified autoregulatory loop, whose autoacetylation greatly...
Ocular toxicities are among the most common adverse events resulting from targeted anticancer agents and becoming increasingly relevant in management of patients on these agents. The purpose this study is to provide a framework for challenging based objective data FDA labels analysis literature. All oncologic drugs approved by up March 14, 2015, were screened inclusion. A total 16 (12 small-molecule 4 monoclonal antibodies) analyzed ocular toxicity profiles evidence toxicity. Trials cited...
MicroRNA-122 (miR-122) is one of several microRNAs elevated in heart failure patients. To investigate the potential role and mechanism miR-122 failure, we constructed a transgenic mouse overexpressing heart. This exhibited cardiac dysfunction (as assessed by transthoracic echocardiography), morphological abnormalities cardiomyocyte apoptosis characteristic failure. Mechanistically, identified Hand2 transcription factor as direct target using dual-luciferase reporter assay. In Tg-miR-122 mice...
The objective of present study was to investigate the effects alpha-lipoic acid (ALA) dietary supplementation on behavior, physiological and oxidant stress indicators, bone quality in broilers under high stocking density (HSD) stress. A total one thousand eight hundred 22-day-old Arbor Acres male broiler chicks were randomly allocated 18 pens (2.97 × 2.03 m) 3 groups: 14 birds/m2 (NSD, normal density) or plus 300 mg/kg ALA supplement (HSD + ALA, acid). Each treatment had 6 replicates,...
In search of active nucleoside 5'-triphosphate mimics, we have synthesized a series AZT triphosphate mimics (AZT P3Ms) and evaluated their inhibitory effects on HIV-1 reverse transcriptase as well stability in fetal calf serum CEM cell extracts. Reaction with 2-chloro-4H-1,3,2-benzodioxaphosphorin-4-one, followed by treatment the phosphite intermediate 2 pyrophosphate analogues, yielded cyclic intermediates 4b-4f, which were subjected to boronation subsequent hydrolysis give...
Abstract Substantial evidence implicates crosstalk between metabolic tissues and the immune system in inception progression of obesity. However, molecular regulators that orchestrate metaflammation both centrally peripherally remains incompletely understood. Here, we identify myeloid Krüppel-like factor 2 (KLF2) as an essential regulator obesity its sequelae. In mice humans, consumption a fatty diet downregulates KLF2 levels. Under basal conditions, myeloid-specific knockout (K2KO) exhibit...
Abstract Background Immunotherapy is a vital component in cancer treatment. However, due to the complex genetic bases of cancer, clear prediction index for efficacy has not been established. Tumor mutation burden (TMB) one essential factors that affect immunotherapeutic efficacies, but it determined whether associated with survival Skin Cutaneous Melanoma (SKCM) patients. This study aimed at evaluating correlation between TMB and immune infiltration. Methods Somatic profiles ( n = 467),...
Secoemestrin C is an epitetrathiodioxopiperazine isolated from Aspergillus nidulans, which has only been reported in terms of inhibiting tumor cell proliferation. Here, we determined the immunomodulatory and hepatoprotective effects secoemestrin a mouse model acute autoimmune hepatitis. In vitro assay, purified hepatic mononuclear cells (MNCs) C57BL/6J mice were stimulated with concanavalin A (Con A) presence C, proliferation cytokine production measured. vivo or without pretreatment...