A5100406722- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Radiomics and Machine Learning in Medical Imaging
- Kruppel-like factors research
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- Monoclonal and Polyclonal Antibodies Research
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Prostate Cancer Treatment and Research
- Chronic Lymphocytic Leukemia Research
- Metal complexes synthesis and properties
- MicroRNA in disease regulation
- Renal cell carcinoma treatment
- FOXO transcription factor regulation
- Inflammatory Biomarkers in Disease Prognosis
Genmab (United States)
2022-2025
Shanghai Jiao Tong University
2013-2024
Shanghai Cancer Institute
2016-2024
Nanjing Medical University
2010-2024
Fujian Electric Power Survey & Design Institute
2024
Beijing University of Chinese Medicine
2022-2024
Guangdong Ocean University
2024
Renji Hospital
2016-2023
Chengdu Second People's Hospital
2023
Shanghai First People's Hospital
2011-2023
Abstract Caveolin-1 (Cav-1), a principal structural component of caveolar membrane domains, contributes to cancer development but its precise functional roles and regulation remain unclear. In this study, we determined the oncogenic function Cav-1 in preclinical models pancreatic human tissue specimens. expression levels correlated with metastatic potential epithelial–mesenchymal transition (EMT) both mouse cells. Elevated cells promoted EMT, migration, invasion, metastasis animal models,...
Macrophages play a critical role in the initiation and progression of various solid tumors. However, their prognostic significance pancreatic ductal adenocarcinoma (PDAC) is poorly understood. This study investigated distribution patterns macrophages PDAC possible association with overall survival (OS). We found significant differences macrophage density (identified by CD68 CD163 immunopositivity; p < 0.001 for both) between primary cancer paired adjacent normal tissues. Most cancerous...
Purpose: Pancreatic cancer is a highly aggressive malignant tumour with poor prognosis. The median survival only 6 months. This study investigated the prognostic value of nuclear export protein chromosomal region maintenance/exportin 1/Xpo1 (CRM1) expression in pancreas cancer. Methods: CRM1 was detected, by Western blot, pancreatic tissue from 69 patients and 10 normal subjects. Results: showed increased (P = 0.007). high associated serum levels CEA 0.002) CA19-9 0.005). There an...
Gastric cancer is one of leading causes cancer-related mortality worldwide and a notable disease due to its heterogeneity. Recently, numerous studies have investigated the molecular basis gastric cancer, involving alteration pathogenesis, invasion metastasis. With development modern technologies, various novel biomarkers had been identified that appear possess diagnostic prognostic value; therefore, present review describes our current knowledge for early diagnosis prognosis cancer. Classic...
Cyclooxygenase-2 (COX-2) was stated to be overexpression in various human malignancies associating with angiogenesis, metastasis and chemoresistence. Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease displaying many of these characteristics. A common abnormality PDAC specificity protein-1 (Sp1), which said correlate malignant phenotypes cancers. Using RNA-seq data from The Cancer Genome Atlas (TCGA), we found that Sp1 expression positively correlated COX-2 PDAC, the inhibition or...
The ToGA study showed that trastuzumab plus chemotherapy prolonged median survival in patients with human epidermal growth factor receptor 2 (HER2)-positive advanced gastric cancer. Among options, oxaliplatin might be as effective cisplatin but has shown to more tolerable. To further improve treatment options for cancer, we initiated a evaluate the efficacy and safety of oxaliplatin/capecitabine HER2-positive CGOG1001 was an open-label, multicenter, prospective phase II study. Patients...
Patients with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) have poor outcomes. Gemcitabine + oxaliplatin (GemOx) rituximab, a standard salvage therapy, yields complete response (CR) rates of approximately 30% and median overall survival (OS) 10-13 months. disease fare worse, CR rate 7% for subsequent therapies OS 6 Epcoritamab, CD3xCD20 bispecific antibody approved the treatment R/R DLBCL after ≥2 therapy lines, has shown promising safety efficacy in various...
Abstract Purpose: Angiogenic behavior is a critical aspect of cancer biology and subject to regulation by multiple molecular pathways. Because the signal transducer activator transcription 3 (Stat3) factor regulates genes important angiogenesis, we sought determine whether Stat3 expression related vascular endothelial growth (VEGF) microvessel density (MVD) in gastric these factors predict survival patients. Experimental Design: The VEGF was determined immunohistochemistry using archival...
Abstract Both betulinic acid (BA) and mithramycin A (MIT) exhibit potent antitumor activity through distinct mechanisms of Sp1 inhibition. However, it is unknown whether a combination these two compounds results in synergistic inhibitory effect on pancreatic cancer growth and/or has therapeutic advantage over gemcitabine. In xenograft mouse models human cancer, treatment with either BA or MIT alone showed dose-dependent but led to systemic side effects as measured by overall weight loss....
Abstract The transcription factor Forkhead box M1 (FOXM1) plays important roles in oncogenesis. However, the expression statuses of FOXM1 isoforms and their impact on molecular basis oncogenesis are unknown. We sought to determine identities pancreatic cancer development progression using human tissues, cell lines, animal models. Overexpression mRNA protein was pronounced tumors lines. identified five present cancer: FOXM1a, FOXM1b, FOXM1c along with two tentatively designated as FOXM1b1...
Enhancer of zeste homolog 2 (EZH2) is an essential component the polycomb repressive complex (PRC2), which required for epigenetic silencing target genes, including those affecting cancer progression. Its role in pancreatic remains to be clarified; therefore, we investigated effects aberrantly expressed EZH2 on cancer. We found that expression up-regulated tissues and positively correlated with lymph node metastasis advanced clinical stage patients. knockdown cell lines inhibited migration...
Mithramycin (MIT) and tolfenamic acid (TA) inhibit the activity of transcription factor Sp1. In present study, we investigated whether pancreatic cancer treatment with a combination these compounds has synergistic effect on Sp1 activity, tumor growth, their underlying response mechanisms. Treatment xenografts MIT TA produced dose-dependent antitumor significant either compound alone was directly associated systemic side effects. Combination nontoxic doses both whereas dose lacked discernible...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal primary tumors in humans, with undetermined tumorigenesis. Although previous work by us, and others, has clearly demonstrated an involvement miR-21 growth PDAC, underlying mechanism not been clarified.Here we analyzed regulation FoxO1 vitro vivo, using luciferase-reporter assay pancreatic intraductal infusion antisense miR-21, respectively.We found that overexpression PDAC cells decreased protein levels, whereas inhibition...
The fatality and recurrence rates of bladder cancer (BC) have progressively increased. DNA methylation is an influential regulator associated with gene transcription in the pathogenesis BC. We describe a comprehensive epigenetic study performed to analyse methylation-driven genes BC.Data related methylation, transcriptome survival BC were downloaded from Cancer Genome Atlas (TCGA). MethylMix was used detect BC-specific hyper-/hypo-methylated genes. Metascape carry out ontology (GO)...
Abstract Although previous studies demonstrated that elevated C-reactive protein to albumin ratio (CAR) predicted poor prognosis in various solid tumors, little was known about the prognostic value of CAR patients with advanced pancreatic cancer (APC). The aim present study assess as one independent factor predicting overall survival (OS) APC who had received palliative chemotherapy. Data 142 chemotherapy between 2009 and 2014 were retrospectively documented. We classified into two groups...