A5040264595- Innovative Microfluidic and Catalytic Techniques Innovation
- Metabolomics and Mass Spectrometry Studies
- Electrowetting and Microfluidic Technologies
- Microfluidic and Capillary Electrophoresis Applications
- MicroRNA in disease regulation
- Digital Holography and Microscopy
- Random lasers and scattering media
- Extracellular vesicles in disease
- Nutrition, Genetics, and Disease
- Nanofabrication and Lithography Techniques
- Retinal Diseases and Treatments
- Genetic factors in colorectal cancer
- Genomics and Chromatin Dynamics
- Nanopore and Nanochannel Transport Studies
- Hearing, Cochlea, Tinnitus, Genetics
- Antiplatelet Therapy and Cardiovascular Diseases
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Advanced Fluorescence Microscopy Techniques
- Corneal surgery and disorders
- Colorectal Cancer Screening and Detection
- Nanoplatforms for cancer theranostics
- Genomic variations and chromosomal abnormalities
- Biosensors and Analytical Detection
- Antifungal resistance and susceptibility
Stanford University
2020-2022
STCube (United States)
2022
TechnoServe
2022
OncoPlex Diagnostics (United States)
2020
Tsinghua University
2014-2019
Indiana University School of Medicine
2019
University of Science and Technology of China
2019
Center for Innovation
2019
State Key Laboratory of Membrane Biology
2018
Extracellular vesicles (EVs) are cell-derived nanoscale that provide promising biomarkers for the non-invasive diagnosis of cancer because they carry important cancer-related DNA, RNA and protein biomarkers. However, clinical application EVs is limited by tedious non-standardized isolation methods require bulky instrumentation. Here, we propose an easy-to-operate, simple dielectrophoretic (DEP) method EV with higher recovery efficiency (>83%) purity than ultracentrifugation (UC). The DEP...
Using universal locked nucleic acid probes, a high multiplexing ddPCR-based NIPT was developed to reliably identify fetal aneuploidies.
Background: Markers of aging hold promise in the context colorectal cancer (CRC) care.Utilizing high-resolution metabolomic profiling, we can unveil distinctive age-related patterns that have potential to predict early CRC development.Our study aims unearth a panel markers and delve into alterations associated with CRC.Methods: We assembled serum cohort comprising 5,649 individuals, consisting 3,002 healthy volunteers, 715 patients diagnosed advanced precancerous lesions (APL), 1,932...
Lung cancer is the most common throughout world. Currently, lung therapies are still limited by serious side effects caused. This paper reports a biocompatible drug delivery system that utilizes milk-derived exosomes to deliver paclitaxel treat adenocarcinoma. First, were modified with integrin αVβ₃, αVβ5-binding peptide iRGD so they could successfully target adenocarcinoma cells. Then, loaded (PAC) via electroporation and used for tumor therapy. These proved effective in killing cells,...
Myopia is a prevalent eye disorder, especially among children and adolescents in eastern Asian countries. Multiple measures have already been taken to prevent treat myopia, including atropine dopamine. However, the serum metabolic picture of myopia has not yet studied as whole remains largely unclear. In this paper, prospective panoramic study was carried out find metabolomic lipidomic myopia. With untargeted mass spectrometry (MS), 211 studied. The MS features were first grouped across...
Single-pixel imaging (SPI) exploits the sparsity structure of natural images and enables image acquisition with far fewer measurements than number pixels. However, current SPI devices suffer from low speed an extremely time-consuming reconstruction operation. Photonic time-stretch (PTS) technique is demonstrated to enable high-speed structured-illumination pattern generation, which significantly accelerates conventional devices. Meanwhile, achieve fast reconstruction, phase-shifted...
Hereditary hearing loss is a common clinical neurosensory disorder in humans and has high demand for genetic screening. Current screening techniques using peripheral blood or dried spots (DBSs) are invasive. Therefore, this study aims to develop noninvasive accurate detection method eight hotspot deafness-associated mutations based on buccal swab droplet digital PCR (ddPCR). First, was evaluated analytic performance including specificity, limit, dynamic range plasmid DNA. The specificity...
Droplet digital PCR (ddPCR) is a single-molecule amplification technology with broad applications in precision medicine and clinical diagnosis. Dual-fluorescence four-cluster ddPCR (two/four-ddPCR) assay an effective way to quantify copy numbers. Currently, two/four-ddPCR data are usually classified manual thresholds. For applications, automatic accurate methods required avoid subjectivity Although there some classification algorithms, their accuracy robustness still need be improved meet...
Droplet microfluidics has attracted significant interests in functional microcapsule synthesis, pharmaceuticals, fine chemicals, cosmetics and biomedical research. The low variability of performing chemical reactions inside droplets could benefit from improved homogeneity reproducibility. Therefore, accurate convenient methods are needed to monitor dynamic droplet generation processes. Here, a novel Cosine Similarity Algorithm (CSA) method was developed the frequency accurately rapidly. With...
Micromolding in open capillaries, a simpler method for PDMS through-holes fabrication, whose procedures are easy to handle and observe.
Background: Long-term antiplatelet agents including the potent P2Y12 antagonist ticagrelor are indicated in patients with a previous history of acute coronary syndrome. We sought to compare effect that aspirin monotherapy on vascular endothelial function prior Methods: This was prospective, single center, parallel group, investigator-blinded randomized controlled trial. 200 long-term syndrome 1:1 fashion receive 60 mg BD (n=100) or 100 OD (n=100). The primary end point change from baseline...
Abstract Although genome-wide association studies (GWAS) have identified numerous genetic loci associated with complex diseases, the underlying molecular mechanisms of how these contribute to disease pathogenesis remain largely unknown, due lack an efficient strategy identify risk variants. Here, we proposed a new termed integrated transcriptome and epigenome analysis (iTEA) functional variants in non-coding elements. We considered type 2 diabetes mellitus as model well-known diabetic...
Droplet microfluidics is becoming an enabling technology for synthesizing microscale particles and effective real-time method essential to monitor the variations in a dynamic droplet generation process. Here, novel cosine similarity algorithm (RT-CSA) was developed investigate process by measuring frequency continuously. The RT-CSA uses first-in-first-out (FIFO) vector buffer store calculated similarities, so that these similarities are reused update calculation results once new frame...
206 Background: Human serum metabolome profiles have been analyzed to explore the molecular changes that occur with aging. We hypothesized deep metabolic profiling of sera different ages would allow identification distinct chronologic patterns as a normal biological baseline study personal further assessment this deviation, resulting from advanced precancerous lesion (APL) and stage I/II/III CRC, reference baseline, be instrumental for prognosis relapse revealing underlying pathophysiology....
Single-pixel cameras based on the concepts of compressed sensing (CS) leverage inherent structure images to retrieve them with far fewer measurements and operate efficiently over a significantly broader spectral range than conventional silicon-based cameras. Recently, photonic time-stretch (PTS) technique facilitates emergence high-speed single-pixel A significant breakthrough in imaging speed enables observation fast dynamic phenomena. However, according CS theory, image reconstruction is...
Background: Rhizomucor pusillus Schipper is a very rare and serious opportunistic infection with high mortality. Accurate rapid pathogenic diagnosis critical for early antifungal therapy prognosis. At present, the second‐generation sequencing technology (NGS) can overcome shortcomings of traditional methods, such as long time‐consuming low sensitivity, directly detect pathogens infectious diseases, reports on clinical diseases are gradually increasing. We used NGS to mixed infections...
244 Background: Implementation of population screening for colorectal cancer (CRC) before colonoscopy can reduce the challenge overall capacity bowel examination and improve survival. Blood based CRC assessment biomarkers, on a triage concept, lead to improved selection cost-effective care. Methods: Innovative multi-omics approaches, with global targeted LCMS data production (metabolomics, lipidomics, 2D proteomics) integrative analytics, were applied discover serological biomarkers assess...
e16098 Background: Human serum proteome and metabolome profiles have been analyzed to explore the molecular changes that occur with aging. We hypothesized deep phenomic profiling of longitudinal sera would allow identification distinct chronologic patterns as a normal biological clock baseline study personal further assessment this deviation, due advance adenoma early CRC, from reference ageotypes be instrumental potential diagnostics reveal underlying pathophysiology. Methods: A cohort 7673...
3613 Background: One-third of colorectal cancer (CRC) recurs following curative surgery and chemotherapy. Accordingly, novel methods are needed to predict recurrence enable clinical course mitigating strategies. Serial monitoring plasma by mass spectrometry (MS) multi-omics modeling (MMO) CRC relapse chronology provide the framework for liquid biopsy test development supersede existing imaging modalities such as CT scans according related pathologies. We hypothesized that MS MMO analysis...