A5049404089- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Retinal Diseases and Treatments
- Ophthalmology and Visual Impairment Studies
- Retinal Imaging and Analysis
- Ocular Surface and Contact Lens
- Retinal Development and Disorders
- Ocular Infections and Treatments
- Advanced Fluorescence Microscopy Techniques
- Advanced Proteomics Techniques and Applications
- Intraocular Surgery and Lenses
- Ocular Diseases and Behçet’s Syndrome
- Pain Mechanisms and Treatments
- Retinopathy of Prematurity Studies
- Retinal and Optic Conditions
- Ergonomics and Musculoskeletal Disorders
- Autophagy in Disease and Therapy
Hong Kong Polytechnic University
2022-2025
Tianjin Medical University
2008-2021
Tianjin Medical University Eye Hospital
2008-2021
Background/aims To identify the risk factors for neuropathic corneal pain (NCP) following refractive surgery and to report its clinical manifestations, imaging proteomic characteristics. Methods This 1 year prospective cohort study included 100 eyes that underwent small incision lenticule extraction (SMILE) or laser-assisted in situ keratomileusis (LASIK). Ocular surface assessments, in-vivo confocal microscopy scans, tear neuromediators proteomics analyses were performed. NCP was assessed...
To investigate the tear proteomic and neuromediator profiles, in vivo confocal microscopy (IVCM) imaging features, clinical manifestations neuropathic corneal pain (NCP) patients.
Mice are an emerging model for experimental myopia. Due to their small eye size, non-invasive optical coherence tomography is essential evaluating ocular biometrics. There currently no universally accepted protocol those measurements. This study aims compare biometric measurements using two methods: Purkinje image-based alignment and optic nerve head alignment, utilizing spectral domain tomography. Gaining understanding of the implications these methods in determining axial elongation normal...
Myopia is a prevalent eye disorder, especially among children and adolescents in eastern Asian countries. Multiple measures have already been taken to prevent treat myopia, including atropine dopamine. However, the serum metabolic picture of myopia has not yet studied as whole remains largely unclear. In this paper, prospective panoramic study was carried out find metabolomic lipidomic myopia. With untargeted mass spectrometry (MS), 211 studied. The MS features were first grouped across...
To investigate the lens decentration (LD) of orthokeratology (ortho-k) and association between pretreatment corneal topographic parameters LD ortho-k.Fifty right eyes 50 myopes wearing ortho-k lenses were included in prospective study. Corneal topography was conducted to get parameters, including flat-K (K1); steep-K (K2); astigmatism (CA), CA at 0 3 mm (3 mm-CA), 5 (5 7 (7 mm-CA); surface asymmetry index (SAI); regularity index; curvature best-fit sphere; diameter cornea (DC); distance from...
Purpose: Atropine, a non-selective muscarinic antagonist, effectively slows down myopia progression in human adolescents and several animal models. However, the underlying molecular mechanism is unclear. The current study investigated retinal protein changes of form-deprived myopic (FDM) guinea pigs response to topical administration 1% atropine gel (10 g/L). Methods: At first stage, differentially expressed proteins were screened using fractionated isobaric tags for relative absolute...
To observe and compare the clinical efficacy of 1-year trial fitting software orthokeratology lenses.One hundred myopes who received vision correction with use lenses form July 2016 to September 2017 were included in this study. Subjects assigned randomly into two groups: group (group A) B). For right eye each subject, measurements, such as uncorrected visual acuity (UCVA, logarithm minimal angle resolution), refractive error, corneal topography, ocular health status, situation, obtained at...
Uveitis is a group of sight-threatening ocular inflammatory diseases, potentially leading to permanent vision loss in patients. However, it remains largely unknown how uveitis causes retinal malfunction and loss. Endotoxin-induced (EIU) rodents good animal model study associated acute inflammation. To understand the pathogenic mechanism screen potential targets for treatment, we analyzed proteomic profile EIU mouse using data-independent acquisition-based mass spectrometry (SWATH-MS). After...
Age-related macular degeneration (AMD) is a degenerative eye disease leading to central vision loss and characterized by dysregulated autophagy of the retinal pigment epithelium (RPE) layer. Recent studies have suggested that rho-associated protein kinase (ROCK) inhibitors may enhance in neurodegenerative diseases promote survival RPE cells. This study investigated effect ROCK on gene expression autophagic vacuole formation human (ARPE-19) cell line. The highly selective potent inhibitor...
Atropine, a non-selective muscarinic antagonist, is known to slow down myopia progression in human adolescents and several animal models. However, its underlying molecular mechanism unclear. The present work built monocular form-deprivation (FDM) guinea pig model, using facemasks as well atropine treatment on FDM eyes for 2 4 weeks. Retinal protein changes response the effects of topical administration were screened two periods fractionated isobaric tags relative absolute quantification...
Abstract Background Myopia is the leading cause of distance refractive error, in which objects form front retina rather than on itself during emmetropization. Mice an emerging model for experimental myopia. This study aims to compare ocular biometric measurements with Purkinje image-based and optic nerve head alignment methods normal eyes C57BL/6J mice. Methods Ocular dimensions development were measured postnatal days P21 (n = 10), P28 15), P35 8). The (P1) was determined by a...
Objective To explore the distribution of choroidal thickness and its influence factors in university students. Methods A cross-sectional study. A total 896 eyes college students were included Among them, there 350 males (350 eyes) 546 females (546 eyes). All right eyes. The average age was 19.18 ± 1.36 years old. According to spherical equivalent refraction (SER), divided into non-myopia group, low myopia moderate group high which 59, 251, 356 230 eyes, respectively. subfoveal ChT...