A5007845498- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Microscopic Colitis
- Colorectal Cancer Treatments and Studies
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Single-cell and spatial transcriptomics
- Colorectal Cancer Surgical Treatments
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Research and Treatments
- Multiple Myeloma Research and Treatments
- Glioma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Lung Cancer Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Cancer, Lipids, and Metabolism
- Lymphoma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Esophageal Cancer Research and Treatment
- Cancer Mechanisms and Therapy
Indiana University Health
2023-2025
Indiana University Bloomington
2025
Indiana University – Purdue University Indianapolis
2022-2025
Indiana University School of Medicine
2022-2025
Indiana University Melvin and Bren Simon Comprehensive Cancer Center
2023-2025
Indiana University
2023-2024
University of Indianapolis
2023-2024
Indiana University Indianapolis
2023
Indiana Cancer Consortium
2023
University School
2023
Although human LINE-1 (L1) elements are actively mobilized in many cancers, a role for somatic L1 retrotransposition tumor initiation has not been conclusively demonstrated. Here, we identify novel insertion the APC suppressor gene that provided us with unique opportunity to determine whether such insertions can actually initiate colorectal cancer (CRC), and if so, how this might occur. Our data support model whereby hot source element on Chromosome 17 of patient's genome evaded repression...
The survival benefit with adjuvant chemotherapy for patients resected stage II-III non-small-cell lung cancer (NSCLC) is modest. Efforts to develop prognostic or predictive biomarkers in these have not yielded clinically useful tests. We report findings from the Lung Adjuvant Cisplatin Evaluation (LACE)-Bio-II study, which we analyzed next-generation sequencing and long-term outcomes data > 900 early-stage NSCLC treated prospectively landmark clinical trials. used a targeted gene panel...
Colorectal cancer (CRC) consensus molecular subtypes (CMS) have different immunological, stromal cell, and clinicopathological characteristics. Single-cell characterization of CMS subtype tumor microenvironments is required to elucidate mechanisms stroma cell contributions pathogenesis which may advance subtype-specific therapeutic development. We interrogate racially diverse human CRC samples analyze multiple independent external cohorts for a total 487,829 single cells enabling...
Nearly all patients with small cell lung cancer (SCLC) eventually relapse chemoresistant disease. The molecular mechanisms driving chemoresistance in SCLC remain un-characterized. Here, we describe whole-exome sequencing of paired tumor samples procured at diagnosis and from 12 patients, unpaired 18 additional patients. Multiple somatic copy number alterations, including gains ABCC1 deletions MYCL, MSH2, MSH6, are identifiable relapsed samples. Relapse also exhibit recurrent mutations loss...
Patient-derived tumor organoids (TOs) are emerging as high-fidelity models to study cancer biology and develop novel precision medicine therapeutics. However, utilizing TOs for systems-biology-based approaches has been limited by a lack of scalable reproducible methods profile these models. We describe robust pan-cancer TO platform with chemically defined media optimized on cultures acquired from over 1,000 patients. Crucially, we demonstrate genetic transcriptomic concordance this approach...
Ampullary cancers refer to tumors originating from the ampulla of Vater (the ampulla, intraduodenal portion bile duct, and pancreatic duct), while periampullary may arise locations encompassing head pancreas, distal duodenum, or Vater. are rare gastrointestinal malignancies, prognosis varies greatly based on factors such as patient age, TNM classification, differentiation grade, treatment modality received. Systemic therapy is used in all stages ampullary cancer, including neoadjuvant...
Abstract Numerous cell states are known to comprise the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME). However, developmental stemness and co-occurrence of these remain poorly defined. Here, we performed single-cell RNA sequencing (scRNA-seq) on a cohort treatment-naive PDAC time-of-diagnosis endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) samples ( n = 25). We then combined with surgical resection 6) publicly available increase statistical power 80)....
587 Background: Patient survival is impacted by several factors, one of which stage at diagnosis. From 1976 to 2014, CRC death rate in the United States (US) declined 51%. This retrospective study was conducted using US Surveillance, Epidemiology and End Results (SEER) data evaluate 1- 5-year relative for patients with American Joint Committee on Cancer (AJCC) stage, age sex Methods: The included adults (age ≥20 years) SEER-18 registry diagnosed 2004-2014. One- rates were stratified AJCC...
PURPOSE Approximately 10%-40% of patients with lung cancer report no history tobacco smoking (never-smokers). We analyzed whole-exome and RNA-sequencing data 160 tumor normal adenocarcinoma (LUAD) samples from never-smokers to identify clinically actionable alterations gain insight into the environmental hereditary risk factors for LUAD among never-smokers. METHODS performed 88 69 never-smoker LUADs. these in conjunction 76 299 smoker sequenced by The Cancer Genome Atlas Clinical Proteomic...
Primary non-Hodgkin lymphoma (NHL) of liver is a very rare malignancy. Here, we report the case 65-year-old man who presented with constipation and right groin pain 2 months' duration. A computed tomography (CT) scan abdomen incidentally detected multiple hypodense nodules in both lobes liver. Diagnosis primary NHL was made using ultrasound-guided biopsy. Extensive investigations--which included bone marrow biopsy; fluorescence situ hybridization; flow cytometry; CT chest, abdomen, pelvis;...
Cancer chemoprevention is defined as the use of natural agents to suppress, reverse or prevent carcinogenic process from turning into aggressive cancer. Over last two decades, multiple dietary compounds with diverse chemical structures such flavonoids, tannins, curcumins and polyphenols have been proposed chemopreventive agents. These proven excellent anticancer potential in laboratory setting, however, observed effects vitro do not translate clinic where they fail live up their...
Tumor heterogeneity, especially intratumoral is a primary reason for treatment failure. A single biopsy may not reflect the complete genomic architecture of tumor needed to make therapeutic decisions. Circulating DNA (ctDNA) believed overcome these limitations. We analyzed concordance between ctDNA and whole-exome sequencing/whole-genome sequencing (WES/WGS) samples from patients with breast (n = 12), gastrointestinal 20), lung 19), other types 13). Correlation in driver, hotspot, actionable...
Abstract Epithelial mesenchymal transition (EMT) describes a process by which the epithelial cells acquire properties associated with increased migration, invasion, and resistance to therapy. Targeting intercellular communications molecular changes that enable EMT is rational therapeutic approach in PDAC. Our group has previously reported on KPC-Luc PDAC orthotopic mouse models treated 1. Sham, 2. paricalcitol plus hydroxychloroquine (PH), 3. gemcitabine (G), 4. GPH. Single cell RNA sequence...
Abstract Background BRAF activating mutations occur in approximately 10% of metastatic colorectal cancer (CRCs) and are associated with worse prognosis part due to an inferior response standard chemotherapy. Standard care for patients refractory V600E CRC is treatment EGFR inhibitors recent FDA approval was given use these combination chemotherapy naïve CRC. Lineage plasticity neuroendocrine emerging mechanism targeted therapy resistance several types. Enteroendocrine cells (EECs), the cell...
Pancreatic cancer (PC) has a complex etiology and displays wide range of cellular escape pathways that allow it to resist different treatment modalities. Crucial signaling molecules function downstream the survival pathways, particularly at points where several these crosstalk, provide valuable targets for development novel anti-cancer drugs. Bcl-2 family member proteins are anti-apoptotic known be overexpressed in most cancers including PC. The machinery been linked observed resistance...