A5059174975- Pancreatic and Hepatic Oncology Research
- Caveolin-1 and cellular processes
- Cancer Treatment and Pharmacology
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- Vibrio bacteria research studies
- Trace Elements in Health
- Heat shock proteins research
- Protein Structure and Dynamics
- Mass Spectrometry Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Immunotherapy and Immune Responses
- Erythrocyte Function and Pathophysiology
- Alzheimer's disease research and treatments
- Nutrition, Genetics, and Disease
- Cerebrospinal fluid and hydrocephalus
- Viral-associated cancers and disorders
- Cystic Fibrosis Research Advances
- Autophagy in Disease and Therapy
- BRCA gene mutations in cancer
- Lymphoma Diagnosis and Treatment
University of Toledo
2024
University of Toledo Medical Center
2023
The Ohio State University
2021-2022
The Ohio State University Wexner Medical Center
2020
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2019-2020
CancerCare
2009
Autophagy is a proposed route of amyloid-β (Aβ) clearance by microglia that halted in Alzheimer's Disease (AD), though mechanisms underlying this dysfunction remain elusive. Here, primary from adult AD (5xFAD) mice were utilized to demonstrate 5xFAD fail degrade Aβ and express low levels autophagy cargo receptor NBR1. In mouse brains, we show for the first time elevated microRNA cluster Mirc1/Mir17-92a, which known downregulate proteins. By situ hybridization post-mortem human tissue...
Primary non-Hodgkin lymphoma (NHL) of liver is a very rare malignancy. Here, we report the case 65-year-old man who presented with constipation and right groin pain 2 months' duration. A computed tomography (CT) scan abdomen incidentally detected multiple hypodense nodules in both lobes liver. Diagnosis primary NHL was made using ultrasound-guided biopsy. Extensive investigations--which included bone marrow biopsy; fluorescence situ hybridization; flow cytometry; CT chest, abdomen, pelvis;...
Cystic fibrosis (CF) human and mouse macrophages are defective in their ability to clear bacteria such as
In recent years, human serum albumin (HSA) has been characterized as an ideal drug carrier in the cancer arena. Caveolin-1 (Cav-1) established principal structural protein of caveolae and, thus, critical for caveolae-mediated endocytosis. Cav-1 shown to be overexpressed cancers lung and pancreas, among others. We found that expression plays a role both HSA uptake response albumin-based chemotherapies. As such, developing novel chemotherapy is more selective tumors with high or levels...
Copper is crucial for many physiological processes across mammalian cells, including energy metabolism, neurotransmitter synthesis, and antioxidant defense mechanisms. However, excessive copper levels can lead to cellular toxicity "cuproptosis", a form of programmed cell death characterized by the accumulation within mitochondria. Tumor cells are less sensitive this than normal mechanism which remains unclear. We address important issue exploring role heat shock factor 1 (HSF1),...
Concurrent gemcitabine and nab-paclitaxel treatment is one of the preferred chemotherapy regimens for metastatic locally advanced pancreatic ductal adenocarcinoma (PDAC). Previous studies demonstrate that caveolin-1 (Cav-1) expression critical uptake into tumors correlates with response. Gemcitabine increases by increasing Cav-1 expression. Thus, we hypothesized pretreatment would further enhance sensitivity PDAC to uptake.
Abstract Introduction: Gemcitabine (gem) and Abraxane (albumin-bound paclitaxel, abx) combination chemotherapy delivered on the same day is now one of preferred regimens for metastatic locally advanced pancreatic ductal adenocarcinoma (PDAC) based results phase III MPACT clinical trial that showed improved overall survival gem+abx compared to gem alone in metastatic/advanced setting. Our previous published works revealed caveolin-1 (Cav-1), principal structural component caveolae mediator...