A5024952811- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Mechanical Circulatory Support Devices
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Transplantation: Methods and Outcomes
- Cardiac pacing and defibrillation studies
- Airway Management and Intubation Techniques
- Tracheal and airway disorders
- Infectious Aortic and Vascular Conditions
- Cardiac Arrhythmias and Treatments
- Infective Endocarditis Diagnosis and Management
- COVID-19 Clinical Research Studies
- Hemodynamic Monitoring and Therapy
- Glaucoma and retinal disorders
- Ultrasound in Clinical Applications
- Cardiac and Coronary Surgery Techniques
- MicroRNA in disease regulation
- Spinal Cord Injury Research
- SARS-CoV-2 and COVID-19 Research
- Nausea and vomiting management
- Intraoperative Neuromonitoring and Anesthetic Effects
- Pericarditis and Cardiac Tamponade
The Ohio State University Wexner Medical Center
2016-2025
The Ohio State University
2012-2024
University of Rochester
2023-2024
Al-Azhar University
2023
Jamaica Hospital
2021
SUNY Upstate Medical University
2020
Neurological Surgery
2016
RWTH Aachen University
2012
Cleveland Clinic
2000
BACKGROUND: Intraocular pressure (IOP) increases in steep Trendelenburg positioning, but the magnitude of increase has not been quantified. In addition, factors contributing to this have studied robot-assisted prostatectomy cases. study, we sought quantify changes IOP and examine perioperative responsible for these while patients are position during robotic prostatectomy. METHODS: prospective measured using a Tono-pen® XL 33 undergoing The was before anesthesia supine awake (baseline T1),...
Brain inflammation plays a central role in multiple sclerosis (MS). Besides lymphocytes, the astroglia and microglia mainly contribute to cellular composition of inflammatory infiltrate MS lesions. Several studies were able demonstrate that cortical lesions are characterized by lower levels cells among activated microglia/macrophages. The underlying mechanisms for this difference, however, remain be clarified. In current study, we compared kinetics extent astrocyte activation during early...
Autophagy is a proposed route of amyloid-β (Aβ) clearance by microglia that halted in Alzheimer's Disease (AD), though mechanisms underlying this dysfunction remain elusive. Here, primary from adult AD (5xFAD) mice were utilized to demonstrate 5xFAD fail degrade Aβ and express low levels autophagy cargo receptor NBR1. In mouse brains, we show for the first time elevated microRNA cluster Mirc1/Mir17-92a, which known downregulate proteins. By situ hybridization post-mortem human tissue...
// Esmerina Tili 1,2,* , Marcela Chiabai 2,* Dario Palmieri Melissa Brown 2 Ri Cui Cecilia Fernandes Tim Richmond Taewan Kim 3 Tyler Sheetz Hui-Lung Sun Alessandro Lagana 4 Veneziano Stefano Volinia 5 Laura Rassenti 6 Thomas Kipps Hamdy Awad 1 Jean-Jacques Michaille 2,7 and Carlo M. Croce Department of Anesthesiology, Wexner Medical Center, The Ohio State University, Columbus, OH, USA Molecular Virology, Immunology Genetics, Center Comprehensive Cancer Cellular Oncology, University Texas MD...
Background Three types of opioid receptors, mu, delta, and kappa, are present in the periphery central nervous system. In contrast to effects system, antinociceptive action opioids is not as well characterized. The intraarticular, spinal, intramuscular injections kappa agonists on autonomic response evoked by compression an inflamed knee joint were evaluated. Methods halothane-anesthetized rats, arthritis was induced injecting kaolin carrageenan into right joint. Standardized inflation a...
Background Spinal cord ischemia and paralysis are devastating perioperative complications that can accompany open or endovascular repair surgery for aortic aneurysms. Here, we report on the development of a new mouse model spinal with delayed induced by cross-clamping descending aorta. Methods Transient occlusion was produced in mice aorta through lateral thoracotomy. To establish an optimal surgical procedure limited mortality, variable cross-clamp times core temperatures were tested...
Management of deep sternal wound infection (SWI), a serious complication after cardiac surgery with high morbidity and mortality incidence, requires invasive procedures such as, debridement primary closure or myocutaneous flap reconstruction along use broad spectrum antibiotics. The purpose this clinical series is to investigate the presence biofilm in patients SWI. A complex microbial community which bacteria attach biological non-biological surface are embedded self-produced extracellular...
Abstract We present a case in which patient with previous sternotomy and left ventricular assist device (LVAD) implantation developed cardiac arrest during resternotomy for LVAD exchange. The surgeon refused chest compressions fear of potential damage to the inflow cannula directly beneath sternum. perioperative team had no alternatives external massage other than rapid deployment extra-corporeal membrane oxygenation mechanical support, so anesthesiologist advised nursing personnel perform...
THE literature on anesthetic concerns and perioperative care of patients with mediastinal masses has focused almost exclusively anterior masses. Posterior traditionally have been suggested to carry a low risk implications.1We present the case patient posterior mass who experienced hemodynamic respiratory decompensation upon induction general anesthesia required urgent transition cardiopulmonary bypass (CPB).Our illustrates importance real-time imaging provided by transesophageal...
Background Postoperative pain management is a critical aspect of patient care. The inflammatory state the post-sternotomy surgical wound sensitizes nerve endings, causing pain. Unrelieved or improperly managed compromises healing. Peripheral opioid receptors play major role in analgesia, particularly under conditions where both receptor expression and efficacy are increased. Leukocytic peptides include β-endorphin (END), met-enkephalin (ENK), dynorphin-A (DYN), with END ENK being...