A5100329535- Alzheimer's disease research and treatments
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Cellular transport and secretion
- Cholinesterase and Neurodegenerative Diseases
- Phytochemicals and Antioxidant Activities
- RNA Research and Splicing
- Endoplasmic Reticulum Stress and Disease
- Mycobacterium research and diagnosis
- Diverse Approaches in Healthcare and Education Studies
- Glycosylation and Glycoproteins Research
- Neuroscience and Neuropharmacology Research
- Diverse Topics in Contemporary Research
- Healthcare and Venom Research
- Asthma and respiratory diseases
- 14-3-3 protein interactions
- Ecology and Conservation Studies
- Cancer Immunotherapy and Biomarkers
- RNA and protein synthesis mechanisms
- RNA regulation and disease
- Dermatology and Skin Diseases
- Plant-Microbe Interactions and Immunity
- Adipokines, Inflammation, and Metabolic Diseases
The Ohio State University
2011-2025
Andong National University
2010-2025
Soonchunhyang University
2020-2025
Sejong University
2024
Korea Food Research Institute
2020-2024
Hanmi Pharmaceutical (South Korea)
2021-2024
Columbia University
2001-2023
Shenzhen University Health Science Center
2020-2023
Shenzhen University
2022-2023
Hanyang University
2023
Abstract Extracellular interaction between programmed death ligand-1 (PD-L1) and cell protein-1 (PD-1) leads to tumour-associated immune escape. Here we show that the immunosuppression activity of PD-L1 is stringently modulated by ubiquitination N -glycosylation. We glycogen synthase kinase 3β (GSK3β) interacts with induces phosphorylation-dependent proteasome degradation β-TrCP. In-depth analysis N192, N200 N219 glycosylation suggests antagonizes GSK3β binding. In this regard, only...
p53 suppresses tumor progression and metastasis. Epithelial–mesenchymal transition (EMT) is a key process in The transcription factors ZEB1 ZEB2 promote EMT. Here, we show that EMT by repressing expression of ZEB2. By profiling 92 primary hepatocellular carcinomas (HCCs) 9 HCC cell lines, found up-regulates microRNAs (miRNAs), including miR-200 miR-192 family members. members transactivated then repress ZEB1/2 expression. p53-regulated also Inhibition or overexpression the miRNAs affects...
Zinc is an essential trace element required for bone formation, however not much has been clarified yet its role in osteoblast. We hypothesized that zinc would increase osteogenetic function osteoblasts. To test this, we investigated whether treatment enhances formation by stimulating osteoblast proliferation, marker protein alkaline phosphatase activity and collagen synthesis osteoblastic MC3T3-E1 cells. cells were cultured treated with various concentrations of (0, 1, 3, 15, 25 uM) along a...
Most cases of early-onset familial Alzheimer's disease (FAD) are caused by mutations in the genes encoding presenilin 1 (PS1) and PS2 proteins, both which undergo regulated endoproteolytic processing. During apoptosis, PS1 were shown to be cleaved at sites distal their normal cleavage a caspase-3 family protease. In cells expressing containing asparagine-141 FAD mutant, ratio alternative fragments was increased relative wild-type PS2-expressing cells, suggesting potential role for...
Mutations in the presenilin genes, PS1 and PS2, cause a major portion of early onset familial Alzheimer's disease (FAD). The biological roles presenilins how their pathological mutations confer FAD are unknown. In this study, we set out to examine processing degradation pathways PS2. For regulated expression have established inducible cell lines expressing PS2 under tight control tetracycline-responsive transactivator. Western blot analysis revealed that was detected as an ∼53-55-kDa...
A novel and highly conserved presynaptic protein has been independently described in rodents (synuclein/SYN-1), songbirds (synelfin), humans (the precursor of the non-A beta component senile plaques, NACP); a fragment latter detected plaques Alzheimer's disease (AD). We characterized expression NACP human AD non-AD brain. subcellular fractionation study demonstrated that was mainly localized to cytosolic fractions temporal cortex. also detectable various membrane vesicular fractions,...
The mechanism by which the 8q24 MYC enhancer region, including cancer-associated variant rs6983267, increases cancer risk is unknown due to lack of protein-coding genes at 8q24.21. Here we report identification long noncoding RNAs named region (CARLos) in region. expression one RNAs, CARLo-5, significantly correlated with rs6983267 allele associated increased susceptibility. We also found physically interacts active regulatory CARLo-5 promoter, suggesting long-range interaction promoter...
Growing evidence implicates aberrant lipid signaling in Alzheimer's disease (AD). While phospholipases A2 and C have been recently shown to mediate key actions of amyloid β-peptide (Aβ) through a dysregulation arachidonic acid phosphatidylinositol-4,5-bisphosphate metabolism, respectively, the role phospholipase D (PLD) has so far remained elusive. PLD produces phosphatidic (PA), bioactive involved multiple aspects cell physiology, including membrane trafficking processes. Here we show that...
MicroRNAs (miRNAs) are small 19- to 24-nt noncoding RNAs that have the capacity regulate fundamental biological processes essential for cancer initiation and progression. In cancer, miRNAs may function as oncogenes or tumor suppressors. Here, we conducted global profiling in a cohort of stage 1 nonsmall cell lung cancers ( n = 81) determined miR-486 was most down-regulated miRNA tumors compared with adjacent uninvolved tissues, suggesting loss be important development. We report directly...
MicroRNAs (miRNAs) are increasingly implicated in regulating cancer initiation and progression. In this study, two miRNAs, miR-25 -32, identified as p53-repressed miRNAs by p53-dependent negative regulation of their transcriptional regulators, E2F1 MYC. However, -32 result p53 accumulation directly targeting Mdm2 TSC1, which regulators the mTOR (mammalian target rapamycin) pathway, respectively, leading to inhibition cellular proliferation through cell cycle arrest. Thus, there is a...
The functions of long noncoding RNAs (lncRNAs) have been identified in several cancers, but the roles lncRNAs colorectal cancer (CRC) are less well understood. transcription factor MYC is known to regulate and has implicated cell proliferation tumorigenesis.CRC cells tissues were profiled identify differentially expressed CRC, from which we further selected MYC-regulated lncRNAs. We used luciferase promoter assay, ChIP, RNA pull-down deletion mapping LC-MS/MS immunoprecipitation determine...
Significance Aberrant microRNA (miRNA) expression is involved in tumorigenesis, and miR-224 was observed to be up-regulated certain tumor types. However, the role of pathogenesis lung cancer remains poorly understood. Here, we comprehensively analyzed revealed mechanisms up-regulation its oncogenic nonsmall cell (NSCLC). We showed that promotes cellular migratory, invasive, proliferative capacity growth both vitro vivo. Furthermore, identified TNFα-induced protein 1 SMAD4 as targets . In...
Highlights•ERK phosphorylation followed by Pin1-mediated isomerization impairs XPO5 activity•Downregulation of miR-122 leads to taxol resistance through septin-9 and MARK4•XPO5 correlates with poor prognosis in HCC patients•Pin1 MARK4 are potential targets for clinical intervention liver cancerSummaryMicroRNAs (miRNA) mostly downregulated cancer. However, the mechanism underlying this phenomenon precise consequence tumorigenesis remain obscure. Here we show that ERK suppresses pre-miRNA...
We conducted genome-wide miRNA-sequencing (miRNA-seq) in primary cancer tissue from patients of lung adenocarcinoma to identify markers for the presence lymph node metastasis.Markers metastasis identified by sequencing were validated a separate cohort using quantitative PCR. After additional validation The Cancer Genome Atlas (TCGA) dataset, functional characterization studies vitro.MiR-31 was upregulated tissues with metastases compared those without metastases. confirmed miR-31 be...
Abstract Arginine methylation is an important posttranslational modification catalyzed by protein arginine methyltransferases (PRMTs). However, the role of PRMTs in colorectal cancer (CRC) progression not well understood. Here we report that non-POU domain-containing octamer-binding (NONO) overexpressed CRC tissue and a potential marker for poor prognosis patients. NONO silencing resulted decreased proliferation, migration, invasion cells, whereas overexpression had opposite effect. In...
Phosphatidylinositol 4,5-bisphosphate (PIP2) is an important cellular effector whose functions include the regulation of ion channels and membrane trafficking. Aberrant PIP2 metabolism has also been implicated in a variety human disease states, e.g., cancer diabetes. Here we report that familial Alzheimer's (FAD)-associated presenilin mutations cause imbalance metabolism. We find transient receptor potential melastatin 7 (TRPM7)-associated Mg2+ -inhibited cation (MIC) channel underlies...
BACE1 (β-site β-amyloid precursor protein (APP)-cleaving enzyme 1) mediates the first proteolytic cleavage of APP, leading to amyloid β-peptide (Aβ) production. It has been reported that intracellular trafficking, in particular endosome-to-TGN sorting, is mediated by adaptor complexes, such as retromer and Golgi-localized γ-ear-containing ARF-binding proteins (GGAs). Here we investigated whether sortilin, a Vps10p domain-sorting receptor believed participate retromer-mediated transport...