A5048833151- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Cardiovascular Conditions and Treatments
- Ion channel regulation and function
- Cardiac Ischemia and Reperfusion
- Heart Rate Variability and Autonomic Control
- Cardiac pacing and defibrillation studies
- Cardiac Arrest and Resuscitation
- Cardiomyopathy and Myosin Studies
- ECG Monitoring and Analysis
- Cardiovascular Effects of Exercise
- Cardiac Imaging and Diagnostics
- Hemodynamic Monitoring and Therapy
- Mechanical Circulatory Support Devices
- Receptor Mechanisms and Signaling
- Veterinary Pharmacology and Anesthesia
- Pharmacological Effects and Assays
- Cardiovascular and exercise physiology
- Atrial Fibrillation Management and Outcomes
- Cardiac Valve Diseases and Treatments
- Veterinary Equine Medical Research
- Advanced MRI Techniques and Applications
- Cardiovascular Disease and Adiposity
- Heart Failure Treatment and Management
Stanford University
2024
The Ohio State University
2014-2023
QED Labs
2013-2022
Regeneron (United States)
2020
AbbVie (United States)
2016
Lung Institute
2007-2013
PhaseBio Pharmaceuticals (United States)
2013
University of Minnesota
2011
VivaQuant (United States)
2011
Battelle
2008
This is the report of American College Veterinary Internal Medicine (ACVIM) Specialty Cardiology consensus panel convened to formulate guidelines for diagnosis and treatment chronic valvular heart disease (CVHD, also known as endocardiosis myxomatous valve degeneration) in dogs. It estimated that approximately 10% dogs presented primary care veterinary practices have disease, CVHD most common many parts world, accounting 75% canine cases seen by North America. commonly affects left...
Atrial fibrillation (AF), the most common chronic arrhythmia, increases risk of stroke and is an independent predictor mortality. Available pharmacological treatments have limited efficacy. Once initiated, AF tends to self-perpetuate, owing in part electrophysiological remodeling atria; however, fundamental mechanisms underlying this process are still unclear. We recently demonstrated that human associated with increased atrial oxidative stress peroxynitrite formation; we now tested...
Patients with refractory hypercholesterolemia, who have high low-density lipoprotein (LDL) cholesterol levels despite treatment lipid-lowering therapies at maximum tolerated doses, an increased risk of atherosclerosis. In such patients, the efficacy and safety subcutaneous intravenous evinacumab, a fully human monoclonal antibody against angiopoietin-like 3, are not known.In this double-blind, placebo-controlled, phase 2 trial, we enrolled patients or without heterozygous familial...
Although epinephrine has been shown to improve myocardial blood flow during cardiopulmonary resuscitation (CPR), the effects of standard as well larger doses on regional have not examined. In this study we compared various after a 10 min arrest in swine preparation. Fifteen weighing greater than 15 kg each were instrumented for measurements with tracer microspheres. Regional was measured normal sinus rhythm. After ventricular fibrillation, CPR begun and determined. Animals then randomly...
The purpose of this study was to correlate the exercise-induced changes oxidant stress enzymes with possible modification response putative stressor doxorubicin. Enzymatic and histological were studied in mice placed on a 21-wk swim training program (1 h/day, 5 days/wk) without anthracycline administration. Doxorubicin (4 mg/kg) administered intravenously through tail vein 10 separate days over 7-wk period (twice weekly during weeks 10, 11, 14, 15, 16). Blood, liver, heart levels catalase...
Diminished Ca release from the sarcoplasmic reticulum (SR) is an important contributor to impaired contractility of failing heart. Despite extensive effort, underlying causes abnormal SR in heart failure (HF) remain unknown. We used a combination simultaneous imaging cytosolic and intraluminal [Ca] isolated cardiomyocytes recordings single-ryanodine receptor (RyR) channels reconstituted into lipid bilayers investigate alterations intracellular handling experimental model chronic HF. found...
In heart failure (HF), abnormal myocyte Ca2+ handling has been implicated in cardiac arrhythmias and contractile dysfunction. the present study, we investigated relationships between handling, reduced contractility, enhanced arrhythmogenesis during HF progression a canine model of non-ischaemic HF. Key parameters were determined by measuring cytosolic intra-sarcoplasmic reticulum (SR) [Ca2+] isolated ventricular myocytes at different stages The was associated with an early continuous...
Background Failing human hearts lose β 1 - but not 2 -adrenergic receptors. In canine with tachypacing failure, the ratio of to receptors is increased. The present study was designed determine whether heart failure increases sensitivity stimulation in isolated ventricular cardiomyocytes and verify that myocytes from failing ventricles contain functional Methods Results Myocytes healthy dogs, dogs transplant recipients were loaded fura 2-AM subjected electric field presence zinterol, a highly...
Atrial fibrillation (AF) is characterized by decreased L-type calcium current (I(Ca,L)) in atrial myocytes and contractility. Oxidant stress redox modulation of channels are implicated these pathologic changes. We evaluated the relationship between glutathione content (the primary cellular reducing moiety) I(Ca,L) specimens from AF patients undergoing cardiac surgery. Left was significantly lower with either paroxysmal or persistent relative to control no history AF. Incubation (but not...
We recently showed that Bendavia, a novel mitochondria-targeting peptide, reduced infarction and no-reflow across several experimental models. The purpose of this study was to determine the therapeutic timing mechanism action underlie Bendavia’s cytoprotective property. In rabbits exposed in vivo ischemia/reperfusion (30/180 min), Bendavia administered 20 minutes prior reperfusion (0.05 mg/kg/h, intravenously) myocardial infarct size by ∼50% when for either 1 or 3 hours reperfusion. However,...
Diabetic heart disease is a distinct clinical entity that can progress to failure and sudden death. However, the mechanisms responsible for alterations in excitation-contraction coupling leading cardiac dysfunction during diabetes are not well known. Hyperglycemia, landmark of diabetes, leads formation advanced glycation end products (AGE) on long-lived proteins, including SR Ca2+ regulatory proteins. their pathogenic role handling myocytes unknown. Therefore, we investigated whether an AGE...
Blood velocity measurements were carried out using a constant-temperature hot-film anemometer system in both anesthetized and conscious horses. Catheter probes used to measure wave forms horses L-shaped needle inserted by direct vessel puncture the profiles regions of thoracic abdominal aorta anesthetized, open-chest Both catheter for coronary wave-form measurements. The flow conditions characterized peak Reynolds numbers 200-10,000 unsteadiness parameter 2-30. These indicate that at systole...
AimsWe sought to define the underlying mechanisms for atrial fibrillation (AF) during chronic heart failure (HF).
Abstract Objective —To evaluate the use of 24-hour ambulatory electrocardiography (AECG) for detection ventricular premature complexes (VPC) in healthy dogs. Design —Case series. Animals —50 mature Procedure —A AECG was performed on each dog and evaluated presence VPC. Results —Fifty dogs weighing between 18.2 to 40.9 kg (40 90 lb) representing 13 breeds were evaluated; there 4 sexually intact females, 21 spayed males, castrated males. Ages ranged from 1 12 years. Thirty-four had no VPC; 16...
Abstract Objective —To evaluate the effect of 4 antiarrhythmic treatment protocols on number ventricular premature complexes (VPC), severity arrhythmia, heart rate (HR), and syncopal episodes in Boxers with tachyarrhythmias. Design —Randomized controlled clinical trial. Animals —49 Boxers. Procedure —Dogs > 500 VPC/24 h via 24-hour ambulatory ECG (AECG) were treated atenolol (n = 11), procainamide (11), sotalol (16), or mexiletine (11) for 21 to 28 days. Results pre- posttreatment AECG...
ABSTRACT Heart rate variability was measured in 81 Cavalier King Charles spaniels to investigate if it could be used evaluate the severity of mitral regurgitation and predict decompensation. assessed by natural logarithm variance R‐R intervals for 20 consecutive beats obtained from electrocardiographic recordings. Twenty‐two dogs were clinically normal 59 had caused chronic valvular disease. The evaluated echocardiography thoracic radiography. found reduced (P < 0.001) among with severe...