A5052549046- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Adipose Tissue and Metabolism
- Cardiovascular and exercise physiology
- Cardiovascular Effects of Exercise
- Mesenchymal stem cell research
- Pharmacological Effects and Assays
- Heart Rate Variability and Autonomic Control
- Congenital Heart Disease Studies
- Tissue Engineering and Regenerative Medicine
- Liver Disease Diagnosis and Treatment
- Electrospun Nanofibers in Biomedical Applications
- Receptor Mechanisms and Signaling
- Cardiac Valve Diseases and Treatments
- Thermoregulation and physiological responses
- Alcohol Consumption and Health Effects
- Cardiac pacing and defibrillation studies
- Ion channel regulation and function
- Anesthesia and Neurotoxicity Research
- Spinal Cord Injury Research
- Autophagy in Disease and Therapy
- Tendon Structure and Treatment
- Muscle metabolism and nutrition
- Total Knee Arthroplasty Outcomes
Universidade Federal de Viçosa
2012-2021
Universidade Federal dos Vales do Jequitinhonha e Mucuri
2019
Instituto Federal de Educação, Ciência e Tecnologia de Minas Gerais
2019
Hospital Universitário da Universidade de São Paulo
2018
Zoetis (United States)
2016
Université Libre de Bruxelles
2010
Hospital de Santo António
2008
The Ohio State University
2006-2007
Centro de Estudios Científicos
2005
Diminished Ca release from the sarcoplasmic reticulum (SR) is an important contributor to impaired contractility of failing heart. Despite extensive effort, underlying causes abnormal SR in heart failure (HF) remain unknown. We used a combination simultaneous imaging cytosolic and intraluminal [Ca] isolated cardiomyocytes recordings single-ryanodine receptor (RyR) channels reconstituted into lipid bilayers investigate alterations intracellular handling experimental model chronic HF. found...
A pesquisa analisa o impacto da evangelização sobre as práticas religiosas e os sistemas de crenças dos povos indígenas, evidenciando apagamento rituais mitologias ancestrais. O avanço das missões evangélicas promove uma reconfiguração identidades frequentemente associada à negação elementos culturais tradicionais. Esse fenômeno reflete um processo colonização simbólica, no qual a religiosidade cristã se impõe como única via legítima fé. Dito isso, estudo discute tensões entre tradição...
Cardiomyocytes have small potential for renovation and proliferation in vivo. Consequently, the heart muscle has limited capacity of self-renewal. Mesenchymal stem cells (MSC) therapy, as well MSC differentiated into cardiomyocytes, been used attempt to minimize effects ischemic-hypoxic lesions those affecting electrical conduction system heart.The present study compared three distinct protocols induced differentiation cardiomyocytes aimed at finding a viable method producing large number...
Recent reports suggest that n-3 (omega-3) polyunsaturated fatty acids (PUFAs) may reduce atrial fibrillation (AF). Reduction of the effective refractory period (ERP) is believed to be an important early remodeling event favors development and perpetuation AF. We hypothesized PUFAs would attenuate electrophysiolgical in a canine model acute tachypacing.Adult dogs either sex received (n=6), n-6 or saline (n=6) infused over 1 h. After stable ERP was established, treatment initiated concurrently...
I(Kur) (Ultra-rapid delayed rectifier current) has microM sensitivity to 4-aminopyridine (4-AP) and is an important modulator of the plateau amplitude action potential duration in canine atria. Kv1.5 encodes present both atria ventricles canines humans. We hypothesized that a similar outward current with 4-AP ventricle.We used established voltage clamp protocols (50 100 microM) measure normal myocytes isolated from left ventricular mid-myocardium.Action recordings presence showed significant...
We tested the effects of swimming training and insulin therapy, either alone or in combination, on intracellular calcium ([Ca(2+)]i) homeostasis, oxidative stress, mitochondrial functions diabetic rat hearts. Male Wistar rats were separated into control, diabetic, plus groups. Type 1 diabetes mellitus was induced by streptozotocin (STZ). Insulin-treated groups received to 4 UI daily for 8 wk. Each group divided sedentary exercised rats. Trained submitted (90 min/day, 5 days/wk, wk)....
OBJECTIVE:To test whether swimming training benefits femoral neck strength in young diabetic rats under insulin therapy.METHODS: A total of 60 male Wistar (age: 40 days) were divided equally into the following six groups: control sedentary, exercise, sedentary plus and exercise insulin.Diabetes was induced with a unique intraperitoneal injection (60 mg/kg body weight) streptozotocin.Seven days after 12 hours fasting, animals blood glucose levels X300 mg/dL considered diabetic.Seven induction...
The mechanisms of production, and gross, microscopic electrocardiograhic findings surgically-induced complete heart block (CHB) in the adult rat are presented. This is an effective vivo model for establishing alternative methods to electronic pacemakers providing detailed information aimed at replacement, reduction refinement technique. Sternal thoracotomy was employed identify epicardial fat pad by aortic root, used as a landmark cauterization atrioventricular (AV) node. Stable CHB produced...
The knowledge regarding labial salivary glands is becoming progressively more important, as their application in autologous transplantion, to promote ocular surface lubrication, are an ever-increasing procedure veterinary medicine. In this study the gland was collected, a single piece, along with oral mucosa from 10 adult dog cadavers. sample removed left lower lip marked by second premolar tooth and extended until distal edge of molar. Morphological, morphometric histochemical evalutations...
The lack of cardiac β1-adrenergic receptors (β1-AR) negatively affects the regulation both inotropy and lusitropy, leading, in long term, to heart failure (HF). Moderate-intensity aerobic exercise (MCAE) is recommended as an adjunctive therapy for patients with HF.We tested effects MCAE on contractile properties left ventricular (LV) myocytes from β1 adrenergic receptor knockout (β1ARKO) mice.Four- five-month-old male wild type (WT) β1ARKO mice were divided into groups: WT control (WTc)...
Traumatic spinal cord injury results in severe neurological deficits, mostly irreversible. The cell therapy represents a strategy for treatment particularly with the use of stem cells satisfactory several experimental models. aim study was to compare (SCI) and without mesenchymal (MSC), investigate whether MSCs migrate and/or remain at site injury, analyze effects on inflammation, astrocytic reactivity activation endogenous cells. Three hours after SCI, animals received bone marrow-derived...
Conflicting data are available concerning left ventricular (LV) function in patients after total correction of tetralogy Fallot (TOF). The response to afterload stress determined by methoxamine challenge and the peak systolic blood pressure-end-systolic volume relationship were evaluated echocardiographically 20 postoperative TOF (age range 9 15 years, mean 12 +/- 2). All without significant residual shunts or pulmonary stenosis. Results compared with those 10 control subjects 11 group had...
RESUMO Introdução: Biomarcadores vem sendo utilizados para monitorar o uso do álcool e, atualmente, os mais sensíveis e específicos são enzimas hepáticas, por exemplo, gama glutamiltransferase (GGT), alanina aminotransferase (ALT), aspartato (AST) fosfatase alcalina (ALP). Objetivo: Verificar, a partir da experimentação animal, as alterações provocadas pelo de pela prática atividade física nas hepáticas pancreáticas. Métodos: Vinte quatro ratos linhagem Wistar foram distribuídos...
Background: The effects of swimming training associated with insulin treatment on the cortical bone health in young rats severe type 1 diabetes remain unclear, although there is evidence such cancellous bone. This study examined combined therapy femoral midshaft structural and mechanical properties growing diabetes. Methods: Male Wistar were divided into six groups (n = 10): control sedentary, exercise, diabetic sedentary plus exercise insulin. Diabetic received an injection (60 mg/kg body...
The goal of this study was to confirm the vasopressor and cardiac effects POTENAY® INJETÁVEL (POT), a mephentermine-based product, given cattle with induced vascular/cardiac depression. Ten healthy Holstein (206 ± 13 kg) followed randomized-complete-block design (RCBD) utilizing crossover design. Each animal randomly received (1 ml/25 kg, IM) either POT (n = 10) or volume-matched placebo control (0.9%NaCl, CP, n 10). A subset animals 5) first (day 0) while remaining CP; after six-day washout...
O etanol afeta todas as células do organismo. Devido aos danos fisiológicos causados pelo seu consumo exagerado, novos modelos de tratamento coadjuvantes têm sido utilizados, dentre eles, a prática da atividade física (AF) aeróbica. Verificamos alterações provocadas uso álcool e pela AF no perfil lipídico ratos Wistar. Foram utilizados 24 animais machos, com 90 dias, divididos em quatro grupos experimentais (n=6): controle (sem álcool) sedentário (CS); exercitado (CE); alcoólico (AE); (AS)....