A5019167439- Inhalation and Respiratory Drug Delivery
- Bacterial biofilms and quorum sensing
- Antimicrobial Peptides and Activities
- Enzyme Catalysis and Immobilization
- Arts and Performance Studies
- Advanced Chemical Sensor Technologies
- Gene Regulatory Network Analysis
- Liver Disease Diagnosis and Treatment
- Microbial Metabolic Engineering and Bioproduction
- Biofuel production and bioconversion
- bioluminescence and chemiluminescence research
- Muscle metabolism and nutrition
- Cleft Lip and Palate Research
- Qualitative research in health
- Palliative and Oncologic Care
- Youth, Politics, and Society
- Biotechnology and Related Fields
- Literature, Culture, and Criticism
- History, Culture, and Society
- Adipose Tissue and Metabolism
- Viral Infectious Diseases and Gene Expression in Insects
- Agricultural and Food Sciences
- Dietary Effects on Health
- Infant Development and Preterm Care
University of Nottingham
2018-2022
Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Sul
2020
Universidade da Amazônia
2017
Universidade Federal de Viçosa
2015-2016
Abstract Inducible gene expression systems are vital tools for the advancement of synthetic biology. Their application as genetically encoded biosensors has potential to contribute diagnostics and revolutionise field microbial cell factory development. Currently, number compounds biological interest by far exceeds available biosensors. Here, we address this limitation developing a generic genome-wide approach identify transcription factor-based inducible systems. We construct validate 15...
Pseudomonas aeruginosa causes infections in patients with compromised epithelial barrier function. Multiple virulence factors produced by P. are controlled quorum sensing (QS) via 2-alkyl-4(1H)-quinolone (AQ) signal molecules. Here, we investigated the impact of AQs on PAO1 infection differentiated human bronchial cells (HBECs). The pqsA-E operon is responsible for biosynthesis including 2-alkyl-3-hydroxy-4-quinolones, 4-hydroxy-2-alkylquinolines, and 4-hydroxy-2-alkylquinoline N-oxides as...
Robust systematic approaches for the metabolic engineering of cell factories remain elusive. The available models predicting phenotypical responses and mechanisms are incomplete, particularly within context compound toxicity that can be a significant impediment to achieving high yields target product. This study describes Multi-Omic Based Production Strain Improvement (MOBpsi) strategy is distinguished by integrated time-resolved systems analyses fed-batch fermentations. As case study,...
RESUMO Introdução: Biomarcadores vem sendo utilizados para monitorar o uso do álcool e, atualmente, os mais sensíveis e específicos são enzimas hepáticas, por exemplo, gama glutamiltransferase (GGT), alanina aminotransferase (ALT), aspartato (AST) fosfatase alcalina (ALP). Objetivo: Verificar, a partir da experimentação animal, as alterações provocadas pelo de pela prática atividade física nas hepáticas pancreáticas. Métodos: Vinte quatro ratos linhagem Wistar foram distribuídos...
O etanol afeta todas as células do organismo. Devido aos danos fisiológicos causados pelo seu consumo exagerado, novos modelos de tratamento coadjuvantes têm sido utilizados, dentre eles, a prática da atividade física (AF) aeróbica. Verificamos alterações provocadas uso álcool e pela AF no perfil lipídico ratos Wistar. Foram utilizados 24 animais machos, com 90 dias, divididos em quatro grupos experimentais (n=6): controle (sem álcool) sedentário (CS); exercitado (CE); alcoólico (AE); (AS)....
An investigation of Pseudomonas aeruginosa attachment to a diverse range polymers in high-throughput microarray format resulted the discovery novel biofilm-resistant and biofilm-stimulating materials. These findings raised questions about nature surface interactions involved particular sensory mechanisms use by P. distinguish between different chemistries. To further investigate this, Tn5 mutants PAO1 Washington sub-line were tested for biofilm formation on polymer microarrays. This revealed...
A encefalocele é considerada como um defeito do tubo neural e caracteriza-se pela protrusão tecido encefálico através de uma falha estrutural ósseo craniano. Este estudo teve objetivo implementar estratégias em busca da otimização cuidado paliativo ao paciente pediátrico portador encefalocele. Tratou-se descritivo, tipo relato caso, dos cuidados enfermagem a má formação congênita, hospital referência atendimento neonatal. Devido í gravidade equipe foi orientada manter paliativos, para...