A5048683231- Vascular Procedures and Complications
- Peripheral Artery Disease Management
- Anesthesia and Neurotoxicity Research
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Cardiac Ischemia and Reperfusion
- Acute Ischemic Stroke Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Health and Disease Prevention
- Exercise and Physiological Responses
- Cardiac Arrest and Resuscitation
- Venous Thromboembolism Diagnosis and Management
- Heart Rate Variability and Autonomic Control
- Transplantation: Methods and Outcomes
- Nitric Oxide and Endothelin Effects
- Aortic aneurysm repair treatments
- Redox biology and oxidative stress
- Menopause: Health Impacts and Treatments
- Mitochondrial Function and Pathology
- Cardiovascular Effects of Exercise
- Sex and Gender in Healthcare
- Cardiovascular and exercise physiology
- Estrogen and related hormone effects
University of Alabama at Birmingham
2020
East Carolina University
2013-2014
We recently showed that Bendavia, a novel mitochondria-targeting peptide, reduced infarction and no-reflow across several experimental models. The purpose of this study was to determine the therapeutic timing mechanism action underlie Bendavia’s cytoprotective property. In rabbits exposed in vivo ischemia/reperfusion (30/180 min), Bendavia administered 20 minutes prior reperfusion (0.05 mg/kg/h, intravenously) myocardial infarct size by ∼50% when for either 1 or 3 hours reperfusion. However,...
We have previously shown that exercise leads to sustainable cardioprotection through a mechanism involving improved glutathione replenishment. This study was conducted determine if redox-dependent modifications in reductase (GR) were involved cardioprotection. Furthermore, we sought reactive oxygen species generated by NADPH oxidase and/or mitochondria during triggering events for GR modulations.Rats exercised 10 consecutive days, after which isolated hearts exposed ischaemia/reperfusion (25...
Background Vein conduit is known to have better patency than prosthetic for infrainguinal bypass. Here we explore if racial disparities exist in bypass vein use amid preoperative patient and systemic factors. Methods Retrospective Society Vascular Surgery Quality Initiative data 23,959 bypasses between 2003 2017 occlusive disease were analyzed. For homogeneity, only originating from the common femoral artery included. Demographics of patients receiving vs compared logistic regression...
Bendavia is a mitochondria‐targeted peptide that protects the heart against ischemia‐reperfusion (I/R) injury in wide range of experimental models. We have previously shown Bendavia's mechanism action involves lowering intracellular levels reactive oxygen species (ROS). As other compounds lower ROS can abrogate protective effects ischemic preconditioning (IPC), this study was conducted to determine if influenced protection evoked by IPC. Isolated guinea pig hearts were put into one 4 groups:...