A5081139078- Cardiovascular Conditions and Treatments
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Congenital heart defects research
- Cardiac Arrhythmias and Treatments
- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Cardiac Valve Diseases and Treatments
- Sports injuries and prevention
- Human-Animal Interaction Studies
- Muscle Physiology and Disorders
- Renin-Angiotensin System Studies
- Cardiac Arrest and Resuscitation
- Pulmonary Hypertension Research and Treatments
- Veterinary Medicine and Surgery
- Pharmacological Effects and Assays
- Wnt/β-catenin signaling in development and cancer
- Veterinary Equine Medical Research
- Cardiovascular Syncope and Autonomic Disorders
- Receptor Mechanisms and Signaling
- Veterinary Pharmacology and Anesthesia
- Vector-Borne Animal Diseases
- Neuroscience of respiration and sleep
- Tissue Engineering and Regenerative Medicine
North Carolina State University
2016-2025
North Central State College
2021
University of Minnesota
2019
University of Prince Edward Island
2018
North Carolina Clinical Research
2017
Washington State University
2006-2015
Swedish University of Agricultural Sciences
2015
University of California, Davis
2007-2015
Tufts University
2001-2015
Chesapeake Urology Associates
2015
Background— Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a primary familial heart muscle disease associated with substantial cardiovascular morbidity and risk of sudden death. Efforts to discern relevant pathophysiological mechanisms have been impaired by lack suitable animal model. Methods Results— ARVC was diagnosed in 23 boxer dogs (12 male; 9.1±2.3 years old). Clinical events alone or combination included death (n=9; 39%), arrhythmias suspected (RV) origin (n=19; 83%),...
Background —A naturally occurring animal model of familial hypertrophic cardiomyopathy (FHCM) is lacking. We identified a family Maine coon cats with HCM and developed colony to determine mode inheritance, phenotypic expression, natural history the disease. Methods Results proband was identified, related were bred produce colony. Affected unaffected inheritance. Echocardiography used identify affected offspring expression. Echocardiograms repeated serially Of 22 from breeding cats, 12 (55%)...
Hypertrophic cardiomyopathy (HCM) is one of the most common causes sudden cardiac death in young adults and a familial disease at least 60% cases. Causative mutations have been identified several sarcomeric genes, including myosin binding protein C (MYBPC3) gene. Although numerous causative identified, pathogenetic process still poorly understood. A large animal model HCM cat has may be used for additional study. As first spontaneous this disease, feline provides valuable investigators to...
Abstract Objective —To determine the efficacy of long-term enalapril administration in delaying onset congestive heart failure (CHF). Design —Placebo-controlled, double-blind, multicenter, randomized trial. Animals —124 dogs with compensated mitral valve regurgitation (MR). Procedures —Dogs randomly assigned to receive or placebo were monitored for primary endpoint CHF ≤ 58 months. Secondary endpoints included time from study entry combined CHF-all-cause death; number free at 500, 1,000, and...
To evaluate the breed distribution of ABCB1-1Delta polymorphism in a large number dogs North America, including several herding breeds which this has been detected and other not yet identified.Cross-sectional study.5,368 from buccal swab samples were collected for purposes ABCB1 genotyping.From May 1, 2004, to September 30, 2007, DNA specimens derived 5,368 underwent genotyping. These data reviewed, results each dog recorded spreadsheet, along with dog's breed. The genotypes tallied by use...
Background Myocardial disease in the Boxer dog is characterized by 1 of 2 clinical presentations, dilated cardiomyopathy (DCM) ventricular systolic dysfunction, dilatation and tachyarrhythmias, arrhythmogenic right ( ARVC ) syncope, sudden death. has been associated with a deletion striatin gene some families. Hypothesis/Objectives We hypothesized that both presentations represent single disease, development DCM deletion. Animals Thirty‐three adult dogs , 29 16 Boxers without cardiac...
Abstract The development of high throughput SNP genotyping technologies has improved the genetic dissection simple and complex traits in many species including cats. properties feline 62,897 SNPs Illumina Infinium iSelect DNA array are described using a dataset over 2,000 samples, most extensive to date, representing 41 cat breeds, random bred population, four wild felid species. Accuracy efficiency array’s genotypes its utility performing population-based analyses were evaluated. Average...
ABSTRACT Background Familial narcolepsy in dogs has been associated with mutations the HCRTR2 gene Labrador retrievers, dachshunds, and Doberman pinschers, causal mutation differing between breeds. Objective To characterize genetic responsible for familial Dogo Argentino dogs. Animals Ten dogs, three narcoleptic seven clinically normal, of which four were related unrelated to Methods Case control prospective study. DNA was extracted from blood samples all Whole‐genome sequencing performed on...
Abstract Objective —To evaluate the use of 24-hour ambulatory electrocardiography (AECG) for detection ventricular premature complexes (VPC) in healthy dogs. Design —Case series. Animals —50 mature Procedure —A AECG was performed on each dog and evaluated presence VPC. Results —Fifty dogs weighing between 18.2 to 40.9 kg (40 90 lb) representing 13 breeds were evaluated; there 4 sexually intact females, 21 spayed males, castrated males. Ages ranged from 1 12 years. Thirty-four had no VPC; 16...
Abstract Objective —To evaluate the effect of 4 antiarrhythmic treatment protocols on number ventricular premature complexes (VPC), severity arrhythmia, heart rate (HR), and syncopal episodes in Boxers with tachyarrhythmias. Design —Randomized controlled clinical trial. Animals —49 Boxers. Procedure —Dogs > 500 VPC/24 h via 24-hour ambulatory ECG (AECG) were treated atenolol (n = 11), procainamide (11), sotalol (16), or mexiletine (11) for 21 to 28 days. Results pre- posttreatment AECG...
The purposes of this study were to evaluate families Boxers with ventricular arrhythmias determine whether disorder is a familial trait and, if so, the mode inheritance. Eighty-two evaluated by physical examination, electrocardiogram, echocardiogram, and 24-hour ambulatory electrocardiogram. Dogs considered affected at least 50 premature complexes (PVCs) observed during period. All dogs 6 years age evaluation. Complete cardiovascular examinations performed on from extended families. 2 most...
Abstract Objective —To evaluate serum cardiac troponin I (cTnI) concentrations in Boxers with arrhythmogenic right ventricular cardiomyopathy (ARVC), unaffected (control) Boxers, and control non-Boxers. Animals —10 a clinical diagnosis of ARVC defined by ≥ 1,000 premature complexes (VPCs)/24 h on an ambulatory ECG, 10 assessed as normal the presence < 5 VPCs/24h, Procedures —Serum was extracted from blood sample each dog. Analysis cTnI performed. Results —Mean ± SD concentration 0.142...
Background Boxer arrhythmogenic right ventricular cardiomyopathy ( ARVC ) is a disease that may result in sudden death or heart failure. Hypothesis/objectives To prospectively study the natural history of . Animals 72 dogs (49 , 23 controls). Methods Boxers >1 year age were recruited for annual reevaluation. Controls defined as being ≥6 years and having <50 premature complex VPC s)/24 h. was ≥300 s/24 h absence other disease. Dogs genotyped striatin deletion when possible. Descriptive...
To assess survival time and adverse events related to the administration of pimobendan cats with congestive heart failure (CHF) secondary hypertrophic cardiomyopathy (HCM) or obstructive (HOCM).Retrospective case-control study.27 receiving treatment 27 without pimobendan.Medical records between 2003 2013 were reviewed. All HCM HOCM treated a regimen that included (case cats) identified. Control (cats CHF during same period did not include pimobendan) selected by matching case on basis age,...
The purposes of this study were to evaluate families Boxers with ventricular arrhythmias determine whether disorder is a familial trait and, if so, the mode inheritance. Eighty‐two evaluated by physical examination, electrocardiogram, echocardiogram, and 24‐hour ambulatory electrocardiogram. Dogs considered affected at least 50 premature complexes (PVCs) observed during period. All dogs 6 years age evaluation. Complete cardiovascular examinations performed on from extended families. 2 most...