A5086450445- Cardiovascular Conditions and Treatments
- Congenital Heart Disease Studies
- Renin-Angiotensin System Studies
- Cardiomyopathy and Myosin Studies
- Heart Failure Treatment and Management
- Electrolyte and hormonal disorders
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Hemodynamic Monitoring and Therapy
- Cardiac Arrhythmias and Treatments
- Congenital heart defects research
- Cardiovascular Effects of Exercise
- Renal function and acid-base balance
- Acute Myocardial Infarction Research
- Veterinary Pharmacology and Anesthesia
- Mechanical Circulatory Support Devices
- Veterinary Oncology Research
- Hormonal Regulation and Hypertension
- Human-Animal Interaction Studies
- Neuroscience of respiration and sleep
- Infective Endocarditis Diagnosis and Management
- Cardiac electrophysiology and arrhythmias
- Vascular anomalies and interventions
- Venous Thromboembolism Diagnosis and Management
- Veterinary Equine Medical Research
University of Florida
2006-2025
Florida College
2005-2023
North Carolina State University
2016-2021
North Carolina Clinical Research
2017
Carolina Veterinary Specialists
2007
Cornell University
2007
Raytheon Technologies (Finland)
2007
University of California, Davis
1999-2002
Veterinary Medical Teaching Hospital
1999-2001
Recent studies have investigated dogs with presumed diet-associated dilated cardiomyopathy (daDCM), but prospective of multiple breeds are needed.
Two wild adult bald eagles (Haliaeetus leucocephalus) were presented to the University of Florida zoological medicine department on separate dates, both being unable fly. One eagle had a fracture left humerus, and second no external injuries. Thoracic radiographs animals revealed cardiomegaly, echocardiography reduced systolic function. Both treated with oral pimobendan until recheck documented normal Several weeks after was discontinued, echocardiograms showed function considered normal....
The impact of exercise on the classical and alternative renin-angiotensin-aldosterone system (RAAS) pathways has not been studied in horses. We hypothesized that would activate both RAAS endurance cause more activation pathway compared to short-duration, high-intensity Twenty-five horses (21 client-owned 4 research) were included groups (10 Arabians, 50-mile ride [A-E]; thoroughbreds, 1-mile treadmill [TB-TM]; 5 1-1/16th-mile race [TB-R]; 6 quarter 330-500-yard [QH-R]). Blood was collected...
Objectives Dilated cardiomyopathy (DCM) is a common cause of acquired cardiac disorder in dogs, second only to myxomatous mitral valve disease (MMVD). This study aimed describe the thoracic radiographic features cardiogenic pulmonary oedema dogs with DCM. Materials and Methods Thoracic radiographs left‐sided congestive heart failure an echocardiographically confirmed diagnosis DCM were included this retrospective study. Radiographs retrospectively reviewed by two radiologists assess...
Antidiuretic hormone (ADH) is upregulated in dogs with cardiac disease. However, measurement of ADH impractical a clinical setting. Copeptin co-secreted ADH, making it potential biomarker secretion. We hypothesized that disease would upregulate copeptin concentrations and positively correlate serum chloride ([Cl−]), degree mathematical [Cl−] correction. The study population comprised 19 healthy, 20 preclinical (Stage B), congestive heart failure (CHF, Stage C or D) dogs. Groups were compared...
Cardiac troponin I (cTnI), a myocardial polypeptide, is highly sensitive and specific biomarker of injury in people dogs. The structure cTnI conserved across species, equine myocardium has high reactivity with human immunoassays. purpose this study was to describe concentrations normal pastured race-training Thoroughbred horses. Ten horses on pasture 10 race training were studied. Horses considered the basis physical examination, performance, electrocardiography (ECG), echocardiography....
Background: Owners' perceptions and priorities regarding quality of life (QoL) are important considerations given the unknown efficacy many commonly administered medications, stress hospital visits, difficulties providing home care, personal choices including euthanasia. Objective: To describe relative importance versus quantity to owners cats with heart disease. Animals: Two hundred thirty-nine Methods: Prospective questionnaire-based clinical study. Cat completed a questionnaire identify...
Background Cardiac biomarkers provide objective data that augments clinical assessment of heart disease ( HD ). Hypothesis/Objectives Determine the utility plasma N‐terminal pro‐brain natriuretic peptide concentration [NT‐proBNP] measured by a 2nd generation canine ELISA assay to discriminate cardiac from noncardiac respiratory distress and evaluate severity. Animals Client‐owned dogs (n = 291). Methods Multicenter, cross‐sectional, prospective investigation. Medical history, physical...
This paper details the development of a novel wireless heart rate sensing system for puppies in training as guide dogs. The includes harness with on-board electrocardiography (ECG) front-end circuit, inertial measurement unit and micro-computer capability where major research focus this was on ergonomic design evaluation puppies. first phase our performed Labrador Retriever between 12 to 26 weeks age pilot study. longitudinal weekly data collected revealed expected trend decreasing average...
Abstract Background Associations of diet with dilated cardiomyopathy are under investigation. Objectives That cardiac assessment would show abnormalities in healthy dogs eating grain‐free (GF) diets or Food and Drug Administration (FDA)‐listed ingredients concern (peas, lentils, potatoes) as top 10 (FDA‐PLP), but not grain‐inclusive (GI) without FDA‐listed (PLP) the (NoFDA‐PLP). Animals One hundred eighty‐eight Doberman Pinschers, Golden Retrievers, Miniature Schnauzers, Whippets. Methods...
Abstract Background Familial hypertrophic cardiomyopathy is a common inherited cardiovascular disorder in people. Many causal mutations have been identified, but about 40% of cases do not known causative mutation. Mutations the ALMS1 gene are associated with development Alstrom syndrome, multisystem familial disease that can include (dilated, restrictive). Hypertrophic has described. The large encodes for ubiquitously expressed protein. function protein well understood although it believed...
Several studies in human subjects have demonstrated greater diuresis with constant rate infusion (CRI) furosemide than intermittent bolus (IB) furosemide. This study was conducted to compare the diuretic efficacy of same total dose IB and CRI 6 healthy, adult Greyhound dogs a randomized crossover design 2‐week washout period between treatments. For administration, received 3 mg/kg at 0 4 hours. 0.66 loading followed by mg/kg/h over 8 The volume fluid administered for both methods. Urine...
Abstract Background Refractory congestive heart failure (CHF) and associated diuretic resistance are not well defined. Objectives To characterize renal function, electrolyte concentrations, indices of efficacy, renin‐angiotensin‐aldosterone system (RAAS) activation in dogs with naturally occurring disease (HD) American College Veterinary Internal Medicine stages B1, B2, C, D to determine their usefulness defining HD stages. Animals Group 1:149 D. 2:22 C Methods 1: Renal parameters, serum...
Abstract Background An angiotensin‐converting enzyme (ACE) gene polymorphism occurs in dogs; however, functional importance is not well studied. Hypothesis We hypothesized that dogs with the would show alternative renin‐angiotensin aldosterone system (RAAS) pathway activation and classical RAAS suppression before after ACE‐inhibitor administration, as compared to without this pattern only administration. Animals Twenty‐one mitral valve disease were genotyped for ACE polymorphism. Methods...
The objective of this study was to assess 2 noninvasive methods measuring cardiac output (CO) in neonatal foals by comparing results that the lithium-dilution method. Ten were anesthetized and CO manipulated varying depth anesthesia infusion dobutamine. Concurrent measurements obtained lithium dilution (reference method), partial carbon dioxide (CO2) rebreathing, volumetric echocardiography (cubic, Teichholz, Bullet, area-length, single biplane modified Simpson formulas), transthoracic...
Background:Recent interest in cardiac biomarkers has led to the validation of several commercial analyzers for troponin I (cTnI) evaluation dogs; however, these have not been standardized. Hypothesis:It was hypothesized that canine plasma cTnI concentrations as determined by 3 different would be similar. Animals:Twenty‐three dogs with disease were studied. Methods:Reconstituted purified free diluted 8 (0.01, 0.1, 0.78, 1.56, 3.13, 6.25, 12.5, and 25 ng/mL), analysis analyzers, Biosite Triage...
Background:Recent interest in cardiac biomarkers has led to the validation of several commercial analyzers for troponin I (cTnI) evaluation dogs; however, these have not been standardized. Hypothesis:It was hypothesized that canine plasma cTnI concentrations as determined by 3 different would be similar. Animals:Twenty-three dogs with disease were studied. Methods:Reconstituted purified free diluted 8 (0.01, 0.1, 0.78, 1.56, 3.13, 6.25, 12.5, and 25 ng/mL), analysis analyzers, Biosite Triage...
Man-made technological odor detection systems continue to improve but still cannot match the tracking efficiency, mobility, and selectivity in presence of interfering odors achieved by detector dogs. The reliability dogs as olfactory detectors does not depend solely on their performance also handler's skill interpreting behavior dog that signals target odor. We present our efforts a wireless wearable system combining electrocardiogram (ECG) an electronic stethoscope for direct monitoring...
To evaluate the frequency of variants in pyruvate kinase dehydrogenase 4 (PDK4) and titin (TTN) genes a group Doberman Pinschers with dilated cardiomyopathy (DCM) to determine whether there were unique clinical attributes each variant.48 DCM.Doberman recently diagnosed DCM identified, genomic DNA from was genotyped PCR assay for detection PDK4 TTN genetic variants. Dogs grouped on basis they had variant alone, both variants, or neither variant. Descriptive statistics compiled dog age, body...