A5031489598- Cardiomyopathy and Myosin Studies
- Virus-based gene therapy research
- Respiratory viral infections research
- Congenital heart defects research
- RNA modifications and cancer
- Bone Tumor Diagnosis and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Air Quality and Health Impacts
- Cardiovascular Effects of Exercise
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Neurotoxicity Research
- RNA and protein synthesis mechanisms
- Cardiac Arrhythmias and Treatments
- dental development and anomalies
- Carcinogens and Genotoxicity Assessment
- Cardiovascular Conditions and Treatments
- Neurogenetic and Muscular Disorders Research
- Veterinary Orthopedics and Neurology
- Free Radicals and Antioxidants
- Cellular transport and secretion
- Hearing, Cochlea, Tinnitus, Genetics
- Muscle Physiology and Disorders
- Bacteriophages and microbial interactions
National Institute of Environmental Health Sciences
2014-2023
North Carolina State University
2018-2020
University of North Carolina Wilmington
2020
Background We aimed to identify mutations associated with osteochondromatosis in a litter of American Staffordshire Terrier puppies. Hypothesis hypothesized that the mutation would be located gene causes humans. Animals A 9 puppies, their sire and dam, 3 4 grandparents, 26 healthy unrelated Terriers, 154 dogs 27 different breeds. Methods Whole genome sequencing was performed on proband, variants were compared against polymorphisms derived from additional across breeds, as well single...
Abstract Toll‐like receptor 4 (TLR4) is primarily responsible for initiating an immune response following pathogen recognition. However, TLR4 also expressed on neural progenitor cells and has been reported to regulate hippocampal neurogenesis as young male knockout mice show increases in cell proliferation doublecortin positive cells. Whether these effects occur both sexes are sustained with normal aging currently unknown. The present study evaluated whether deficiency alters adult (3–4...
Background A congenital syndrome of hearing loss and vestibular dysfunction affects Doberman Pinschers. Its inheritance pattern is suspected to be autosomal recessive it potentially represents a spontaneous animal model an syndromic loss. Hypothesis/Objectives The objectives this study were use whole genome sequencing (WGS) identify deleterious genetic variants in candidate genes associated with the prevalence among population unaffected Animals One affected Pinscher 202 Methods WGS dog...
Identifying and understanding genetic factors that influence the propagation of human respiratory syncytial virus (RSV) can lead to health benefits possibly augment recent vaccine approaches. We previously identified a p53/immune axis in which tumor suppressor p53 directly regulates expression immune system genes, including seven members APOBEC3 family DNA cytidine deaminases (A3), are innate sentinels against viral infections. Here, we examined potential A3 RSV infection, as well overall...
Background Respiratory syncytial virus (RSV) infects nearly all children by theirsecond year of life with re‐infections occurring throughout adolescence andadulthood. RSV infection typicallyresults in mild host symptoms. However, susceptible individuals can develop severe lower respiratory tract infectionsand bronchiolitis, sometimes leading to hospitalization or death. Recently we established that addition toits protective role against cancer development, the tumor suppressor p53...