A5040643126- Chromatin Remodeling and Cancer
- MicroRNA in disease regulation
- Mechanisms of cancer metastasis
- Circular RNAs in diseases
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related gene regulation
- RNA regulation and disease
- Wnt/β-catenin signaling in development and cancer
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- Caveolin-1 and cellular processes
- Glioma Diagnosis and Treatment
- RNA Research and Splicing
- Kruppel-like factors research
- Histone Deacetylase Inhibitors Research
- Cancer, Hypoxia, and Metabolism
- DNA Repair Mechanisms
- Spectroscopy Techniques in Biomedical and Chemical Research
- Erythrocyte Function and Pathophysiology
- Microtubule and mitosis dynamics
- Cancer-related Molecular Pathways
- Protein Degradation and Inhibitors
Henan Provincial People's Hospital
2025
Zhengzhou University
2025
City Of Hope National Medical Center
2021-2025
Second Affiliated Hospital of Harbin Medical University
2025
Harbin Medical University
2025
Zhejiang A & F University
2024
Beijing Radiation Center
2024
City of Hope
2024
Beijing University of Chemical Technology
2023
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2017-2022
Significance Cancer stem cells (CSCs) exhibit enhanced chemo/radiotherapy resistance, and their survival following cancer treatment is believed to be responsible for tumor recurrence metastasis. Thus, understanding the mechanisms through which CSCs survive conventional chemotherapy essential identification of new therapeutic strategies prevent relapse. Our findings that ovarian cisplatin elevated expression polymerase η represent an opportunity eradicate improve patients. In addition, miR-93...
Desmosomes are intercellular junctions that confer strong cell-cell adhesion, thus conferring resistance against mechanical stress on epithelial tissues. A body of evidence indicates decreased expression desmosomal proteins is associated with poor prognosis in various cancers. As a key component plaque proteins, the functional role desmoplakin (DSP) cancer not yet elucidated. Here, we reported anti-tumorigenic activity DSP non-small cell lung (NSCLC). We found by DNA methylation was...
Cancer stem cells (CSC) play a central role in cancer metastasis and development of drug resistance. miRNA are important regulating CSC properties considered potential therapeutic targets. Here we report that miR-328-3p (miR-328) is significantly upregulated ovarian CSC. High expression miR-328 maintained by directly targeting DNA damage binding protein 2, which has been shown previously to inhibit Reduced activity ERK signaling CSC, mainly due low level reactive oxygen species, contributed...
The level of microRNA-93 (miR-93) in tumors has been recently reported to be negatively correlated with survival lung cancer patients. Considering that the most devastating aspect is metastasis, which can promoted by transforming growth factor-β (TGF-β)-induced epithelial-to-mesenchymal transition (EMT), we sought determine whether miR-93 involved this process. Here, report a previously unidentified target miR-93, neural precursor cell expressed developmentally downregulated gene 4-like...
Lactobacillus plantarum (L. plantarum) has been globally regarded as antibiotic alternative in animal farming the past few years. However, potential function of L. broilers not systemically explored. In this study, a total 560 one-day-old yellow-feathered were randomly divided into 3 groups, fed with basal diet and drank HJZW08 (LP) at concentration 0 (CON), 1000 × 10^5 (LP1000), 2000 CFU/L (LP2000) for 70 d. Results showed that body weight (BW), average daily gain (ADG), feed intake (ADFI),...
Desmocollin 3 (DSC3), a member of the cadherin superfamily and integral component desmosomes, is involved in carcinogenesis. However, role DSC3 colorectal cancer (CRC) has not yet been established. expression CRC cell lines was analysed by RT–PCR western blotting. Methylation status examined demethylation tests, methylation-specific PCR, bisulphite sequencing (BS). The regulatory p53 investigated transfection. downregulated cells at mRNA protein levels. restored five out seven after...
Blood–brain barrier (BBB) dysfunction has been suggested to play an important role in epilepsy. However, the mechanism mediating transition from cerebrovascular damage epilepsy remains unknown. Here, we report that endothelial cyclin-dependent kinase 5 (CDK5) is a central regulator of neuronal excitability. Endothelial-specific Cdk5 knockout led spontaneous seizures mice. Knockout mice showed increased chemokine (C-X-C motif) ligand 1 (Cxcl1) expression, decreased astrocytic glutamate...
Desmosomes are intercellular junctions that confer strong cell–cell adhesion. Altered expression of desmocollin 3 (DSC3), a member the desmosomal cadherin family, was found in various cancers; however, its functional involvement carcinogenesis has not yet been elucidated. Expression/localization DSC3 analyzed by real-time reverse transcription–PCR, western blotting, immunofluorescence and immunohistochemistry. Methylation status examined demethylation tests, methylation-specific PCR...
Discretely orchestrated chromatin condensation is important for chromosome protection from DNA damage. However, it still unclear how different states affect the formation and repair of nucleotide excision (NER) substrates, e.g. ultraviolet (UV)-induced cyclobutane pyrimidine dimers (CPD) (6-4) pyrimidone photoproducts (6-4PP), as well cisplatin-induced intrastrand crosslinks (Pt-GG). Here, by using immunofluorescence immunoprecipitation assays, we have demonstrated that CPD, which cause...
The expression of DNA damage-binding protein 2 (DDB2) has been linked to the prognosis ovarian cancer and its underlying transcription regulatory function was proposed contribute favorable treatment outcome. By applying gene microarray analysis, we discovered neural precursor cell expressed, developmentally downregulated 4-Like (NEDD4L) as a previously unidentified downstream regulated by DDB2. Mechanistic investigation demonstrated that DDB2 can bind promoter region NEDD4L recruit enhancer...
Abstract HOPX acts as a tumour suppressor in various cancers. However, the regulation of human lung cancer well mechanism underlying its tumour‐suppressive function has not yet been elucidated. Here we investigated epigenetic and molecular by which exerts growth inhibitory effects. We found that was down‐regulated 12 out 13 cell lines 69 120 primary tumours at mRNA protein levels. Patients with adenocarcinoma ( ADC ) exhibited significantly more positive staining compared squamous carcinoma...
<i>Objectives:</i> The expression patterns of cytokeratin (CK) filaments in human epithelial neoplasms are complex and distinctive. aims this study were to analyze CK evaluate the diagnostic application CKs non-small cell lung cancer (NSCLC). <i>Methods:</i> mRNA CK5, CK6, CK14, CK15, CK17, CK19 was analyzed by Northern blotting. Protein CK5/6, CK7, CK18 evaluated immunohistochemistry on tissue microarrays. <i>Results:</i> blotting showed that highly...
Objective Desmosomes are intercellular junctions that confer strong cell–cell adhesion. Two main members of desmosomal cadherins, desmogleins (DSGs) and desmocollins (DSCs), involved in carcinogenesis. However, their role human lung cancer remained elusive. The aims this study were to analyse the expression DSCs evaluate clinical application cancer. Methods DSC1-3 mRNAs was analysed by RT-PCR. methylation status demethylation tests bisulphite sequencing. Protein primary evaluated...
// Tiantian Cui 1 , Amit Kumar Srivastava Chunhua Han Linlin Yang 2 Ran Zhao Ning Zou Meihua Qu Wenrui Duan 3 Xiaoli Zhang 4 and Qi-En Wang Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, USA Radiation Oncology, Internal Medicine, Center for Biostatistics, Correspondence to: Wang, email: Keywords : XPC, E-Cadherin, non-small-cell lung cancer, Snail, ERK pathway Received December 28, 2014 Accepted February 13, 2015 Published March 12, Abstract Xeroderma...
Piperine (PPR) is the representative alkaloid component of piper species (family: Piperaceae). Our rapid screening study found PPR caused time-dependent inhibition cytochrome P450s (CYP) 3A and 2D6, CYP3A was inactivated most. Further demonstrated that a time-, concentration-, NADPH-dependent inhibitor CYP3A, significant loss (49.5% ± 3.9%) activity observed after 20minute incubations with 80 <i>μ</i>M at 37°C. The values <i>K</i><sub>I</sub> <i>k</i><sub>inact</sub> were 30.7 0.041...
Hypoxia contributes to a cascade of inflammatory response mechanisms in kidneys that result the development renal interstitial fibrosis and subsequent chronic failure. Nonetheless, kidney possesses self-protection mechanism under certain degree hypoxia this its adaptation hypoxia. As hypoxia-inducible factor (HIF)-vascular endothelial growth (VEGF) axis is key pathway for neovascularization, activation target therapies.Sprague-Dawley rats were exposed normobaric subdivided into three groups,...
Pancreatic ductal adenocarcinoma (PDAC) is characterized by its nutrient-scavenging ability, crucial for tumor progression. Here, we investigated the roles of caveolae-mediated endocytosis (CME) in PDAC Analysis patient data across diverse datasets revealed a strong association high caveolin-1 (Cav-1) expression with higher histologic grade, most aggressive molecular subtypes, and worse clinical outcomes. Cav-1 loss markedly promoted longer overall tumor-free survival genetically engineered...
Abstract Purpose: Pancreatic cancer (PC) is an aggressive lethal tumor with unmet need for novel therapeutic approaches. KRAS activating mutations occur in 90-95% of PC and contribute to progression resistance therapy, including radiation. The mechanisms by which oncogenic promotes radiation are critical understand order identify therapies. Methods: We first analyzed the expression levels DNA damage response repair genes using Affymetrix RNA microarray isogenic HCT116 SW48 cells wide-type...
Background Papillary thyroid carcinoma coexisting with rheumatoid arthritis is frequently observed in clinical patients, yet its pathogenesis has not been fully elucidated. This investigation sought to further explore the molecular underpinnings of these two diseases. Methods Gene expression profiles for papillary and patients were obtained from Comprehensive Expression Database (GEO). Following discovery shared differentially expressed genes (DEGs) between conditions, three separate...