A5021178369- Caveolin-1 and cellular processes
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Metabolism, Diabetes, and Cancer
- DNA Repair Mechanisms
- Pancreatic and Hepatic Oncology Research
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2024
The Ohio State University Wexner Medical Center
2024
The Ohio State University
2019
Pancreatic ductal adenocarcinoma (PDAC) is characterized by its nutrient-scavenging ability, crucial for tumor progression. Here, we investigated the roles of caveolae-mediated endocytosis (CME) in PDAC Analysis patient data across diverse datasets revealed a strong association high caveolin-1 (Cav-1) expression with higher histologic grade, most aggressive molecular subtypes, and worse clinical outcomes. Cav-1 loss markedly promoted longer overall tumor-free survival genetically engineered...
Abstract mTOR signaling pathway is deregulated in most cancers and uncontrolled cell cycle progression a hallmark of cancer cell. However, the precise molecular mechanisms regulation DNA replication chromatin metabolism by are largely unknown. We herein report that promotes loading MCM2-7 helicase onto upregulates licensing factor CDC6. Pharmacological inhibition kinase resulted CHK1 checkpoint activation decreased PCNA associated with chromatins. Further pharmacological genetic studies...