A5007821103- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Research Studies
- Genetic factors in colorectal cancer
- Histiocytic Disorders and Treatments
- Gastrointestinal disorders and treatments
- Testicular diseases and treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Medical Imaging and Pathology Studies
- Congenital Anomalies and Fetal Surgery
- Sarcoma Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Vascular Malformations and Hemangiomas
- Gallbladder and Bile Duct Disorders
- Lymphoma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Lung Cancer Treatments and Mutations
- Oral and Maxillofacial Pathology
- Renal cell carcinoma treatment
- Metastasis and carcinoma case studies
- Cancer Genomics and Diagnostics
- Viral-associated cancers and disorders
Indiana University School of Medicine
2016-2025
Indiana University – Purdue University Indianapolis
2017-2025
Indiana University Indianapolis
2022
Indiana University Health
2022
University of Indianapolis
2021
Ascension Providence Hospital
2021
Indiana University
2016-2021
Shifa International Hospital
2017
Rush University Medical Center
2017
Columbia College - Missouri
2017
The RAS family is among the most commonly mutated genes in all human malignancies including colon cancer. In normal cells, proteins act as a link intracellular signal transduction initiated by binding of growth factors to cell membrane receptors mediating survival. isoproteins have great morphological similarities, but despite that, they are thought different functions tissues. mutations, supported several studies animal models, role development and progression colorectal detection mutations...
Background:Mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE) is an autosomal recessive disease caused by thymidine phosphorylase deficiency leading to progressive gastrointestinal dysmotility, cachexia, ptosis, ophthalmoparesis, peripheral neuropathy and leukoencephalopathy.Although liver transplantation corrects deficiency, intestinal of the enzyme persists.Retrospective chart review was carried out obtain clinical, biochemical, pathological details. Case Report:We present...
STAT6 stain has proved to be a good surrogate marker for the genetic alteration (NAB2-STAT6 gene fusion) in solitary fibrous tumor (SFT). This study aims validate use of rabbit monoclonal antibody differentiating SFT from its histologic mimics. Forty-five cases and 110 9 other spindle cell tumors were collected immunostaining. Positive nuclear staining was present all 45 (100% sensitivity). No identified neoplasms (0/13, dedifferentiated liposarcoma; 0/17, synovial sarcoma; 0/16, malignant...
Testicular seminomas require accurate staging for effective management. Twenty per cent are metastatic at presentation, while 80% clinical stage I, requiring only orchiectomy and surveillance. Tumour size, rete testis invasion, hilar soft tissue invasion lymphovascular have been shown to incur a higher risk of metastasis recurrence in I seminomas, with little congruence between studies.We reviewed 211 cases testicular recorded patient age, tumour testis, tissue, epididymis, spermatic cord,...
TFE3 -fusion associated renal cell carcinoma ( -RCC) accounts for up to 5% adults and 40% of childhood RCC. Their comprehensive immunohistochemical (IHC) profile in correlation fluorescence situ hybridization (FISH) testing their role the diagnostic approach are not well documented because lacking published data. FISH confirmed TFE3- RCC between years 2010 2020 were identified from institutional electronic database retrospectively reviewed. Eighty-five -RCC identified. Seventy-six 85 (89.4%)...
Primary lung cancer is the most common cause of cancer-related mortality in United States (US). Approximately 90% cancers are associated with smoking and use other tobacco products. Based on histology, divided into small-cell carcinomas (SCLCs) non-small-cell (NSCLCs). Most SCLCs pure subtype, while rare combined contain elements both morphologies. This study sought to evaluate demographics, clinical factors, molecular abnormalities, treatment approaches, survival outcomes SCLC NSCLCs.Data...
Fine needle aspiration (FNA) is considered an excellent technique for documenting metastatic neuroendocrine tumors (NETs). This study aims to evaluate the accuracy of FNA in diagnosing NETs liver and determining grade origin these metastases.Our laboratory information system was searched from 1997 2016 identify all cases that were sampled by FNA. The cytopathology surgical pathology reports as well patients' electronic medical records reviewed. cytohistologic type NETs, site patient's...
The aim of this study is to compare the diagnostic accuracy endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) versus biopsy for diagnosis gastrointestinal (GI) subepithelial lesions (SELs) using surgical resection as gold standard.All patients who underwent EUS-FNA upper and lower GI SELs over a 10-year period (2010 through 2019) were retrospectively reviewed. medical records all reviewed data extracted from endoscopy, pathology, reports analyzed.In total, 283 with ages ranging...
A 35-year-old woman was referred for a symptomatic liver mass. Diagnostic workup detected septated cyst located centrally in the measuring 10 × 7 cm. The had gradually increased size from previous studies with new intrahepatic biliary dilation. Due to concern malignancy and presentation of patient, partial central hepatectomy performed. Pathology revealed smooth-walled, multiloculated lined mucinous epithelium ovarian-type stroma. diagnosis low-grade cystic neoplasm (MCN-L) made....
Neuroendocrine carcinomas of the gallbladder (NECs-GB) are rare tumors, accounting for <0.2% all neuroendocrine gastrointestinal tract. They originate from cells epithelium with associated intestinal or gastric metaplasia. The current study is largest SEER database on NECs-GB that aims to elucidate demographic, clinical, and pathologic factors influencing prognosis comparative survival analysis different treatment modalities.The data 176 patients was abstracted Surveillance Epidemiology End...
Abstract Objectives Recent data on hepatic histopathology in patients with sickle cell disease (SCD) are lacking. Methods A total of 39 liver biopsies from SCD 4 medical institutes were systematically evaluated. Results The average age was 27 years; 23 female. majority the had hemoglobin SS (33), 3 SC, and trait. Elevated functional tests evaluation for cirrhosis main indications biopsy. At time biopsy, most elevated transaminases or hepatomegaly. common histopathologic abnormalities Kupffer...
Context. Primary renal mesenchymal neoplasms are rare but diverse. Several of derivation can arise as a primary mass; however, incidental tumors identified in nephrectomies performed for end-stage disease or other malignant epithelial neoplasms. In this article, we document their frequencies with demographic information nephrectomy specimens. Design. We retrospectively searched our database specimens from the year 2000 to 2016. Results. A total 224 cases were an incidence rate 4.4%...