A5077642249- Neurofibromatosis and Schwannoma Cases
- Peptidase Inhibition and Analysis
- Cancer Research and Treatments
- Protein Degradation and Inhibitors
- Sarcoma Diagnosis and Treatment
- Tissue Engineering and Regenerative Medicine
- Musculoskeletal synovial abnormalities and treatments
- T-cell and B-cell Immunology
- Bone Tumor Diagnosis and Treatments
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Tumors and Oncological Cases
- Cancer, Lipids, and Metabolism
- Soft tissue tumor case studies
- Cancer Mechanisms and Therapy
- Neuroblastoma Research and Treatments
- Autoimmune Bullous Skin Diseases
- Nerve injury and regeneration
- Systemic Lupus Erythematosus Research
- Surface Treatment and Residual Stress
- Glioma Diagnosis and Treatment
- Nerve Injury and Rehabilitation
- Immune Cell Function and Interaction
- Histiocytic Disorders and Treatments
Indiana University School of Medicine
2023-2025
Indiana University – Purdue University Indianapolis
2023-2025
Mayo Clinic in Arizona
2023-2025
Indiana University Hospital
2024-2025
Mayo Clinic
2023-2024
Indiana University Health
2024
Washington University in St. Louis
2020-2023
WinnMed
2023
Sinai Hospital
2022
Mount Sinai Hospital
2022
Bacterial involvement in autoimmunity The composition of the commensal microbiota is known to influence autoimmune disease development and persistence. Manfredo Vieira et al. identified a gut microbe, Enterococcus gallinarum , that translocates from into organs mice with genetic predisposition lupus-like (see Perspective by Citi). Molecular signatures barrier disintegration pathogenic T helper cells were evident gut, liver, lymphoid during colonization pathobiont. ensuing pathology could be...
Commensal bacterial orthologs of the human autoantigen Ro60 may trigger cross-reactive T and B cells that initiate sustain chronic autoimmunity in lupus.
BackgroundChronic pruritus, or itch, is common and debilitating, but the neuroimmune mechanisms that drive chronic itch are only starting to be elucidated. Recent studies demonstrate IL-33 receptor (IL-33R) expressed by sensory neurons. However, whether neuron–restricted activity of necessary for remains poorly understood.ObjectivesWe sought determine if signaling in neurons critical development 2 divergent pruritic disease models.MethodsPlasma levels were assessed patients with atopic...
Vascular neoplasms with epithelioid cytomorphology encompass a wide spectrum of benign and malignant lesions, including hemangioma (EH), cutaneous angiomatous nodule (CEAN), hemangioendothelioma (EHE), angiosarcoma (EAS). Recently, the first case features harboring TPM3::ALK fusion was reported. Herein, we report 4 additional cases, 1 an alternate TPM4::ALK fusion, expand on clinicopathologic molecular genetic these unusual vascular lesions. Including previously reported case, 5 tumors...
In pemphigus vulgaris, a life-threatening autoimmune skin disease, epidermal blisters are caused by autoantibodies primarily targeting desmosomal cadherins desmoglein 3 (DSG3) and DSG1, leading to loss of keratinocyte cohesion. Due limited insights into disease pathogenesis, current therapy relies on nonspecific long-term immunosuppression. Both direct inhibition DSG transinteraction altered intracellular signaling p38 MAPK likely contribute the cell adhesion. Here, we applied tandem peptide...
One of the most common malignancies affecting adults with Neurofibromatosis type 1 (NF1) is malignant peripheral nerve sheath tumor (MPNST), an aggressive and often fatal sarcoma that commonly arises from benign plexiform neurofibromas. Despite advances in our understanding MPNST pathobiology, there are few effective therapeutic options, no investigational agents have proven successful clinical trials. To further understand genomic heterogeneity MPNST, to generate a preclinical platform...
Abstract Purpose: To investigate the metabolism of synovial sarcoma (SS) and elucidate effect malic enzyme 1 absence on SS redox homeostasis. Experimental Design: ME1 expression was measured in clinical samples, cell lines, tumors from an mouse model. The glucose evaluated utilizing Seahorse assays, metabolomics, C13 tracings. impact homeostasis by death assays with inhibitors antioxidant systems, measurements intracellular reactive oxygen species (ROS). susceptibility ME1-null to...
Abstract Purpose: Malignant peripheral nerve sheath tumors (MPNST) are aggressive sarcomas with limited treatment options and poor survival rates. About half of MPNST cases associated the neurofibromatosis type 1 (NF1) cancer predisposition syndrome. Overexpression TYK2 occurs in majority MPNST, implicating as a therapeutic target. Experimental Design: The effects pharmacologic inhibition on cell proliferation were examined using IncuCyte live assays vitro, downstream actions analyzed...
Abstract Purpose: Argininosuccinate Synthetase 1 (ASS1) silencing in carcinomas and sarcomas leads to a dependence on extracellular arginine for survival. Arginine deprivation therapies, like PEGylated deiminase (ADI-PEG20), have shown limited effectiveness, which may be due underlying mechanisms that inhibit apoptosis. Experimental Design: The effects of ADI-PEG20 cell cycle regulation, apoptosis, Bcl-xL-mediated survival pathways ASS1-deficient cancer cells were determined. mechanism death...
ABSTRACT Hybrid peripheral nerve sheath tumors (PNSTs) are benign that show features of more than one type PNST. Benign cutaneous plexiform hybrid tumor perineurioma and cellular neurothekeoma (BCPHTPCN) is a rare, recently described entity shows various combinations histomorphologic immunophenotypic the PNSTs neurothekeoma. Our case describes middle‐aged man initially presenting with an acute papulopustular rosacea flare. Rosacea treatment unmasked prominent erythematous papule on forehead....
Perivascular epithelioid cell tumors (PEComas) are a diverse group of mesenchymal neoplasms. While they have been described throughout the genitourinary system, PEComas quite rare within bladder. We present case 37-year-old male who presented in clot retention and was found to bladder PEComa. Staging images seemingly demonstrated solid tumor confinement pelvis. Intraoperative pathology revealed peritoneal metastasis. The patient underwent pelvic mass excision partial cystectomy. had plans...
ABSTRACT Background Genomic fusions involving Protein Kinase C ( PKC or PRKC ) have been classically identified in a subset of melanocytic neoplasms with heavy melanin pigmentation as described older series. They were recently reclassified from the pigmented epithelioid melanocytoma (PEM) category to blue nevus (BN) fifth edition World Health Organization (WHO) Classification Skin Tumors. Methods Herein, we report series eight mostly hypopigmented fusion tumors novel comprehensive molecular...