Despite significant advances in their molecular pathogenesis, skeletal vascular tumors remain diagnostically challenging due to aggressive radiologic appearance and morphologic overlap. Within the epithelioid category at benign end of spectrum, recurrent FOS/FOSB fusions have defined most hemangiomas, distinguishing them from hemangioendothelioma angiosarcoma. More recently, presence EWSR1/FUS :: NFATC1/2 emerged as genetic hallmark a novel group unusual proliferations, often displaying...

Background: Concerns for missed diagnoses have led to increased ordering of diagnostic imaging. Patients with suspected musculoskeletal tumors may undergo nondiagnostic and unnecessary imaging studies before referral a oncologist. This can result in patients receiving excessive radiation exposures, accruing costs, delays treatment, an burden on healthcare systems. Purpose: The purposes this study were (1) internally rate the usefulness tests completed oncology undergoing evaluation using...

Ossifying fibromyxoid tumor (OFMT) is a rare enigmatic of uncertain differentiation that can be classified as typical, atypical, and malignant subtypes based on cellularity, nuclear grade, mitotic activity. The majority OFMTs, regardless the risk malignancy, harbor genetic translocations. We report two including one with evidence dedifferentiation, novel genefusions.

Pancreatic cancer is typically arises in the context of inflammation, and a surrounding area pancreatitis often present within tumor microenvironment. Signet ring cell carcinoma (SRCC) rare variant pancreatic adenocarcinoma. Pathologically, it presents either as single cells or loose clusters masquerading background pancreatitis. Sampling these inflammatory during biopsy can result incorrect diagnosis We report case SRCC pancreas which was delayed because multiple biopsies revealed only...

Hamartomas are considered a mixture of nonneoplastic tissue, which may be indigenous to different location in the body. As such, they epithelial, mesenchymal, or mixed. In sinonasal region, following hamartomatous lesions lie on spectrum and include respiratory epithelial adenomatoid hamartoma (REAH), chondro-osseous (COREAH), nasal chondromesenchymal (NCMH). To our knowledge, less than 50 cases hamartomas have been reported English literature so far with NCMH being very rare primarily tumor...

Low-grade fibromyxoid sarcoma, also known as Evans tumor, is a low-grade sarcoma that most commonly arises in the deep soft tissue of proximal extremities or trunk young adults. It very rare viscera primary site, with only few cases reported literature. Here, we present case tumor occurring an unusual and rarely location; intrathoracic mass arising from diaphragmatic pleura.

Superficial anaplastic lymphoma kinase (ALK)-rearranged myxoid spindle cell neoplasm (SAMS) is a recently described entity which coexpresses ALK, CD34, and commonly S100. These neoplasms are characterized morphologically by concentric whorls cords set in an abundant to myxocollagenous stroma, thus mimicking perineurioma or hybrid nerve sheath tumor. EMA immunostain has been reported be negative SAMS helps excluding the latter entities. Herein, we report first EMA-positive of right leg...

Clear cell variant of epithelioid mesothelioma is an extremely rare tumor with only isolated cases reported so far in the peritoneum. Here, we report a case peritoneal mesothelioma, clear variant, 63-year-old female patient novel VHL gene mutation and unusual indolent clinical course. The patient, who has no history asbestos exposure, presented 27.2-cm upper abdominal mass 5.5-cm liver lesion. Retrospective review patient's computed tomographic scan 4 years ago showed 2 small lesions that...

Objective . Secretory carcinoma is a recently described entity with characteristic immunoprofile and ETV6 (12p13) rearrangement. Before its initial description, it was generally diagnosed as acinic cell (ACCi). We evaluated rearrangement in cytological surgical cases of previously ACCi, an attempt to identify any misclassified SC. Methods Fifteen cytology ACCi over 13-year period were retrieved subjected immunohistochemistry for S-100, mammaglobin, GATA-3 DOG-1 well FISH (12p13). Results Of...

Abstract: Sarcomatoid carcinoma is a rare and aggressive form that occur at diverse locations in the body such as upper respiratory tract, lower digestive tracts, genitourinary breast thyroid glands. However, its occurrence pancreas has been rarely reported. of (SCP) high-grade epithelial malignancy composed predominantly spindle cells often having features suggestive derivation without indicative specific line mesenchymal differentiation. Its pathogenesis not elucidated. Microscopically,...

Abstract Background Anaplastic lymphoma kinase (ALK)‐positive anaplastic large cell (ALCL) shows 60–70% event free survival with standard treatments. Targeted therapies are being tested for increased benefit and/or reduced toxicity, but interactions agents not well known. Methods We exposed four ALCL lines to two targeted agents, crizotinib and brentuximab vedotin, doxorubicin vinblastine. For each agent combination, we measured apoptosis expression of approximately 300 previously annotated...

Primary effusion lymphoma (PEL) is a rare condition, which accounts for approximately 4% of all human immunodeficiency virus (HIV)-associated non-Hodgkin lymphomas. PEL has predilection body cavities and occurs in the pleural space, pericardium, peritoneum. Without treatment, median survival 2-3 months, with chemotherapy, 6 months. We describe case 47-year-old male HIV Kaposi's sarcoma who presented complaints abdominal pain distension was subsequently diagnosed PEL. Despite limited clinical...

Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor most commonly seen in young adults and children. We report case with morphology immunohistochemistry supporting the diagnosis of synovial sarcoma. On core biopsy, had spindle cell epithelioid myxoid background. Staining for transducin-like enhancer split 1 CD99 were positive; however, subsequent fluorescence situ hybridization SYT (SS18, nBAF chromatin remodeling complex subunit) break apart returned negative. Further study...

Alveolar soft part sarcoma is a rare malignant tissue tumor, mainly localized in the extremities and occurring principally adolescents young adults. are uncommon female genital tract. We here report case of alveolar 20-year-old nullipara, presenting with vaginal bleeding profound anemia requiring blood transfusions. Ultrasonographic examination revealed polyp lower uterine segment. Surgical resection was performed, pathological evaluation showed typical histological, immunohistochemical,...

Abstract Ossifying fibromyxoid tumor (OFMT) is a rare soft tissue neoplasm of uncertain differentiation that has the capacity for local recurrence and metastasis. Many OFMTs, including typical, atypical, malignant tumors, have demonstrated recurrent gene fusions. The fusion partners reported to date share common core function in they play either direct or indirect role processes influencing histone modification. Herein, we report an OFMT with unusual morphology non‐specific immunoprofile...

Chronic myeloid leukemia (CML) is a hematologic malignancy associated with increased circulating cells and platelets in the peripheral blood, accompanying bone marrow hyperplasia. The Philadelphia chromosome, t(9;22)(q34;q11), present 95% of CML patients, resulting constitutive tyrosine kinase activity; however, ~5% patients possess variant. A novel three‑way translocation variant, t(9;22;17)(q34;q11.2;q11.2), was identified 54‑year old man who presented leukocytosis, anemia thrombocytosis...

Metastatic carcinomas to the uterus are rare and usually originate from nearby gynecologic sites, most commonly ovaries. Among non-gynecologic origins, breast tumors frequent primaries, predominantly lobular carcinoma type. A 69-year-old postmenopausal woman diagnosed with 5 years ago, status post modified radical mastectomy, currently on tamoxifen therapy presented post-menopausal bleeding. Subsequent endometrial biopsy confirmed diagnosis of metastatic endometrium. Breast rarely...

Myoepithelial tumors of soft tissue are rare mesenchymal neoplasms that overlap with their salivary gland and skin counterparts at both the histopathologic molecular levels. EWSR1 gene rearrangements various fusion partners represent a common genetic event in myoepithelial tissue, whether benign or malignant, may prove useful as diagnostic tool difficult cases. However, number entities has grown considerably recent years, there is significant morphologic immunophenotypic amongst this group,...