A5081077123- Renal cell carcinoma treatment
- Peroxisome Proliferator-Activated Receptors
- Eicosanoids and Hypertension Pharmacology
- Cancer, Lipids, and Metabolism
- Renal and related cancers
- Bladder and Urothelial Cancer Treatments
- Cancer Genomics and Diagnostics
- Sarcoma Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Urinary and Genital Oncology Studies
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Bone Tumor Diagnosis and Treatments
- Adrenal and Paraganglionic Tumors
- Prostate Cancer Diagnosis and Treatment
- Tuberous Sclerosis Complex Research
- Acute Myeloid Leukemia Research
- Neuroblastoma Research and Treatments
- Tumors and Oncological Cases
- Glioma Diagnosis and Treatment
- Urologic and reproductive health conditions
- Salivary Gland Tumors Diagnosis and Treatment
- Testicular diseases and treatments
- Thyroid Cancer Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
Johns Hopkins Medicine
2009-2025
Johns Hopkins University
2007-2025
Johns Hopkins Hospital
2022-2025
University of Baltimore
2023-2024
Hospital of the University of Pennsylvania
2018-2020
University of Pennsylvania
2008-2020
Yale University
2013-2017
TU Dresden
2015
Yonsei University
2008
John Radcliffe Hospital
2008
Since their original description as a distinctive neoplastic entity, ~50 TFE3 -rearranged perivascular epithelioid cell tumors (PEComas) have been reported. We herein report 25 new PEComas and review the published literature to further investigate clinicopathologic spectrum. Notably, 5 of cases were associated with prior history chemotherapy treatment for cancer. This is in keeping reports, based mainly on small case series, overall 11% being diagnosed postchemotherapy. The median age our...
Oxidized low-density lipoproteins increase arginase activity and reciprocally decrease endothelial NO in human aortic cells. Here, we demonstrate that vascular is increased atherogenic-prone apolipoprotein E–null (ApoE −/− ) wild-type mice fed a high cholesterol diet. In ApoE mice, selective II inhibition or deletion of the gene (Arg mice) prevents high-cholesterol diet–dependent decreases production, reactive oxygen species restores function, oxidized lipoprotein–dependent increases...
Abstract Brain metastasis, the most lethal form of melanoma and carcinoma, is consequence favorable interactions between invading cancer cells brain cells. Peroxisome proliferator–activated receptor γ (PPARγ) has ambiguous functions in development, its relevance advanced metastasis remains unclear. Here, we demonstrate that astrocytes, unique glial cells, activate PPARγ metastatic activation enhances cell proliferation outgrowth brain. Mechanistically, astrocytes have a high content...
ABSTRACT Background The Nectin‐4 directed antibody drug conjugate enfortumab vedotin (EV) has emerged as frontline systemic therapy in combination with immune checkpoint blockade for urothelial carcinoma (UC), capitalizing on the ubiquitous expression of this protein UC. There is limited data available regarding by immunohistochemistry prostate cancer, but interest a substantial number UC patients likely to receive EV have concomitant cancer. Methods was evaluated tissue microarrays...
Abstract Enhancer of zeste homolog 2 (EZH2) is an essential epigenetic regulator H3K27 histone methylation and mutated or overexpressed in a wide variety cancers. In melanoma, EZH2 overexpression contributes to excessive trimethylation on tumor suppressor genes has been proposed be mechanism progression metastasis. EZH2-targeted therapies have successfully used treat patients with follicular lymphoma epithelioid sarcoma, but their clinical use melanoma not described. Here, we describe...
Abstract Purpose The Pheochromocytoma of the Adrenal Gland Scaled Score (PASS) and Grading System for Paraganglioma (GAPP) are scoring systems to predict metastatic potential in pheochromocytomas (PCC) paragangliomas (PGLs). goal this study is assess PASS GAPP as predictors correlate with survival outcomes. Methods cohort included PCC/PGL ≥5 years follow-up or known metastases. Surgical pathology slides were rereviewed. scores assigned. Univariable multivariable logistic regression,...
With a rapidly developing immunotherapeutic landscape for patients with metastatic clear cell renal carcinoma, biomarkers of efficacy are highly desirable to guide treatment strategy. Hematoxylin and eosin (H&E)-stained slides inexpensive widely available in pathology laboratories, including resource-poor settings. Here, H&E scoring tumor-infiltrating immune cells (TILplus) pre-treatment tumor specimens using light microscopy is associated improved overall survival (OS) three independent...
Summary Rosai‐Dorfman disease (RDD) is an enigmatic histiocytic disorder classically diagnosed by a distinctive combination of pathological features: emperipolesis, or migration intact haematological cells through the voluminous cytoplasm lesional histiocytes, and expression S100 these histiocytes. The pathogenesis has long been elusive until recent detection recurrent mutually exclusive mutations in several oncogenes mitogen‐activated protein kinase (MAPK) pathway. Based on findings, we...
Background and Objectives: CD276 (B7-H3) has recently emerged as a promising presumptive immune checkpoint inhibitor (ICI) potential antibody-drug conjugate (ADC) target for prostate cancer (PCa). We evaluated B7-H3 15 other clinically relevant ADC ICI targets expression at the RNA protein level across PCa continuum - hormone-sensitive, castration-resistant, neuroendocrine. Methods: CCLE data analysis western blot experiments were performed quantifying variability cell lines. Inter-...
Metastatic translocation renal cell carcinomas (mtRCCs) are rare and aggressive tumors with limited treatment options. Recent studies demonstrated promising activity of immune-oncology (IO) combinations in mtRCC. However, the effectiveness dual IO versus plus VEGF-TKI remains unclear. We conducted a retrospective analysis mtRCC patients at 4 institutions. Eligible had confirmed by genitourinary pathologist received combination therapy (IO+IO or IO+VEGF-TKI). Clinical data outcomes were...
Abstract Self-reported Black (B) individuals remain underrepresented in molecular studies of clear cell renal carcinoma (ccRCC) relative to White (W) individuals. We performed whole-exome and transcriptome sequencing on paired tumor normal samples from 59 matched B W patients undergoing nephrectomy for localized ccRCC, comparing differences by estimated genetic similarity African (AFR) European (EUR) 1000 Genomes groups. validated our findings with a propensity-matched subset TCGA, yielding...
Primitive sarcomas harboring the MEIS1::NCOA2 gene fusion were originally described in kidney 2018, and subsequently reported other organs. These variably cellular neoplasms feature monomorphic primitive plump spindle cells forming nodules whorls addition to nondescript fascicular, solid, storiform patterns. They lack skeletal muscle differentiation contrast primarily intraosseous rhabdomyosarcomas that harbor same fusion. We describe 7 new primary renal with MEIS1::NCOA1 fusions. Although...