A5019624200- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cerebrovascular and Carotid Artery Diseases
- Cardiac pacing and defibrillation studies
- Peripheral Artery Disease Management
- Cardiovascular Health and Disease Prevention
- Acute Kidney Injury Research
- Acute Ischemic Stroke Management
- Vascular Procedures and Complications
- Cardiac Valve Diseases and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Nitric Oxide and Endothelin Effects
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Health and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Lipoproteins and Cardiovascular Health
- Trypanosoma species research and implications
- Cardiac Health and Mental Health
- Trauma and Emergency Care Studies
- Cardiac Arrhythmias and Treatments
- Cardiomyopathy and Myosin Studies
New York University
2019
Ochsner Medical Center
2013-2017
College of Family Physicians of Canada
2017
Creative Commons
2017
St. Luke's-Roosevelt Hospital Center
2010-2016
Universidade de São Paulo
2009-2016
Arizona Heart Institute
2016
Henry Ford Hospital
2015
Sir H.N. Reliance Foundation Hospital and Research Centre
2015
University of Arkansas Medical Center
2015
Oxidized low-density lipoproteins increase arginase activity and reciprocally decrease endothelial NO in human aortic cells. Here, we demonstrate that vascular is increased atherogenic-prone apolipoprotein E–null (ApoE −/− ) wild-type mice fed a high cholesterol diet. In ApoE mice, selective II inhibition or deletion of the gene (Arg mice) prevents high-cholesterol diet–dependent decreases production, reactive oxygen species restores function, oxidized lipoprotein–dependent increases...
Endothelial dysfunction and increased arterial stiffness contribute to multiple vascular diseases are hallmarks of cardiovascular aging. To investigate the effects aging on shear stress-induced endothelial nitric oxide (NO) signaling aortic stiffness, we studied young (3–4 mo) old (22–24 rats in vivo vitro. Old rat aorta demonstrated impaired vasorelaxation acetylcholine sphingosine 1-phosphate, while responses sodium nitroprusside were similar those aorta. In a customized flow chamber,...
Background Dual antiplatelet therapy is the standard of care after coronary stent placement but increases bleeding risk. The effects proton pump inhibitors (PPIs) on clopidogrel metabolism have been described, clinical significance not yet definitive. We aimed to do an updated meta-analysis comparing outcomes in patients receiving with and without PPIs. Methods systematically searched PubMed, Scopus Cochrane Central Register Controlled Trials for randomised controlled trials (RCTs)...
The epidemiology of dialysis requiring acute kidney injury (AKI-D) in ischemic stroke (AIS) and intracerebral hemorrhage (ICH) admissions is poorly understood with previous studies being from a single center or year.We used the Nationwide Inpatient Sample to evaluate yearly incidence trends AKI-D hospitalizations AIS ICH 2002 2011. We also evaluated trend impact on in-hospital mortality adverse discharge using adjusted odds ratios (aOR) after adjusting for demographics comorbidity indices.We...
Chronologic age is a strong predictor of adverse outcomes after cardiac surgery. The variability in age-related cardiovascular changes suggests that may not be the most accurate perioperative outcomes. Vascular stiffness has emerged as an important surrogate vascular aging. In retrospective review, we investigated value stiffness, assessed by brachial pulse pressure (PP) measurements, predicting stroke 703 patients (63.4% men and 36.6% women). Patients were followed for 348+/-215 days We...
We hypothesize that minimally invasive valve surgery in patients with chronic obstructive pulmonary disease (COPD) is superior to the conventional median sternotomy approach. retrospectively reviewed 2846 consecutive performed at our institution between January 2005 and September 2010, identified 165 COPD who underwent isolated surgery. In-hospital mortality, composite complication rates, intensive care unit total hospital length of stay those had undergone a approach were compared cohort...
Background Contrast-induced nephropathy (CIN) is the third most common cause of hospital-acquired kidney injury and related to increased long-term morbidity mortality. Adequate intravenous (IV) hydration has been demonstrated lessen its occurrence. Oral (PO) with water inexpensive readily available but role for CIN prevention yet be determined. Methods PubMed, EMBASE Cochrane Central register controlled trials (CENTRAL) databases were searched until April 2015 studies selected using...
To compare the metabolic, hemodynamic, autonomic, and endothelial responses to short-term red wine consumption in subjects with hypercholesterolemia or arterial hypertension, healthy controls. Subjects (n=10) hypertension (n=9), controls (n=7) were given (250 mL/night) for 15 days. Analyses performed before after intake. Red significantly increased plasma levels of HDL-cholesterol controls, but not other groups. The effects on hemodynamic measurements mild, non-significantly more prominent...
The objective of this study was to describe the incidence acute kidney injury (AKI) requiring renal replacement therapy ('dialysis-requiring AKI') and impact on in-hospital mortality among hospitalized adults with HIV infection.A longitudinal analysis a nationally representative administrative database.We reviewed Healthcare Cost Utilization Project's Nationwide Inpatient Sample Database, large, sample inpatient hospital admissions, identify all adult hospitalizations an associated diagnosis...
We sought to ascertain predictors of Patient Prosthesis Mismatch, an independent predictor mortality, in patients with aortic stenosis using bioprosthetic valves.We analyzed 2,107 sequential surgeries. Mismatch was calculated the effective orifice area prosthesis divided by patient's body surface area. defined nonsignificant, moderate, and severe as indexes .0.85 cm(2)/m, 0.85-0.66 cm(2)/m(2), <0.65 respectively.A total 311 were identified. The incidence 41%, 42, 16%, respectively. Severe...
Background Cilostazol is an oral antiplatelet agent currently indicated for treatment of intermittent claudication. There evidence that cilostazol may reduce femoropopliteal restenosis after percutaneous endovascular intervention. Methods We searched PubMed, Scopus and Cochrane databases from 1966 through September 2013 randomised controlled trials (RCTs) evaluating the addition to standard care in patients receiving treatment. Restenosis, target lesion revascularisation combined adverse...