A5059536506- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Cell death mechanisms and regulation
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Ferroptosis and cancer prognosis
- Ubiquitin and proteasome pathways
- Immune cells in cancer
- Cancer-related Molecular Pathways
- Pancreatic and Hepatic Oncology Research
- Signaling Pathways in Disease
- Cancer, Lipids, and Metabolism
- Esophageal Cancer Research and Treatment
- Angiogenesis and VEGF in Cancer
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Peptidase Inhibition and Analysis
- Cancer Cells and Metastasis
- Galectins and Cancer Biology
- NF-κB Signaling Pathways
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
Johns Hopkins University
2016-2025
Sidney Kimmel Comprehensive Cancer Center
2021-2025
Cancer Institute (WIA)
2018-2025
Johns Hopkins Medicine
2017-2025
University of Baltimore
2017-2024
The University of Texas MD Anderson Cancer Center
2011-2024
Bladder Cancer Advocacy Network
2016-2024
Johns Hopkins Hospital
2023-2024
Sidney Kimmel Cancer Center
2024
Rice University
2024
Urothelial carcinoma of the bladder is a common malignancy that causes approximately 150,000 deaths per year worldwide. So far, no molecularly targeted agents have been approved for treatment disease. As part The Cancer Genome Atlas project, we report here an integrated analysis 131 urothelial carcinomas to provide comprehensive landscape molecular alterations. There were statistically significant recurrent mutations in 32 genes, including multiple genes involved cell-cycle regulation,...
A better understanding of drug resistance mechanisms is required to improve outcomes in patients with pancreatic cancer. Here, we characterized patterns sensitivity and three conventional chemotherapeutic agents divergent action [gemcitabine, 5-fluorouracil (5-FU), cisplatin] cancer cells. Four (L3.6pl, BxPC-3, CFPAC-1, SU86.86) were sensitive five (PANC-1, Hs766T, AsPC-1, MIAPaCa-2, MPanc96) resistant all based on GI(50) (50% growth inhibition). Gene expression profiling unsupervised...
Cytotoxic chemotherapy targets elements common to all nucleated human cells, such as DNA and microtubules, yet it selectively kills tumor cells. Here we show that clinical response these drugs correlates with, may be partially governed by, the pretreatment proximity of cell mitochondria apoptotic threshold, a property called mitochondrial priming. We used BH3 profiling measure priming in cells from patients with multiple myeloma, acute myelogenous lymphoblastic leukemia, ovarian cancer. This...
Glucocorticoid hormones kill immature thymocytes by activating a self-destructive process that involves extensive DNA fragmentation. It has been demonstrated thymocyte suicide is dependent on an early, sustained increase in cytosolic Ca2+ concentration, and new protein synthesis, but the biochemical lesion leads to cell death not established. To determine whether endonuclease activation or of another Ca2+-de-pendent could mediate killing, we treated with glucocorticoid methylprednisolone...
Suspensions of thymocytes from young rats were incubated with 2,3,7,8- tetrachlorodibenzo- p -dioxin (TCDD), which resulted in a sustained increase cytosolic free Ca 2+ concentration followed by DNA fragmentation and loss cell viability. Both the prevented cells treated inhibitor protein synthesis, cycloheximide, killing not detected when "Ca -free" medium or pretreated high concentrations calcium probe, quin-2 tetraacetoxymethyl ester. These results indicate that TCDD can kill immature...
The epithelial-to-mesenchymal transition (EMT) is a cell development-regulated process in which noncoding RNAs act as crucial modulators. Recent studies have implied that EMT may contribute to resistance epidermal growth factor receptor (EGFR)-directed therapy. aims of this study were determine the potential role microRNAs (miRNA) controlling and inducing sensitivity human bladder cancer cells inhibitory effects anti-EGFR therapy.miRNA array screening real-time reverse transcription-PCR used...
Multiple studies in recent years have identified highly tumorigenic populations of cells that drive tumor formation. These cancer stem (CSCs), or tumor-initiating (TICs), exhibit properties normal and are associated with resistance to current therapies. As pancreatic adenocarcinoma is among the most resistant human cancers chemo-radiation therapy, we sought evaluate presence cell capacities tumors. Understanding which possess capabilities critical characterizing understanding biology CSCs...
The advent of Omics technologies has been key to the molecular subclassification urothelial bladder cancer. Several groups have used different strategies this aim, with partially overlapping findings. meeting at Spanish National Cancer Research Center-CNIO was held discuss such classifications and reach consensus where appropriate. After updated presentations on work performed by teams attending meeting, a reached regarding existence group Basal-Squamous-like tumors - designated BASQ...