A5040152817- Acute Myeloid Leukemia Research
- Hematological disorders and diagnostics
- Hemoglobinopathies and Related Disorders
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Histiocytic Disorders and Treatments
- Eosinophilic Disorders and Syndromes
- Medical Education and Admissions
- Hematopoietic Stem Cell Transplantation
- Viral-associated cancers and disorders
- Blood disorders and treatments
- Diversity and Career in Medicine
- Iron Metabolism and Disorders
- Innovations in Medical Education
- Immunodeficiency and Autoimmune Disorders
- Sarcoma Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Kawasaki Disease and Coronary Complications
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cardiac tumors and thrombi
- Vascular Tumors and Angiosarcomas
- Mycobacterium research and diagnosis
- Mesenchymal stem cell research
- Monoclonal and Polyclonal Antibodies Research
- Erythropoietin and Anemia Treatment
Cincinnati Children's Hospital Medical Center
2019-2025
University of Cincinnati Medical Center
2022-2025
Wake Forest University
2008-2019
University of Cincinnati
2019
Atrium Health Wake Forest Baptist
2013-2018
Seattle University
2016
University of Florida
2003-2012
Florida College
2004-2012
Winston-Salem State University
2012
Abstract ALK-positive histiocytosis is a rare subtype of histiocytic neoplasm first described in 2008 3 infants with multisystemic disease involving the liver and hematopoietic system. This entity has subsequently been documented case reports series to occupy wider clinicopathologic spectrum recurrent KIF5B-ALK fusions. The full molecular spectra remain, however, poorly characterized. Here, we describe largest study date, detailed data 39 cases, including 37 cases confirmed ALK...
Multisystem inflammatory syndrome in children (MIS-C) is a potentially life-threatening hyperinflammatory that occurs after primary SARS-CoV-2 infection. The pathogenesis of MIS-C remains undefined, and whether specific biomarker patterns can distinguish from other syndromes, including Kawasaki disease macrophage activation (MAS), unknown. Therefore, we aimed to investigate biomarkers could be used between these conditions.We studied prospective cohort patients with an established new-onset...
Adenoid cystic/basal cell carcinoma (ACBCC) of the prostate has been considered to have indolent biologic potential. However, outcome data are scant, with only one documented metastasis and death. We describe clinicopathologic features ACBCC in 19 patients document 15. Patients ranged age from 43 83 years. All but presented urinary obstruction. was diagnosed by transurethral resection 15 cases, needle biopsy 3 unexpected 1 case. Four had concurrent acinar adenocarcinoma. Histologically,...
Extremely short telomeres in patients with dyskeratosis congenita and related telomere biology disorders (TBDs) lead to premature cellular senescence bone marrow failure. Zinc finger SCAN domain-containing 4 (ZSCAN4) elongates by recombination. We report a clinical study which EXG34217, the term given for autologous CD34+ hematopoietic stem cells from TBD exposed temperature-sensitive Sendai virus vector encoding human ZSCAN4 at 33°C 24 hours, was infused into without preconditioning. Four...
Current bone marrow dosimetry methods inherently assume that the target cells of interest for assessment leukemia risk (stochastic effects) or toxicity (deterministic are uniformly localized throughout cavities cancellous bone. Previous studies on mouse femur, however, have demonstrated a spatial gradient hematopoietic stem and progenitor cells, with higher concentrations near surfaces. The objective present study was to directly measure concentration these as well vasculature structures,...
Macrophages play a critical role in iron homeostasis by recycling from red cells and storing it ferritin, an storage protein. The recycled is delivered to erythroid precursors for erythropoiesis. In this study, we aimed determine whether ferritin highly expressed macrophages precursors, can be used as marker these two cell types.A monoclonal antibody was developed, immunohistochemistry performed. normal bone marrows, stained early macrophages. contrast, myeloid cells, lymphoid megakaryocytes...
Sinus histiocytosis with massive lymphadenopathy (SHML), also known as Rosai-Dorfman disease, is a rare self-limiting disorder of histiocytes unknown etiology. most common in children and young adults characterized by painless lymphadenopathy. Histologically there proliferation sinus lymphophagocytosis or emperipolesis. On occasions, SHML has been associated lymphoma, usually involving different anatomic sites developing at times. We report case concomitant nodal marginal zone lymphoma the...
Sinus histiocytosis with massive lymphadenopathy (SHML), also known as Rosai-Dorfman disease, is a rare self-limiting disorder of histiocytes unknown etiology. most common in children and young adults characterized by painless lymphadenopathy. Histologically there proliferation sinus lymphophagocytosis or emperipolesis. On occasions, SHML has been associated lymphoma, usually involving different anatomic sites developing at times. We report case concomitant nodal marginal zone lymphoma the...
We report the rare occurrence of donor-derived myeloid sarcoma in two kidney transplant patients who received organs from a single deceased donor. There was no evidence preexisting hematologic malignancy donor at time organ recovery. Both recipients developed leukemic involvement that appeared to be limited transplanted organ. Fluorescence situ hybridization (FISH) and molecular genotyping analyses confirmed malignant cells were origin each patient. Allograft nephrectomy immediate withdrawal...
Abstract This study was a retrospective evaluation of the use technetium-99m hexamethylpropyleneamineoxime (HMPAO) labelled leucocytes in investigation suspected inflammatory bowel disease children. The images were analysed 35 children and findings compared with results endoscopy/biopsy, barium studies antinuclear cytoplasm antibody (ANCA) serology. sensitivity white cell scan 83% specificity 81%. compares well other adults is superior to investigations. technique recommended as first line...
Abstract SRP54 mutations have recently been implicated in congenital neutropenia (CN) and the in‐frame deletion, p.Thr117del, is most common pathogenic mutation reported. The largest study of ‐mutated CN to‐date followed 23 patients for a median 15 years. No developed hematologic malignancy that study. Given known risk leukemia other CNs it crucial to know whether with an increased leukemia. We report first case patient CN. A 15‐year‐old male (p.Thr117del) was diagnosed acute myeloid...
A 41-year-old female presented with a 2 d history of ‘refusing to talk’ and 1 ‘decreased movement’. She had recent being treated for otitis media, but no malignancy. On admission, full blood count differential white cell were normal. Magnetic resonance imaging revealed 6 cm contrast-enhancing left-sided middle cranial fossa mass extension inferiorly into the subtemporal parapharyngeal space (top left). The radiologist’s diagnosis included meningeal sarcoma, atypical meningioma,...
Juvenile xanthogranulomatosis (JXG) is a rare benign condition, which usually presents with characteristic skin lesions and can be diagnosed clinically. However, systemic JXG may involve wide range of extracutaneous sites pose diagnostic dilemma for the clinician, radiologist, pathologist. In particular it simulate malignancy. Here, we report case within abdominal wall musculature lungs, imitated sarcoma pulmonary metastases on computerized tomography. To best our knowledge, this first such...
Testicular relapse of acute myeloid leukemia without bone marrow involvement is a rare event. We describe case an 18-year-old male who had isolated testicular 86 months (7.2 years) from original diagnosis. He was treated with surgery only, adjuvant therapy. The patient then developed central nervous system 9 later. Fluorescence in situ hybridization and immunohistochemistry were used to establish the diagnosis rather than new leukemic process. intrathecal chemotherapy systemic reinduction,...
Posttransplant lymphoproliferative disorders (PTLD) are a rare, but serious complication following transplantation. Late-onset PTLD often associated with more monoclonal lesions and consequently have worse prognosis. There only isolated case reports of Burkitt's lymphoma presenting as PTLD. We present an extremely aggressive years after kidney pancreas transplantation which was successfully treated combination chemotherapy along withdrawal immunosuppression. The patient remains in complete...
To assess bone marrow (BM) sampling in academic medical centers.Data from 6,374 BM samples obtained 32 centers 2001 and 2011, including core length (CL), were analyzed.BM included a biopsy (BMB; 93%) specimen, aspirate (BMA; 92%) or both (83%). The median (SD) CL was 12 (8.5) mm, evaluable 9 (7.6) mm. Tissue contraction due to processing 15%. BMB specimens longer adults younger than 60 years, men, bilateral, staging, baseline samples. Only 4% of 2% BMB/BMA deemed inadequate for diagnosis....
A 13-year-old boy with a history of vertebral, anus, tracheoesophageal, radial, and renal (VATER) association, including duodenal atresia, tracheal-esophageal fistula, limb malformations, presented to regional emergency department fever, vomiting, mental status changes. Physical examination revealed tachycardia, lethargy, cool extremities, weak peripheral pulses. He was transferred tertiary-care hospital for management possible meningitis septic shock, where admission imaging studies showed...
A 34-year-old female with a 5-year history of cutaneous T-cell lymphoma presented to the emergency department shortness breath, abdominal distention and lower extremity oedema. The peritoneal fluid revealed organisms consistent pneumocystis, which was confirmed by immunofluorescent antibody assay. full blood count showed pancytopenia bone marrow biopsy performed. aspirate smears normal multilineage haematopoiesis focal aggregates foamy eosinophilic material similar in appearance...
A 26-year-old man presented with right upper hip pain. CT scan showed a 6.0 × 7.0 cm3 lytic lesion in the iliac wing significant soft tissue involvement. fine-needle aspiration of revealed numerous atypical plasma cells consistent plasmacytoma. Flow cytometry confirmed diagnosis. radiological bone survey single 7-mm well-defined lucent focus at front aspect lateral skull. By serum protein electrophoresis and immunofixation, patient had an IgG kappa M-spike estimated 2.76 g/dl. marrow biopsy...