A5048887537- Childhood Cancer Survivors' Quality of Life
- Neutropenia and Cancer Infections
- Central Venous Catheters and Hemodialysis
- Palliative Care and End-of-Life Issues
- Antibiotics Pharmacokinetics and Efficacy
- Complement system in diseases
- Ethics and Legal Issues in Pediatric Healthcare
- Bacterial Identification and Susceptibility Testing
- Nausea and vomiting management
- Reproductive Biology and Fertility
- Chromatin Remodeling and Cancer
- Venous Thromboembolism Diagnosis and Management
- Pediatric Pain Management Techniques
- Acute Lymphoblastic Leukemia research
- Sepsis Diagnosis and Treatment
- Blood disorders and treatments
- Hematological disorders and diagnostics
- Oral health in cancer treatment
- Neonatal Respiratory Health Research
- Cancer Mechanisms and Therapy
- Renal and related cancers
- Pharmacological Effects and Toxicity Studies
- Neuroblastoma Research and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Immune Cell Function and Interaction
Princess Máxima Center
2018-2025
Hubrecht Institute for Developmental Biology and Stem Cell Research
2012-2022
Emma Kinderziekenhuis
2012-2021
Amsterdam UMC Location University of Amsterdam
2010-2019
University of Amsterdam
2006-2018
University Medical Center Utrecht
2000-2016
Cancer Genomics Centre
2016
Boston Children's Hospital
2006-2015
Cancer Center Amsterdam
2007
Chris Hani Baragwanath Hospital
2001
Stem cells generate rapidly dividing transit-amplifying that have lost the capacity for self-renewal but cycle a number of times until they exit cell and undergo terminal differentiation. We know very little type signals trigger earliest steps stem differentiation mediate to transition. show in normal intestinal epithelium, endoplasmic reticulum (ER) stress activity unfolded protein response (UPR) are induced at transition from cell. Induction ER causes loss stemness Perk-eIF2α-dependent...
Colorectal cancer (CRC) organoids can be derived from almost all CRC patients and therefore capture the genetic diversity of this disease. We assembled a panel carrying either wild-type or mutant RAS, as well normal tumor with CRISPR-introduced oncogenic KRAS mutation. Using panel, we evaluated RAS pathway inhibitors drug combinations that are currently in clinical trial for cancers. Presence correlated strongly resistance to these targeted therapies. This was observed tumorigenic organoids....
Multipotent stem cells and their lineage-restricted progeny drive nephron formation within the developing kidney. Here, we document expression of adult cell marker Lgr5 in kidney assess stem/progenitor identity Lgr5+ve via vivo lineage tracing. The appearance localization coincided with that S-shaped body around embryonic day 14. remained restricted to clusters nephrons cortex until postnatal 7, when was permanently silenced. In tracing identified as a population nascent dedicated generating...
Abstract STUDY QUESTION Twenty years after the inception of first fertility preservation programme for pre-pubertal boys, what are current international practices with regard to cryopreservation immature testicular tissue? SUMMARY ANSWER Worldwide, tissue has been cryopreserved from over 3000 boys under age 18 a variety malignant and non-malignant indications; there is variability in related eligibility, clinical assessment, storage, funding. WHAT IS KNOWN ALREADY For male patients receiving...
Abstract Background Controversy exists as to what may be defined standard of care (including markers for stratification) patients with atypical teratoid/rhabdoid tumors (ATRTs). The European Rhabdoid Registry (EU-RHAB) recruits uniformly treated and offers standardized genetic DNA methylation analyses. Methods Clinical, genetic, treatment data 143 from 13 countries were analyzed (2009–2017). Therapy consisted surgery, anthracycline-based induction, either radiotherapy or high dose...
Abstract ALK-positive histiocytosis is a rare subtype of histiocytic neoplasm first described in 2008 3 infants with multisystemic disease involving the liver and hematopoietic system. This entity has subsequently been documented case reports series to occupy wider clinicopathologic spectrum recurrent KIF5B-ALK fusions. The full molecular spectra remain, however, poorly characterized. Here, we describe largest study date, detailed data 39 cases, including 37 cases confirmed ALK...
Infection in neutropenic children is a major cause of morbidity and mortality treated for cancer. In developing countries, with cancer are often malnourished at diagnosis. Blantyre, Malawi, Burkitt lymphoma local protocol limited toxicity. The aim this study was to evaluate the incidence outcome febrile neutropenia during treatment association malnutrition diagnosis.We documented nutritional status, and/or episodes, antibiotic therapy short term all according admitted from January 2007 March...
This clinical practice guideline provides recommendations for preventing acute and delayed phase chemotherapy-induced nausea vomiting (CINV) in pediatric patients. The are based on two systematic reviews of randomized controlled trials evaluating interventions to prevent (1) CINV (2) CINV. Recommendations prophylaxis made patients receiving chemotherapy varying emetogenicity, as well not able receive dexamethasone or a neurokinin-1 receptor antagonist. Evidence gaps, including antiemetic...