A5015485580- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- DNA Repair Mechanisms
- Childhood Cancer Survivors' Quality of Life
- Sarcoma Diagnosis and Treatment
- Hedgehog Signaling Pathway Studies
- CRISPR and Genetic Engineering
- Acute Lymphoblastic Leukemia research
- Renal and related cancers
- Neutropenia and Cancer Infections
- Oral health in cancer treatment
- Carcinogens and Genotoxicity Assessment
- Polyomavirus and related diseases
- Organ Transplantation Techniques and Outcomes
- Antifungal resistance and susceptibility
- Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Fungal Infections and Studies
- Lymphoma Diagnosis and Treatment
- Lung Cancer Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Oral and Maxillofacial Pathology
- Cancer-related Molecular Pathways
- Ocular Oncology and Treatments
- Neuroendocrine Tumor Research Advances
Children's Memorial Health Institute
2016-2025
Military Hospital
2024
Wroclaw Medical University
2024
Instytut Matki i Dziecka
2003-2016
Université Grenoble Alpes
2014
Centre Hospitalier Universitaire de Grenoble
2014
Stockholm University
2014
European Medicines Agency
2014
Abstract ALK-positive histiocytosis is a rare subtype of histiocytic neoplasm first described in 2008 3 infants with multisystemic disease involving the liver and hematopoietic system. This entity has subsequently been documented case reports series to occupy wider clinicopathologic spectrum recurrent KIF5B-ALK fusions. The full molecular spectra remain, however, poorly characterized. Here, we describe largest study date, detailed data 39 cases, including 37 cases confirmed ALK...
HCC constitutes 25-30% of primary malignant liver tumors in children. Conventional surgical excision is not possible more than 50% patients. LTx has recently become an important therapeutic option for adults and children with tumors. The aim this study was a retrospective analysis the clinical pathological data treated relation to Milan criteria assessed at diagnosis then immediately before transplantation, comparison group patients conventionally. Between 1990 2007 we have 21 diagnosed HCC....
Due to small number of patients with Nijmegen Breakage Syndrome (NBS) and Non-Hodgkin lymphoma (NHL) experience in their treatment is limited.Since 1996, 17 a median age 9.5 years who had NBS, were treated for NHL. NHL type, stage, chemotherapy, dose modifications, chemotherapy delays, response toxicity, outcome correlation drug reduction analyzed.Nine TNHL, eight BNHL. TNHL received BFM BNHL LMB type protocols. Doses cytostatics reduced the first courses. Further modifications depended on...
Abstract Four molecular types of rare central nervous system (CNS) tumors have been recently identified by gene methylation profiling: CNS Neuroblastoma with FOXR2 activation (CNS NB-FOXR2), Ewing Sarcoma Family Tumor CIC alteration EFT-CIC), high grade neuroepithelial tumor MN1 HGNET-MN1) and BCOR HGNET-BCOR). Although they are not represented in 2016 updated WHO classification tumors, their diagnostic recognition is important because clinical consequences. We introduced a method based on...
PURPOSE Soon after the Russian invasion of Ukraine in February 2022, an initiative was organized to evacuate Ukrainian children with cancer, most initially Poland. This study assessed impact this rapid increase clinical need on Polish system pediatric cancer care. METHODS multicenter longitudinal approach performed among all 19 Pediatric Oncology Centers (PPOCs). We compared PPOC capacity before that during first 11 weeks invasion, using three ratios: patients physicians (PtP), nurses (PtN),...
There is no consensus on optimal treatment duration for propranolol in infantile hemangioma (IH). We evaluated the efficacy and safety of oral solution administered a minimum 6 months up to maximum 12 age high-risk IH.This single-arm, open-label, phase 3 study was conducted patients aged 35 150 days with IH 10 hospitals between 2015 2017. The comprised 6-month initial period (ITP) plus continuation if complete success not achieved, follow-up, retreatment period. Patients received twice daily...
Recent studies revealed the biological heterogeneity of medulloblastoma, with existence at least four groups which are associated several clinical and morphological features. We investigated for further correlations between molecular types, location tumours, their contrast enhancement pattern survival patients. Altogether 76 tumours were analyzed subtypes identified by immunohistochemistry using representative antibodies, detection chromosome 6 monosomy CTNNB1 mutation. The site tumour was...
Abstract Background Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) currently constitutes the leading and overwhelming health issue worldwide. In comparison with adults, children present milder symptoms, most having an asymptomatic course. We hypothesized that COVID-19 infection has a negative impact on continuation of chemotherapy increases nonrelapse mortality. Material methods This study was performed to assess course SARS-CoV-2...
Medulloblastoma (MB) is the most common malignant tumor of central nervous system in childhood. FTIR spectroscopy provides a holistic view chemical composition biological samples, including detection molecules such as nucleic acids, proteins, and lipids. This study evaluated applicability potential diagnostic tool for MB.FTIR spectra MB samples from 40 children (boys/girls: 31/9; age: median 7.8 years, range 1.5-21.5 years) treated Oncology Department Children's Memorial Health Institute...
Background/aim: The role of immune checkpoint inhibitors (ICIs; anti-PD1) in the treatment childhood cancers is still evolving. aim this nationwide retrospective study was to assess safety and effectiveness ICIs used a group 42 patients, with median age 13.6 years, various types advanced malignancies treated pediatric oncology centers Poland between 2015 2023. Results: indications for anti-PD1 were as follows: Hodgkin lymphoma (11); malignant skin melanoma (9); neuroblastoma (8); other (14)....
Abstract Purpose Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brain tumor. Radiation therapy (RT) the standard treatment, with reirradiation considered in case of progression. However, prognostic factors for are not well understood. This study aims to investigate outcomes DIPG patients undergoing and identify clinical radiomic factors. Methods We conducted retrospective analysis who underwent at our institution between January 2016 December 2023. Using PyRadiomics, we...
Ependymal tumors are the third most common group of brain in children, accounting for about 10% all primary neoplasms. According to current WHO classification, they comprise four entities with frequent ependymoma and anaplastic ependymoma. The pediatric located within posterior fossa, a tendency infiltrate vital structures. This limits surgical resection poses considerable clinical problem. Moreover, there no appropriate outcome prognostic factors besides extent resection. Despite definition...
Nijmegen breakage syndrome (NBS) is a DNA repair disorder with high predisposition to hematologic malignancies.We describe the natural history of NBS, including cancer incidence, risk death, and potential effectiveness hematopoietic stem cell transplantation (HSCT) in preventing both pathologies: malignancy immunodeficiency.Among 241 patients NBS enrolled study from 11 countries, 151 (63.0%) were diagnosed cancer. Incidence rates for primary secondary cancer, tumor characteristics, factors...
Undifferentiated embryonal sarcomas of the liver (UESL) are extremely rare and continue to pose a diagnostic therapeutic challenge. The aim study was present multicenter experience German CWS Polish PPSTG groups in treatment UESL children.Twenty-five patients were treated according CWS-96, CWS-2002, CYVADIC protocols. Distant metastases observed four cases (16%). In cases, an initial disease presentation mimicked other entities. A pure cystic appearance mass led misdiagnosis hydatid cyst...
Clostridium difficile infection (CDI) is one of the most common causes nosocomial infectious diarrhea in children during anticancer therapy or undergoing hematopoietic stem cell transplantation (HSCT) Europe. Immunosuppression these patients a risk factor for CDI. Malignant diseases, age, acute graft-versus-host disease (aGVHD), HLA mismatch, use total body irradiation may play an important role CDI course. The aim this study was to evaluate incidence, course, and outcome treated malignancy...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Krasuska-Sławińska E, Brożyna A, Dembowska-Bagińska B, Olczak-Kowalczyk D. Antineoplastic chemotherapy and congenital tooth abnormalities in children adolescents. Contemporary Oncology/Współczesna Onkologia. 2016;20(5):394-401. doi:10.5114/wo.2016.64602. APA Krasuska-Sławińska, E., Brożyna, A., Dembowska-Bagińska, B., & Olczak-Kowalczyk, (2016). Onkologia, 20(5), 394-401. https://doi.org/10.5114/wo.2016.64602...
The rapid progress made in recent years thyroid cancer research has necessitated the systematic updating of current clinical recommendations. This update presents evidence-based management differentiated carcinoma (DTC) and medullary children, including preoperative diagnostics, surgical management, radioiodine therapy DTC treatment with L-thyroxine, disease monitoring, advanced disease, finally, consequences treatment. Each recommendation is evaluated regarding its strength (Strength...