A5065869407- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Hedgehog Signaling Pathway Studies
- Ocular Oncology and Treatments
- Brain Metastases and Treatment
- Childhood Cancer Survivors' Quality of Life
- Meningioma and schwannoma management
- Soft tissue tumor case studies
- Radiation Therapy and Dosimetry
- Cancer-related Molecular Pathways
- S100 Proteins and Annexins
- Fetal and Pediatric Neurological Disorders
- ATP Synthase and ATPases Research
- Chromatin Remodeling and Cancer
- Adrenal and Paraganglionic Tumors
- Caveolin-1 and cellular processes
- Neurofibromatosis and Schwannoma Cases
- Ecology and Conservation Studies
- Anesthesia and Neurotoxicity Research
- Virus-based gene therapy research
- Cancer-related cognitive impairment studies
- Circular RNAs in diseases
- PI3K/AKT/mTOR signaling in cancer
- Radiopharmaceutical Chemistry and Applications
- MicroRNA in disease regulation
Children's Memorial Health Institute
2009-2024
Délégation Centre-Est
2012
Ependymal tumors are the third most common group of brain in children, accounting for about 10% all primary neoplasms. According to current WHO classification, they comprise four entities with frequent ependymoma and anaplastic ependymoma. The pediatric located within posterior fossa, a tendency infiltrate vital structures. This limits surgical resection poses considerable clinical problem. Moreover, there no appropriate outcome prognostic factors besides extent resection. Despite definition...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Rak B, Szlufik S, Grajkowska W, et al. Upregulation of mitogen-activated protein kinase in ganglioglioma. Folia Neuropathologica. 2013;51(4):283-289. doi:10.5114/fn.2013.39717. APA Rak, B., Szlufik, S., Grajkowska, W., Perek, D., Dembowska-Bagińska, & Filipek, I. (2013). Neuropathologica, 51(4), 283-289. https://doi.org/10.5114/fn.2013.39717 Chicago Beata, Stanisław Wiesława Danuta Bożena Iwona and Paweł...
Choroid plexus tumors (CPT) comprise choroid papilloma (CPP, WHO grade I), atypical (aCPP, II), and carcinoma (CPC, III). CPT from 20 nations were prospectively recruited into the CPT-SIOP-2000 study (01/2000–03/2010, n=129, median follow-up 7.4 years) CPT-SIOP registry (04/2010-01/2018, n=119). Non-surgical risk-stratified treatment consisted of i) chemotherapy for all CPC, metastatic incompletely resected aCPP regardless metastases ii) focal radiotherapy in non-metastatic CPC >3y, iii)...
Abstract BACKGROUND Choroid plexus carcinoma (CPC) is a rare pediatric brain tumor occuring predominantly in infancy. It commonly associated with the cancer predisposition Li-Fraumeni syndrome (LFS). Management of CPC patients LFS challenging and there no accepted standard treatment. This multinational retrospective analysis aimed to describe clinical characteristics outcome LFS-associated CPC. METHODS We identified 32 (male, n=24; median age at diagnosis 2.1 years [range, 0.3-13.2]) (CNS...
Abstract BACKGROUND Pediatric ependymomas are aggressive central nervous system malignancies arising from the ependymal linings of ventricles and spinal canal. Despite better understanding tumor biology remain therapeutic challenge in pediatric neurooncology. The role chemotherapy remains controversial. Herein, we describe outcomes patients treated at largest center Poland who underwent surgery, pre-irradiation irradiation regardless extent surgical resection. METHODS This retrospective...
Abstract INTRODUCTION Infants constitute approximately 5% of all pediatric LGG. This group is identified as having aggressive course and worse prognosis compared to older children. No specific therapeutic guidelines are yet available for this age group. AIM: Retrospective analysis infants diagnosed treated METHODOLOGY: 25 patients between 2001-2023 were analyzed for: sex, age, tumor location, pathology, treatment outcome. NF1 excluded. RESULTS There 13 boys 12 girls, aged 3 months-11 months,...
BACKGROUND: Malignant pediatric brain tumors constitute a heterogeneic group of central nervous system tumors, and general markers diagnosis prognosis are not available. Recently, panel CD (CD15, CD24, CD29) was used to define increasing neural differentiation embryonic stem cells. Although these have been associated with worse due presence tumor propagating cells, alterations in adhesion migration various cancer types, no studies multiple performed. METHODS: We collected including...
LG-49. LOW GRADE GLIOMA (LGG) OF THE SPINAL CORD. SPECIFIC LOCATION NEEDS TREATMENT Marta Perek-Polnik, Iwona Filipek, Monika Drogosiewicz, Ewa Swieszkowska, Wieslawa Grajkowska, Elzbieta Jurkiewicz, Marcin Roszkowski, and Bozenna Dembowska-Baginska; The Children’s Memorial Health Institute, Warsaw, Poland INTRODUCTION: Spinal cord LGG constitute approximately 3,5% of all locations. No specific therapeutic guidelines are available for this site. AIM: Analysis childhood spinal LGG....
Craniospinal irradiation (CSI) has been a major component of the standard care treatment backbone for childhood medulloblastoma. However, chemotherapy regimens have varied based on protocol, patient age, and molecular subtyping. In one largest studies to date, we analyzed outcomes in children with newly-diagnosed medulloblastoma treated pre-irradiation followed by risk-adapted radiotherapy maintenance chemotherapy. A total 153 patients from Polish Pediatric Neuro-Oncology Group were included...
Abstract Craniospinal irradiation (CSI) has been a major component of the standard care treatment backbone childhood medulloblastoma. However, chemotherapy regimens have varied based on protocol, patient age, and molecular subtyping. In one largest studies to date, we analyze outcomes in children with newly-diagnosed medulloblastoma treated pre-irradiation followed by risk-adapted radiotherapy maintenance chemotherapy. A total 153 patients from Polish Pediatric Neuro-oncology Group were...
Pineoblastoma is a rare, highly aggressive supratentorial tumour, more frequently diagnosed in young children. The prognosis remains poor. AIM: To present own experience with children pineoblastoma. PATIENTS AND 14 pts: 8 girls and 6 boys treated between 1998 2017 were analyzed. 5 pts (36%) under 3 years of age. 7 underwent complete tumour resection, 2-partial resection 5- biopsy. At the onset treatment six patients had disseminated disease. 9 according to protocol for MB HR group (with...
Astroblastoma is a rare CNS tumor of glial origin distinguished from other gliomas in the recent International Classification Tumors Central Nervous System proposed by World Health Organization. We present our experience with 3 astroblastoma patients. Between 2003–2017 among 978 patients tumors treated at Institution (0,3 %) were diagnosed astroblastoma. There 2 girls and 1 boy aged 2.5, 3, 5.5 years. Two had supratentorial tumors, one was located infratentorially. All underwent subtotal...
The aim of the study was to asses QoL in Medulloblastoma (MB) survivors according risk groups. MATERIAL AND Between 2005-2015 132 patients (40 girls, 92 boys aged 2 9/12 – 17 6/12) were treated MB. 44 standard and 88 high risk. Patients SR group received radiotherapy CNS 25Gy whereas HR - 36Gy. Age at analysis 6 1/12 29. Analysis included 5 year EFS/OS assessment of: weight/height percentiles groups age diagnosis, hearing loss, aids, hair loss occurrence posterior fossa syndrome(PFS)....